The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
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COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y109   19,393,650 106,500 SH   SOLE   106,500 0 0
ABSCI CORPORATION COM 00091E109   3,976,000 700,000 SH   SOLE   700,000 0 0
ACRIVON THERAPEUTICS INC COMMON STOCK 004890109   21,506,185 3,007,858 SH   SOLE   3,007,858 0 0
ADMA BIOLOGICS INC COM 000899104   42,460,235 6,433,369 SH   SOLE   6,433,369 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104   2,924,000 100,000 SH Call SOLE   100,000 0 0
AKERO THERAPEUTICS INC COM 00973Y108   35,047,517 1,387,471 SH   SOLE   1,387,471 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106   28,101,026 8,593,586 SH   SOLE   8,593,586 0 0
AMICUS THERAPEUTICS INC COM 03152W109   330,516,832 28,057,456 SH   SOLE   28,057,456 0 0
AMYLYX PHARMACEUTICALS INC COM 03237H101   4,768,715 1,679,125 SH Call SOLE   1,679,125 0 0
AMYLYX PHARMACEUTICALS INC COM 03237H101   852,000 300,000 SH   SOLE   300,000 0 0
APOGEE THERAPEUTICS INC COM 03770N101   179,371,475 2,699,345 SH   SOLE   2,699,345 0 0
APPLIED THERAPEUTICS INC COM 03828A101   54,434,000 8,005,000 SH   SOLE   8,005,000 0 0
APPLIED THERAPEUTICS INC COM 03828A101   3,400,000 500,000 SH Call SOLE   500,000 0 0
ARCELLX INC COMMON STOCK 03940C100   273,578,820 3,933,556 SH   SOLE   3,933,556 0 0
ARCUTIS BIOTHERAPEUTICS INC COM 03969K108   7,432,500 750,000 SH   SOLE   750,000 0 0
ARRIVENT BIOPHARMA INC COM 04272N102   7,411,900 415,000 SH   SOLE   415,000 0 0
ARS PHARMACEUTICALS INC COM 82835W108   8,864,000 867,319 SH   SOLE   867,319 0 0
ARTIVION INC COM 228903100   56,475,574 2,668,978 SH   SOLE   2,668,978 0 0
ARVINAS INC COM 04335A105   51,046,972 1,236,603 SH   SOLE   1,236,603 0 0
ASTRIA THERAPEUTICS INC COM 04635X102   91,249,859 6,485,420 SH   SOLE   6,485,420 0 0
ATHIRA PHARMA INC COM 04746L104   14,804,121 5,402,964 SH   SOLE   5,402,964 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100   27,630,153 4,330,745 SH   SOLE   4,330,745 0 0
AXOGEN INC COM 05463X106   12,540,207 1,553,929 SH   SOLE   1,553,929 0 0
AXSOME THERAPEUTICS INC COM 05464T104   88,206,212 1,105,341 SH   SOLE   1,105,341 0 0
BIOHAVEN LTD COM G1110E107   94,342,820 1,725,047 SH   SOLE   1,725,047 0 0
BRIDGEBIO PHARMA INC COM 10806X102   43,660,060 1,412,033 SH   SOLE   1,412,033 0 0
CABALETTA BIO INC COM 12674W109   29,286,220 1,716,660 SH   SOLE   1,716,660 0 0
CAREMAX INC CL A NEW 14171W202   591,139 122,643 SH   SOLE   122,643 0 0
CAREMAX INC *W EXP 06/08/202 14171W111   1,026 60,000 SH   SOLE   60,000 0 0
CARGO THERAPEUTICS INC COM 14179K101   76,959,449 3,448,004 SH   SOLE   3,448,004 0 0
CELCUITY INC COM 15102K100   51,025,226 2,362,279 SH   SOLE   2,362,279 0 0
CENTESSA PHARMACEUTICALS PLC SPONSORED ADS 152309100   34,841,369 3,083,307 SH   SOLE   3,083,307 0 0
CEREVEL THERAPEUTICS HLDNG I COM 15678U128   456,299,409 10,794,876 SH   SOLE   10,794,876 0 0
CG ONCOLOGY INC COM 156944100   57,250,210 1,304,105 SH   SOLE   1,304,105 0 0
COGENT BIOSCIENCES INC COM 19240Q201   5,935,998 883,333 SH   SOLE   883,333 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107   69,101,062 1,476,203 SH   SOLE   1,476,203 0 0
DISC MEDICINE INC COM 254604101   58,516,057 939,866 SH   SOLE   939,866 0 0
