The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ANI PHARMACEUTICALS INC COM 00182C103 1,411 45,000 SH   SOLE   45,000 0 0
ABBVIE INC COM 00287Y109 3,444 67,000 SH   SOLE   67,000 0 0
ABIOMED INC COM 003654100 130 5,000 SH   SOLE   5,000 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 16,204 666,000 SH   SOLE   666,000 0 0
ACASTI PHARMA INC CL A SHRS 00430K105 3,299 2,869,447 SH   SOLE   2,869,447 0 0
ACHAOGEN INC COM 004449104 928 60,000 SH   SOLE   60,000 0 0
ACELRX PHARMACEUTICALS INC COM 00444T100 78,954 6,574,060 SH   SOLE   6,574,060 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 4,482 211,518 SH   SOLE   211,518 0 0
AGENUS INC COM NEW 00847G705 634 200,000 SH   SOLE   200,000 0 0
ALERE INC COM 01449J105 127 3,700 SH   SOLE   3,700 0 0
ALLIQUA COM 019621200 6,472 784,594 SH   SOLE   784,594 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 3,357 50,000 SH   SOLE   50,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 2,000 966,300 SH   SOLE   966,300 0 0
ANACOR PHARMACEUTICALS INC COM 032420101 12,947 647,015 SH   SOLE   647,015 0 0
ANTHERA PHARMACEUTICALS INC COM NEW 03674U201 1,603 478,456 SH   SOLE   478,456 0 0
AQUINOX PHARMACEUTICALS INC COM 03842B101 1,655 130,000 SH   SOLE   130,000 0 0
ARNO THERAPEUTICS COM 042564203 4,517 2,034,721 SH   SOLE   2,034,721 0 0
ARROWHEAD RESH CORP COM NEW 042797209 5,210 317,300 SH   SOLE   317,300 0 0
ATHERSYS INC COM 04744L106 2,273 701,582 SH   SOLE   701,582 0 0
ATRICURE INC COM 04963C209 1,881 100,000 SH   SOLE   100,000 0 0
BIODELIVERY SCIENCES INTL IN COM 09060J106 1,604 190,000 SH   SOLE   190,000 0 0
BIOTA PHARMACEUTIALS INC COM 090694100 2,536 415,000 SH   SOLE   415,000 0 0
BIOLINERX LTD SPONSORED ADR 09071M106 399 179,041 SH   SOLE   179,041 0 0
BLUEBIRD BIO INC COM 09609G100 455 20,000 SH   SOLE   20,000 0 0
CIGNA CORPORATION COM 125509109 106 1,269 SH   SOLE   1,269 0 0
CAPITAL SR LIVING CORP COM 140475104 5,263 202,500 SH   SOLE   202,500 0 0
CASTLIGHT HEALTH INC COM 14862Q100 180 8,500 SH   SOLE   8,500 0 0
CELGENE CORP COM 151020104 28,786 206,200 SH   SOLE   206,200 0 0
CENTENE CORP DEL COM 15135B101 162 2,610 SH   SOLE   2,610 0 0
CHAMPIONS ONCOLOGY COM 15870P109 1,609 1,625,299 SH   SOLE   1,625,299 0 0
CHELSEA THERAPEUTICS INTL LT COM 163428105 7,185 1,301,639 SH   SOLE   1,301,639 0 0
CHIMERIX INC COM 16934W106 3,199 140,000 SH   SOLE   140,000 0 0
CLOVIS ONCOLOGY INC COM 189464100 11,929 172,217 SH   SOLE   172,217 0 0
COMBIMATRIX CORPORATION W EXP 5-1-2014 20009T121 9 5,000 SH   SOLE   5,000 0 0
CYTOKINETICS INC COM NEW 23282W605 6,650 700,000 SH Call SOLE   700,000 0 0
DAVITA HEALTHCARE PARTNERS I COM 23918K108 164 2,382 SH   SOLE   2,382 0 0
DERMA SCIENCES INC COM PAR .01 249827502 6,756 532,800 SH   SOLE   532,800 0 0
DURECT CORP COM 266605104 1,206 907,064 SH   SOLE   907,064 0 0
DYAX CORP COM 26746E103 23,013 2,562,674 SH   SOLE   2,562,674 0 0
ENDOCYTE INC COM 29269A102 10,357 435,000 SH   SOLE   435,000 0 0
ENZO BIOCHEM INC COM 294100102 1,581 380,000 SH   SOLE   380,000 0 0
