The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACASTI PHARMA INC CL A SHS 00430K105 5,236 4,389,685 SH   SOLE   4,389,685 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 5,388 300,000 SH   SOLE   300,000 0 0
AXOGEN INC COM 05463X106 20 4,500 SH   SOLE   4,500 0 0
BLUEBIRD BIO INC COM 09609G100 420 20,000 SH   SOLE   20,000 0 0
CHIMERIX INC COM 16934W106 2,262 150,000 SH   SOLE   150,000 0 0
FIVE PRIME THERAPEUTICS INC COM 33830X104 2,225 132,500 SH   SOLE   132,500 0 0
GENTIUM S P A SPONSORED ADR 37250B104 6,852 120,000 SH   SOLE   120,000 0 0
MACROGENICS INC COM 556099109 19,687 717,705 SH   SOLE   717,705 0 0
MGC DIAGNOSTICS CORP COM 552768103 2,274 179,619 SH   SOLE   179,619 0 0
OREXIGEN THERAPEUTICS INC NOTE 2.750%12/0 686164AA2 732 750,000 PRN   SOLE   750,000 0 0
RELYPSA INC COM 759531106 8,530 341,200 SH   SOLE   341,200 0 0
STEMCELLS INC COM NEW 85857R204 334 271,600 SH   SOLE   271,600 0 0
STEMLINE THERAPEUTICS INC COM 85858C107 1 38 SH   SOLE   38 0 0
SURGICAL CARE AFFILIATES INC COM 86881L106 697 20,000 SH   SOLE   20,000 0 0
TANDEM DIABETES CARE INC COM 875372104 2,995 116,235 SH   SOLE   116,235 0 0
VERASTEM INC COM 92337C104 2,517 220,000 SH   SOLE   220,000 0 0
XENCOR INC COM 98401F105 14,338 1,568,672 SH   SOLE   1,568,672 0 0
ABBVIE INC COM 00287Y109 18,484 350,000 SH   SOLE   350,000 0 0
ACELRX PHARMACEUTICALS INC COM 00444T100 74,353 6,574,060 SH   SOLE   6,574,060 0 0
AEGERION PHARMACEUTICALS INC COM 00767E102 31,775 447,785 SH   SOLE   447,785 0 0
AFFYMETRIX INC COM 00826T108 73 8,538 SH   SOLE   8,538 0 0
ALERE INC COM 01449J105 149 4,127 SH   SOLE   4,127 0 0
ALLIQUA COM 019621200 4,041 557,491 SH   SOLE   557,491 0 0
ANACOR PHARMACEUTICALS INC COM 32420101 7,959 474,303 SH   SOLE   474,303 0 0
ANACOR PHARMACEUTICALS INC COM 32420101 222 13,239 SH   SOLE   13,239 0 0
ANALOGIC CORP COM PAR $0.05 32657207 146 1,644 SH   SOLE   1,644 0 0
ANTHERA PHARMACEUTICALS INC COM NEW 03674U201 1,325 431,456 SH   SOLE   431,456 0 0
ARNO THERAPEUTICS COM 042564203 5,697 2,034,721 SH   SOLE   2,034,721 0 0
ASTRAZENECA PLC SPONSORED ADR 46353108 152 2,558 SH   SOLE   2,558 0 0
ATHENAHEALTH INC COM 04685W103 336 2,500 SH Call SOLE   2,500 0 0
ATHERSYS INC COM 04744L106 4,252 1,700,887 SH   SOLE   1,700,887 0 0
AUXILIUM PHARMACEUTICALS INC COM 05334D107 2,074 100,000 SH   SOLE   100,000 0 0
BIOCRYST PHARMACEUTICALS COM 09058V103 1,501 197,500 SH   SOLE   197,500 0 0
BIOGEN IDEC INC COM 09062X103 11,190 40,000 SH   SOLE   40,000 0 0
CAPITAL SR LIVING CORP COM 140475104 5,008 208,753 SH   SOLE   208,753 0 0
CELGENE CORP COM 151020104 86,034 509,200 SH   SOLE   509,200 0 0
CELL THERAPEUTICS INC COM NPV NEW 2012 150934883 7,133 3,715,000 SH   SOLE   3,715,000 0 0
CENTENE CORP DEL COM 15135B101 154 2,610 SH   SOLE   2,610 0 0
