-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 IQGTFpEhdWWWdc/M+ho05i302vmsZCENqO2yD6AvCwN0ng8LRZryiAY2nXDFfx0n
 9w/4YhCVi3XEF8TeNH9Azg==

<SEC-DOCUMENT>0001509798-11-000001.txt : 20110110
<SEC-HEADER>0001509798-11-000001.hdr.sgml : 20110110
<ACCEPTANCE-DATETIME>20110110103645
ACCESSION NUMBER:		0001509798-11-000001
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20110101
FILED AS OF DATE:		20110110
DATE AS OF CHANGE:		20110110

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Bray Michael J
		CENTRAL INDEX KEY:			0001509798

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	811-21331
		FILM NUMBER:		11519104

	MAIL ADDRESS:	
		STREET 1:		WELLS CAPITAL MANAGEMENT
		STREET 2:		100 HERITAGE RESERVE, 2ND FLOOR
		CITY:			MENOMONEE FALLS
		STATE:			WI
		ZIP:			53051-440

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			WELLS FARGO ADVANTAGE MULTI-SECTOR INCOME FUND
		CENTRAL INDEX KEY:			0001227073
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1031

	BUSINESS ADDRESS:	
		STREET 1:		200 BERKELEY STREET
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116
		BUSINESS PHONE:		617-210-3000

	MAIL ADDRESS:	
		STREET 1:		200 BERKELEY STREET
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	EVERGREEN MULTI-SECTOR INCOME FUND
		DATE OF NAME CHANGE:	20070530

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	EVERGREEN MANAGED INCOME FUND
		DATE OF NAME CHANGE:	20030424

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	EVERGREEN INCOME OPPORTUNITY FUND
		DATE OF NAME CHANGE:	20030415
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>primary_doc.xml
<DESCRIPTION>PRIMARY DOCUMENT
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0203</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2011-01-01</periodOfReport>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001227073</issuerCik>
        <issuerName>WELLS FARGO ADVANTAGE MULTI-SECTOR INCOME FUND</issuerName>
        <issuerTradingSymbol>ERC</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001509798</rptOwnerCik>
            <rptOwnerName>Bray Michael J</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>WELLS CAPITAL MANAGEMENT</rptOwnerStreet1>
            <rptOwnerStreet2>100 HERITAGE RESERVE, 2ND FLOOR</rptOwnerStreet2>
            <rptOwnerCity>MENOMONEE FALLS</rptOwnerCity>
            <rptOwnerState>WI</rptOwnerState>
            <rptOwnerZipCode>53051-440</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>1</isOther>
            <otherText>Portfolio Manager</otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <ownerSignature>
        <signatureName>Catherine F. Kennedy by power of attorney</signatureName>
        <signatureDate>2011-01-10</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----