EPIZYME INC COM 29428V104 1,198 52,602 SH   SOLE   52,602 0 0
EXACT SCIENCES CORP COM 30063P105 25,862 1,825,150 SH   SOLE   1,825,150 0 0
EXACT SCIENCES CORP COM 30063P105 12,753 900,000 SH Put SOLE   900,000 0 0
EXELIXIS INC COM 30161Q104 1,416 400,000 SH Call SOLE   400,000 0 0
FIVE PRIME THERAPEUTICS INC COM 33830X104 2,949 150,000 SH   SOLE   150,000 0 0
FLAMEL TECHNOLOGIES SA SPONSORED ADR 338488109 10,720 800,000 SH   SOLE   800,000 0 0
FLUIDIGM CORP DEL COM 34385P108 135 3,070 SH   SOLE   3,070 0 0
GENVEC INC COM NEW 37246C307 2,173 820,000 SH   SOLE   820,000 0 0
GILEAD SCIENCES INC COM 375558103 3,543 50,000 SH   SOLE   50,000 0 0
GLOBUS MED INC CL A SHRS 379577208 4,520 170,000 SH   SOLE   170,000 0 0
HCA HOLDINGS INC COM 40412C101 7,875 150,000 SH   SOLE   150,000 0 0
HEALTH NET INC COM 42222G108 179 5,275 SH   SOLE   5,275 0 0
HERON THERAPEUTICS INC COM 427746102 24,515 1,762,426 SH   SOLE   1,762,426 0 0
HORIZON PHARMA INC COM 44047T109 138 9,120 SH   SOLE   9,120 0 0
HUMANA INC COM 444859102 141 1,250 SH   SOLE   1,250 0 0
ICAD INC COM NEW 44934S206 1,603 175,000 SH   SOLE   175,000 0 0
IDENIX PHARMACEUTICALS INC COM 45166R204 1,809 300,000 SH Call SOLE   300,000 0 0
ILLUMINA INC COM 452327109 372 2,500 SH   SOLE   2,500 0 0
IMPAX LABORATORIES INC COM 45256B101 158 5,962 SH   SOLE   5,962 0 0
INCYTE CORP COM 45337C102 9,837 183,800 SH   SOLE   183,800 0 0
INSMED INC COM PAR .01 457669307 6,474 340,000 SH   SOLE   340,000 0 0
INSYS THERAPEUTICS INC NEW COM NEW 45824V209 255 6,153 SH   SOLE   6,153 0 0
INTERMUNE INC COM 45884X103 3,347 100,000 SH Call SOLE   100,000 0 0
INTERMUNE INC COM 45884X103 8,702 260,000 SH   SOLE   260,000 0 0
KERYX BIOPHARMACEUTICALS INC COM 492515101 4,686 275,000 SH   SOLE   275,000 0 0
LANNET INC COM 516012101 241 6,744 SH   SOLE   6,744 0 0
LION BIOTECHNOLOGIES COM 53619R102 28,320 3,000,000 SH   SOLE   3,000,000 0 0
MGC DIAGNOSTICS CORP COM 552768103 2,310 206,957 SH   SOLE   206,957 0 0
MACROGENICS INC COM 556099109 12,494 448,945 SH   SOLE   448,945 0 0
MEDGENICS INC COM NEW 58436Q203 428 61,263 SH   SOLE   61,263 0 0
MEDIDATA SOLUTIONS INC COM 58471A105 152 2,802 SH   SOLE   2,802 0 0
MEDIVATION INC COM 58501N101 2,053 31,900 SH   SOLE   31,900 0 0
MYLAN INC COM 628530107 11,353 232,500 SH   SOLE   232,500 0 0
NEPTUNE TECHNOLOGIES BIORESO COM 64077P108 16,550 6,700,444 SH   SOLE   6,700,444 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 74,372 4,619,367 SH   SOLE   4,619,367 0 0
NEWLINK GENETICS CORP COM 651511107 1,420 50,000 SH Call SOLE   50,000 0 0
OMNICARE INC COM 681904108 103 1,732 SH   SOLE   1,732 0 0
ONCOTHYREON INC COM 682324108 1,624 543,000 SH   SOLE   543,000 0 0
OPHTHOTECH CORP COM 683745103 8,935 250,000 SH   SOLE   250,000 0 0
OXIGENE INC COM PAR .001 691828404 1,865 500,000 SH   SOLE   500,000 0 0
PTC THERAPEUTICS COM 69366J200 17,558 671,736 SH   SOLE   671,736 0 0
PACIRA PHARMACEUTICALS COM 695127100 139 2,000 SH   SOLE   2,000 0 0
PAIN THERAPEUTICS COM 69562K100 194 35,506 SH   SOLE   35,506 0 0
