-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 Ifi92yxYC6GZ/JdoOypfc5L0kec8ZlfgBTmCqNaV1bWmwyU3fstuqjb7yJcO+qr3
 hB84anNeFQWQQkRlJhMWgA==

<SEC-DOCUMENT>0001230748-10-000003.txt : 20101209
<SEC-HEADER>0001230748-10-000003.hdr.sgml : 20101209
<ACCEPTANCE-DATETIME>20101209112019
ACCESSION NUMBER:		0001230748-10-000003
CONFORMED SUBMISSION TYPE:	5
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20101031
FILED AS OF DATE:		20101209
DATE AS OF CHANGE:		20101209

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			PETTIT WILLIAM W
		CENTRAL INDEX KEY:			0001230748

	FILING VALUES:
		FORM TYPE:		5
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	811-21331
		FILM NUMBER:		101241500

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			WELLS FARGO ADVANTAGE MULTI-SECTOR INCOME FUND
		CENTRAL INDEX KEY:			0001227073
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1031

	BUSINESS ADDRESS:	
		STREET 1:		200 BERKELEY STREET
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116
		BUSINESS PHONE:		617-210-3000

	MAIL ADDRESS:	
		STREET 1:		200 BERKELEY STREET
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	EVERGREEN MULTI-SECTOR INCOME FUND
		DATE OF NAME CHANGE:	20070530

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	EVERGREEN MANAGED INCOME FUND
		DATE OF NAME CHANGE:	20030424

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	EVERGREEN INCOME OPPORTUNITY FUND
		DATE OF NAME CHANGE:	20030415
</SEC-HEADER>
<DOCUMENT>
<TYPE>5
<SEQUENCE>1
<FILENAME>primary_doc.xml
<DESCRIPTION>PRIMARY DOCUMENT
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0303</schemaVersion>

    <documentType>5</documentType>

    <periodOfReport>2010-10-31</periodOfReport>

    <notSubjectToSection16>1</notSubjectToSection16>

    <form3HoldingsReported>0</form3HoldingsReported>

    <form4TransactionsReported>0</form4TransactionsReported>

    <issuer>
        <issuerCik>0001227073</issuerCik>
        <issuerName>WELLS FARGO ADVANTAGE MULTI-SECTOR INCOME FUND</issuerName>
        <issuerTradingSymbol>ERC</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001230748</rptOwnerCik>
            <rptOwnerName>PETTIT WILLIAM W</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1></rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity></rptOwnerCity>
            <rptOwnerState></rptOwnerState>
            <rptOwnerZipCode></rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>1</isOther>
            <otherText>Former Director</otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <ownerSignature>
        <signatureName>William W Pettit</signatureName>
        <signatureDate>2010-12-09</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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