CHAMPION ONCOLOGY COM 15870P109 1,950 1,625,744 SH   SOLE   1,625,744 0 0
CHELSEA THERAPEUTICS INTL LT COM 163428105 7,538 1,701,639 SH   SOLE   1,701,639 0 0
CIGNA CORPORATION COM 125509109 10,935 125,000 SH   SOLE   125,000 0 0
CLOVIS ONCOLOGY INC COM 189464100 1,843 30,585 SH   SOLE   30,585 0 0
COMBIMATRIX CORPORATION *W EXP 05/01/201 20009T121 3 5,000 SH   SOLE   5,000 0 0
COVIDIEN PLC SHS G2554F113 11,640 170,926 SH   SOLE   170,926 0 0
COVIDIEN PLC SHS G2554F113 375 5,500 SH   SOLE   5,500 0 0
COVIDIEN PLC SHS G2554F113 13,511 198,400 SH   SOLE   198,400 0 0
CURIS INC COM 231269101 987 350,000 SH   SOLE   350,000 0 0
CUTERA INC COM 232109108 228 22,400 SH   SOLE   22,400 0 0
CVS CAREMARK CORPORATION COM 126650100 6,241 87,200 SH   SOLE   87,200 0 0
CVS CAREMARK CORPORATION COM 126650100 152 2,130 SH   SOLE   2,130 0 0
DAVITA HEALTHCARE PARTNERS I COM 23918K108 151 2,382 SH   SOLE   2,382 0 0
DEXCOM INC COM 252131107 1,062 30,000 SH   SOLE   30,000 0 0
DYAX CORP COM 26746E103 17,565 2,332,674 SH   SOLE   2,332,674 0 0
ENDO HEALTH SOLUTIONS INC COM 29264F205 77 1,138 SH   SOLE   1,138 0 0
ENDOCYTE INC COM 29269A102 4,504 421,300 SH   SOLE   421,300 0 0
ENDOCYTE INC COM 29269A102 2,138 200,000 SH Put SOLE   200,000 0 0
ENDOCYTE INC COM 29269A102 2,138 200,000 SH Call SOLE   200,000 0 0
ENZO BIOCHEM INC COM 29269A102 730 250,000 SH   SOLE   250,000 0 0
EXACT SCIENCES CORP COM 30063P105 22,480 1,923,003 SH   SOLE   1,923,003 0 0
EXACT SCIENCES CORP COM 30063P105 551 46,900 SH   SOLE   46,900 0 0
EXPRESS SCRIPTS HLDG CO COM 30219G108 146 2,080 SH   SOLE   2,080 0 0
FLUIDIGM CORP DEL COM 34385P108 78 2,030 SH   SOLE   2,030 0 0
GERON CORP COM 374163103 22 4,684 SH   SOLE   4,684 0 0
GILEAD SCIENCES INC COM 375558103 3,758 50,000 SH   SOLE   50,000 0 0
HEALTH NET INC COM 42222G108 7,937 267,500 SH   SOLE   267,500 0 0
HEALTH NET INC COM 42222G108 157 5,275 SH   SOLE   5,275 0 0
HEARTWARE INTL INC COM 422368100 7,977 84,900 SH   SOLE   84,900 0 0
HILL ROM HLDGS INC COM 431475102 152 3,687 SH   SOLE   3,687 0 0
HOLOGIC INC COM 436440101 559 25,000 SH Call SOLE   25,000 0 0
IDENIX PHARMACEUTICALS INC COM 45166R204 1,794 300,000 SH Call SOLE   300,000 0 0
ILLUMINA INC COM 452327109 221 2,000 SH   SOLE   2,000 0 0
IMMUNOMEDICS INC COM 452907108 13 2,853 SH   SOLE   2,853 0 0
IMPAX LABORATORIES INC COM 45256B101 150 5,962 SH   SOLE   5,962 0 0
INCYTE CORP COM 45337C102 13,609 268,800 SH   SOLE   268,800 0 0
INFINITY PHARMACEUTICALS INC COM 45665G303 4,834 350,000 SH   SOLE   350,000 0 0
INSYS THERAPEUTICS INC NEW COM NEW 45824V209 221 5,722 SH   SOLE   5,722 0 0
LANNET INC COM 516012101 223 6,744 SH   SOLE   6,744 0 0
MANNKIND CORP COM 56400P201 19,772 3,795,000 SH   SOLE   3,795,000 0 0
MEDGENICS INC COM NEW 58436Q203 367 61,263 SH   SOLE   61,263 0 0