PUMA BIOTECHNOLOGY COM 74587V107 76 735 SH   SOLE   735 0 0
QUESTCOR PHARMACEUTICALS COM 74835Y101 1,857 28,600 SH   SOLE   28,600 0 0
RECEPTOS INC COM 756207106 1,468 35,000 SH   SOLE   35,000 0 0
RELYPSA INC COM 759531106 5,402 181,200 SH   SOLE   181,200 0 0
REPLIGEN CORP COM 759916109 579 45,000 SH Put SOLE   45,000 0 0
RETROPHIN INC COM 761299106 22,138 1,044,292 SH   SOLE   1,044,292 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 194 50,000 SH   SOLE   50,000 0 0
RITE AID CORP COM 767754104 94 14,924 SH   SOLE   14,924 0 0
SANGAMO BIOSCIENCES INC COM 800677106 14,464 800,000 SH   SOLE   800,000 0 0
Sarepta Therapeutics Inc COM 803607100 8,413 350,000 SH Call SOLE   350,000 0 0
SAREPTA THERAPEUTICS INC COM 803607100 69,182 2,878,979 SH   SOLE   2,878,979 0 0
SHIRE PLC SPONSORED ADR 82481R106 4,456 30,000 SH   SOLE   30,000 0 0
SPECTRANETICS CORP COM 84760C107 10,080 332,554 SH   SOLE   332,554 0 0
STEMCELLS INC COM NEW 85857R204 364 271,600 SH   SOLE   271,600 0 0
STEMLINE THERAPEUTICS INC COM 85858C107 1 38 SH   SOLE   38 0 0
SURGICAL CARE AFFILIATES INC COM 86881L106 230 7,472 SH   SOLE   7,472 0 0
TANDEM DIABETES CARE INC COM 875372104 2,339 105,900 SH   SOLE   105,900 0 0
TEKMIRA PHARMACEUTICALS CORP COM NEW 87911B209 2,149 100,000 SH Put SOLE   100,000 0 0
TESARO INC COM 881569107 36,262 1,230,070 SH   SOLE   1,230,070 0 0
THERAPEUTICSMD INC COM 88338N107 44 7,000 SH   SOLE   7,000 0 0
TRANSGENOMIC INC COM 89365K305 842 183,957 SH   SOLE   183,957 0 0
TREVENA INC COM 89532E109 6,052 770,000 SH   SOLE   770,000 0 0
UROPLASTY INC COM NEW 917277204 1,880 517,791 SH   SOLE   517,791 0 0
VERASTEM INC COM 92337C104 2,391 220,000 SH   SOLE   220,000 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 21,216 300,000 SH Put SOLE   300,000 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 41,140 581,728 SH   SOLE   581,728 0 0
VIVUS INC COM 928551100 594 100,000 SH Put SOLE   100,000 0 0
VOCERA COMMUNICATIONS INC COM 92857F107 163 10,000 SH   SOLE   10,000 0 0
WALGREEN CO COM 931422109 20,101 304,419 SH   SOLE   304,419 0 0
WRIGHT MED GROUP INC COM 98235T107 311 10,000 SH   SOLE   10,000 0 0
XENCOR INC COM 98401F105 17,462 1,488,672 SH   SOLE   1,488,672 0 0
XENOPORT INC COM 98411C100 258 50,000 SH   SOLE   50,000 0 0
ZELTIQ AESTHETICS INC COM 98933Q108 11,503 586,013 SH   SOLE   586,013 0 0
ACTAVIS PLC SHS G0083B108 195 945 SH   SOLE   945 0 0
COVIDIEN PLC SHS G2554F113 19,365 262,900 SH   SOLE   262,900 0 0
ENDO INTL PLC SHS G30401106 78 1,138 SH   SOLE   1,138 0 0
PROTHENA CORP PLC SHS G72800108 13,409 350,000 SH   SOLE   350,000 0 0
COMPUGEN LTD ORD M25722105 1,787 170,000 SH   SOLE   170,000 0 0
ENZYMOTEC LTD SHS M4059L101 4,717 214,219 SH   SOLE   214,219 0 0
GALMED PHARMACEUTICALS LTD SHS M47238106 860 75,000 SH   SOLE   75,000 0 0
SYNERON MEDICAL LTD ORD M87245102 1,587 127,500 SH   SOLE   127,500 0 0
TARO PHARMACEUTICAL INDS LTD SHS M8737E108 10,768 97,011 SH   SOLE   97,011 0 0
VERSARTIS INC COM 92529L102 15,063 501,266 SH   SOLE   501,266 0 0