DISC MEDICINE INC COM 254604101   18,678,000 300,000 SH Put SOLE   300,000 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105   42,310,343 2,319,646 SH   SOLE   2,319,646 0 0
ENGENE HOLDINGS INC COM 29286M105   16,931,152 998,888 SH   SOLE   998,888 0 0
ENVVENO MEDICAL CORPORATION COM 29415J106   3,390,834 623,315 SH   SOLE   623,315 0 0
ESTABLISHMENT LABS HLDGS INC COM G31249108   4,189,019 82,299 SH   SOLE   82,299 0 0
EVOLUS INC COM 30052C107   80,553,172 5,753,798 SH   SOLE   5,753,798 0 0
EYEPOINT PHARMACEUTICALS INC COM NEW 30233G209   12,187,983 589,646 SH   SOLE   589,646 0 0
FORTE BIOSCIENCES INC COM 34962G109   2,273,343 3,265,359 SH   SOLE   3,265,359 0 0
FUSION PHARMACEUTICALS INC COM 36118A100   145,517,421 6,825,395 SH   SOLE   6,825,395 0 0
HELIX ACQUISITION CORP II CL A ORD SHS G4444H101   5,200,000 500,000 SH   SOLE   500,000 0 0
IMMATICS N.V SHS N44445109   48,161,118 4,582,409 SH   SOLE   4,582,409 0 0
IMMUNITYBIO INC COM 45256X103   5,654,003 1,052,887 SH   SOLE   1,052,887 0 0
IMMUNOVANT INC COM 45258J102   95,741,380 2,963,212 SH   SOLE   2,963,212 0 0
IMMUNOVANT INC COM 45258J102   3,231,000 100,000 SH Call SOLE   100,000 0 0
INHIBRX INC COM 45720L107   148,793,396 4,256,104 SH   SOLE   4,256,104 0 0
INTRA-CELLULAR THERAPIES INC COM 46116X101   73,030,566 1,055,355 SH   SOLE   1,055,355 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602   40,627,362 101,800 SH   SOLE   101,800 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100   285,625,572 19,272,991 SH   SOLE   19,272,991 0 0
IRHYTHM TECHNOLOGIES INC COM 450056106   28,443,780 245,205 SH   SOLE   245,205 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103   5,930,000 500,000 SH   SOLE   500,000 0 0
KURA ONCOLOGY INC COM 50127T109   1,028,106 48,200 SH   SOLE   48,200 0 0
KYVERNA THERAPEUTICS INC COM 501976104   3,726,000 150,000 SH   SOLE   150,000 0 0
LANDOS BIOPHARMA INC COM NEW 515069201   31,940,566 1,486,991 SH   SOLE   1,486,991 0 0
LIVANOVA PLC SHS G5509L101   16,726,060 299,000 SH   SOLE   299,000 0 0
LYRA THERAPEUTICS INC COM 55234L105   79,352,035 12,757,562 SH   SOLE   12,757,562 0 0
MACROGENICS INC COM 556099109   5,568,973 378,327 SH   SOLE   378,327 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105   114,814,649 429,953 SH   SOLE   429,953 0 0
MEDTRONIC PLC SHS G5960L103   124,586,415 1,429,563 SH   SOLE   1,429,563 0 0
MEIRAGTX HLDGS PLC COM G59665102   68,723,711 11,331,103 SH   SOLE   11,331,103 0 0
MOONLAKE IMMUNOTHERAPEUTICS CLASS A ORD 61559X104   17,028,573 339,012 SH   SOLE   339,012 0 0
MORPHIC HLDG INC COM 61775R105   10,145,379 288,221 SH   SOLE   288,221 0 0
NANOBIOTIX SPONSORED ADS 63009J107   3,607,873 555,066 SH   SOLE   555,066 0 0
NATERA INC COM 632307104   69,255,799 757,225 SH   SOLE   757,225 0 0
NAUTILUS BIOTECHNOLOGY INC COM 63909J108   37,026,980 12,594,211 SH   SOLE   12,594,211 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109   110,944,089 804,409 SH   SOLE   804,409 0 0
NEWAMSTERDAM PHARMA COMPANY ORDINARY SHARES N62509109   4,138,750 175,000 SH   SOLE   175,000 0 0
NOVAVAX INC COM NEW 670002401   3,346,000 700,000 SH Put SOLE   700,000 0 0
NUVALENT INC COM 670703107   209,009,561 2,783,454 SH   SOLE   2,783,454 0 0