MEDIDATA SOLUTIONS INC COM 58471A105 220 3,642 SH   SOLE   3,642 0 0
MIMEDX GROUP INC COM 602496101 874 100,000 SH   SOLE   100,000 0 0
MYLAN INC COM 628530107 17,035 392,500 SH   SOLE   392,500 0 0
MYRIAD GENETICS INC COM 62855J104 210 10,000 SH Put SOLE   10,000 0 0
NANOSPHERE INC COM 63009F105 676 295,000 SH   SOLE   295,000 0 0
NAVIDEA BIOPHARMACEUTICALS I COM 63937X103 207 100,000 SH Put SOLE   100,000 0 0
NEOSTEM INC COM PAR $.001 640650404 1,566 229,593 SH   SOLE   229,593 0 0
NEPTUNE TECHNOLOGIES BIORESO COM 64077P108 17,111 5,900,444 SH   SOLE   5,900,444 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 39,076 4,183,737 SH   SOLE   4,183,737 0 0
NEWCASTLE INVT CORP COM 65105M108 402 70,000 SH   SOLE   70,000 0 0
OMNICARE INC COM 681904108 150 2,492 SH   SOLE   2,492 0 0
ONCOTHYREON INC COM 682324108 880 500,000 SH   SOLE   500,000 0 0
OPHTHOTECH CORP COM 683745103 2,426 75,000 SH   SOLE   75,000 0 0
PAIN THERAPEUTICS INC COM 69562K100 172 35,506 SH   SOLE   35,506 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 76 735 SH   SOLE   735 0 0
REPLIGEN CORP COM 759916109 2,251 165,000 SH Put SOLE   165,000 0 0
REPROS THERAPEUTICS INC COM NEW 76028H209 1,315 71,879 SH   SOLE   71,879 0 0
RETROPHIN INC COM 761299106 7,368 1,052,692 SH   SOLE   1,052,692 0 0
RITE AID CORP COM 767754104 76 14,924 SH   SOLE   14,924 0 0
SANTARUS INC COM 802817304 1,451 45,400 SH   SOLE   45,400 0 0
SAREPTA THERAPEUTICS INC COM 803607100 70,981 3,484,579 SH   SOLE   3,484,579 0 0
Sarepta Therapeutics Inc COM 803607100 13,241 650,000 SH Put SOLE   650,000 0 0
SHIRE PLC SPONSORED ADR 82481R106 1,413 10,000 SH   SOLE   10,000 0 0
SPECTRANETICS CORP COM 84760C107 8,656 346,254 SH   SOLE   346,254 0 0
TANDEM DIABETES CARE INC COM 875372104 241 9,365 SH   SOLE   9,365 0 0
TARO PHARMACEUTICAL INDS LTD SHS M8737E108 5,598 56,602 SH   SOLE   56,602 0 0
TESARO INC COM 881569107 40,851 1,446,570 SH   SOLE   1,446,570 0 0
TORNIER N V SHS N87237108 188 10,000 SH   SOLE   10,000 0 0
TRANSGENOMIC INC COM 89365k206 1,004 2,207,500 SH   SOLE   2,207,500 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 792 7,000 SH   SOLE   7,000 0 0
UROPLASTY INC COM NEW 917277204 857 313,989 SH   SOLE   313,989 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 60,311 811,728 SH   SOLE   811,728 0 0
VIVUS INC COM 928551100 908 100,000 SH Put SOLE   100,000 0 0
WALGREEN CO COM 931422109 18,496 322,000 SH   SOLE   322,000 0 0
XENOPORT INC COM 98411C100 288 50,000 SH   SOLE   50,000 0 0
ZELTIQ AESTHETICS INC COM 98933Q108 5,548 293,400 SH   SOLE   293,400 0 0
ZELTIQ AESTHETICS INC COM 98933Q108 231 12,193 SH   SOLE   12,193 0 0
ZIMMER HLDGS INC COM 98956P102 1,864 20,000 SH   SOLE   20,000 0 0
ZOGENIX INC COM 98978L105 2,236 650,000 SH   SOLE   650,000 0 0