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Weighted-Average Assumptions for Stock Option (Detail)
3 Months Ended 9 Months Ended
Sep. 30, 2013
Sep. 30, 2012
Sep. 30, 2013
Sep. 30, 2012
Stock Options
       
Weighted-average assumptions for stock options and ESPP        
Risk-free interest rate 0.70% 0.62% 0.80% 0.62%
Expected volatility of common stock 85.76% 82.22% 86.10% 82.14%
Dividend yield 0.00% 0.00% 0.00% 0.00%
Expected term (in years) 5 years 4 months 24 days 5 years 3 months 18 days 5 years 6 months 5 years 3 months 18 days
ESPP
       
Weighted-average assumptions for stock options and ESPP        
Risk-free interest rate 0.15% 0.16% 0.18% 0.34%
Expected volatility of common stock 91.60% 74.34% 91.55% 75.52%
Dividend yield 0.00% 0.00% 0.00% 0.00%
Expected term (in years) 6 months 6 months 6 months 6 months