OCULAR THERAPEUTIX INC COM 67576A100   30,252,659 3,324,468 SH   SOLE   3,324,468 0 0
ORCHESTRA BIOMED HLDGS INC COM 68572M106   13,416,793 2,545,881 SH   SOLE   2,545,881 0 0
PEPGEN INC COM 713317105   20,733,439 1,410,438 SH   SOLE   1,410,438 0 0
PRAXIS PRECISION MEDICINES I COM NEW 74006W207   50,133,361 821,589 SH   SOLE   821,589 0 0
PRECISION BIOSCIENCES INC COM NEW 74019P207   6,515,349 480,483 SH   SOLE   480,483 0 0
PROCEPT BIOROBOTICS CORP COM 74276L105   10,410,768 210,659 SH   SOLE   210,659 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102   28,765,764 994,323 SH   SOLE   994,323 0 0
RAPT THERAPEUTICS INC COM 75382E109   10,986,779 1,223,472 SH   SOLE   1,223,472 0 0
REVANCE THERAPEUTICS INC COM 761330109   2,952,000 600,000 SH   SOLE   600,000 0 0
REVOLUTION MEDICINES INC COM 76155X100   19,946,664 618,885 SH   SOLE   618,885 0 0
REVOLUTION MEDICINES INC *W EXP 12/17/202 76155X118   45,625 250,000 SH   SOLE   250,000 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105   141,627,528 3,268,579 SH   SOLE   3,268,579 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106   48,520,772 1,801,068 SH   SOLE   1,801,068 0 0
SAREPTA THERAPEUTICS INC COM 803607100   68,054,921 525,683 SH   SOLE   525,683 0 0
SINGULAR GENOMICS SYSTEMS IN COM 82933R100   1,093,648 2,126,893 SH   SOLE   2,126,893 0 0
SOLENO THERAPEUTICS INC COM 834203309   131,590,398 3,074,542 SH   SOLE   3,074,542 0 0
SOLID BIOSCIENCES INC COM NEW 83422E204   91,996,524 6,906,646 SH   SOLE   6,906,646 0 0
SPDR SER TR S&P BIOTECH 78464A870   4,744,500 50,000 SH Put SOLE   50,000 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107   111,358,380 2,262,462 SH   SOLE   2,262,462 0 0
SPYRE THERAPEUTICS INC COM NEW 00773J202   96,974,834 2,556,679 SH   SOLE   2,556,679 0 0
SURROZEN INC *W EXP 08/01/203 86889P117   5,033 166,666 SH   SOLE   166,666 0 0
SYROS PHARMACEUTICALS INC COM NEW 87184Q206   624,634 116,754 SH   SOLE   116,754 0 0
TACTILE SYS TECHNOLOGY INC COM 87357P100   14,675,131 903,085 SH   SOLE   903,085 0 0
TARSUS PHARMACEUTICALS INC COM 87650L103   47,124,722 1,296,416 SH   SOLE   1,296,416 0 0
TREACE MED CONCEPTS INC COM 89455T109   30,079,650 2,304,954 SH   SOLE   2,304,954 0 0
TRINITY BIOTECH PLC SPONS ADR NEW 896438504   3,672,000 1,800,000 SH   SOLE   1,800,000 0 0
TYRA BIOSCIENCES INC COM 90240B106   10,974,208 669,159 SH   SOLE   669,159 0 0
VAXCYTE INC COM 92243G108   132,026,767 1,932,759 SH   SOLE   1,932,759 0 0
VBI VACCINES INC CDA COM NEW 91822J202   757,026 1,261,710 SH   SOLE   1,261,710 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106   60,523,758 3,761,576 SH   SOLE   3,761,576 0 0
VERRICA PHARMACEUTICALS INC COM 92511W108   42,027,157 7,099,182 SH   SOLE   7,099,182 0 0
VERU INC COM 92536C103   3,909,848 5,584,699 SH   SOLE   5,584,699 0 0
VIKING THERAPEUTICS INC COM 92686J106   81,516,036 994,098 SH   SOLE   994,098 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104   64,035,803 3,657,099 SH   SOLE   3,657,099 0 0
X4 PHARMACEUTICALS INC COM 98420X103   4,928,181 3,545,454 SH   SOLE   3,545,454 0 0
XENON PHARMACEUTICALS INC COM 98420N105   38,409,554 892,208 SH   SOLE   892,208 0 0
ZYMEWORKS INC COM 98985Y108   11,306,970 1,074,807 SH   SOLE   1,074,807 0 0