-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 TTV5OMYF4HlUySfewUna/QAjLuyzBGV853RNv6ewYd9O1JCFfxTcDb8xDCtCnqd2
 EKtSCq1D8N3EWebSE6uU9g==

<SEC-DOCUMENT>0001513150-11-000003.txt : 20110217
<SEC-HEADER>0001513150-11-000003.hdr.sgml : 20110217
<ACCEPTANCE-DATETIME>20110217083559
ACCESSION NUMBER:		0001513150-11-000003
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20110215
FILED AS OF DATE:		20110217
DATE AS OF CHANGE:		20110217

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Chan CHRISTIAN
		CENTRAL INDEX KEY:			0001513150

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	811-21331
		FILM NUMBER:		11619323

	MAIL ADDRESS:	
		STREET 1:		WELLS FARGO FUNDS MANAGEMENT
		STREET 2:		525 MARKET ST, 12TH FLOOR
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94105-2724

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			WELLS FARGO ADVANTAGE MULTI-SECTOR INCOME FUND
		CENTRAL INDEX KEY:			0001227073
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1031

	BUSINESS ADDRESS:	
		STREET 1:		200 BERKELEY STREET
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116
		BUSINESS PHONE:		617-210-3000

	MAIL ADDRESS:	
		STREET 1:		200 BERKELEY STREET
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	EVERGREEN MULTI-SECTOR INCOME FUND
		DATE OF NAME CHANGE:	20070530

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	EVERGREEN MANAGED INCOME FUND
		DATE OF NAME CHANGE:	20030424

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	EVERGREEN INCOME OPPORTUNITY FUND
		DATE OF NAME CHANGE:	20030415
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>primary_doc.xml
<DESCRIPTION>PRIMARY DOCUMENT
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0203</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2011-02-15</periodOfReport>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001227073</issuerCik>
        <issuerName>WELLS FARGO ADVANTAGE MULTI-SECTOR INCOME FUND</issuerName>
        <issuerTradingSymbol>ERC</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001513150</rptOwnerCik>
            <rptOwnerName>Chan CHRISTIAN</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>WELLS FARGO FUNDS MANAGEMENT</rptOwnerStreet1>
            <rptOwnerStreet2>525 MARKET ST, 12TH FLOOR</rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94105-2724</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>1</isOther>
            <otherText>Dividend Committee Member</otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <ownerSignature>
        <signatureName>Catherine F. Kennedy by power of attorney</signatureName>
        <signatureDate>2011-02-17</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----