The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABEONA THERAPEUTICS INC W EXP 12/24/201 00289Y115 5,145 659,636 SH   SOLE   659,636 0 0
ABEONA THERAPEUTICS INC COM 00289Y107 3,078 240,459 SH   SOLE   240,459 0 0
ABIOMED INC COM 003654100 10,704 23,800 SH   SOLE   23,800 0 0
ACCELERON PHARMA INC COM 00434H108 87,459 1,528,205 SH   SOLE   1,528,205 0 0
ACHILLION PHARMACEUTICALS IN COM 00448Q201 3,680 1,000,000 SH   SOLE   1,000,000 0 0
ADAMAS PHARMACEUTICALS INC COM 00548A106 8,449 422,015 SH   SOLE   422,015 0 0
ADAMIS PHARMACEUTICALS CORP COM NEW 00547W208 481 137,500 SH   SOLE   137,500 0 0
ADMA BIOLOGICS INC COM 000899104 40,496 6,521,102 SH   SOLE   6,521,102 0 0
AKEBIA THERAPEUTICS INC COM 00972D105 21,629 2,449,521 SH   SOLE   2,449,521 0 0
ALBIREO PHARMA INC COM 01345P106 56,175 1,704,330 SH   SOLE   1,704,330 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 42,579 3,085,458 SH   SOLE   3,085,458 0 0
ALLENA PHARMACEUTICALS INC COM 018119107 2,685 250,000 SH   SOLE   250,000 0 0
ALLIQUA BIOMEDICAL INC COM PAR 019621309 961 423,394 SH   SOLE   423,394 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 104,848 1,197,994 SH   SOLE   1,197,994 0 0
AMARIN CORP PLC SPONS ADR NEW 023111206 9,928 610,200 SH   SOLE   610,200 0 0
AMICUS THERAPEUTICS INC COM 03152W109 250,196 20,694,424 SH   SOLE   20,694,424 0 0
ANI PHARMACEUTICALS INC NOTE 3.000%12/0 00182CAA1 7,942 7,500,000 PRN   SOLE   7,500,000 0 0
AQUESTIVE THERAPEUTICS INC COM 03843E104 20,137 1,150,000 SH   SOLE   1,150,000 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 62,908 1,366,978 SH   SOLE   1,366,978 0 0
ARGENX SE SPONSORED ADR 04016X101 42,541 560,941 SH   SOLE   560,941 0 0
ARROWHEAD PHARMACEUTICALS INC COM 04280A100 7,006 365,445 SH   SOLE   365,445 0 0
ARVINAS INC COM 04335A105 2,109 125,000 SH   SOLE   125,000 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 76,008 1,072,647 SH   SOLE   1,072,647 0 0
ATHENEX INC COM 04685N103 44,592 2,869,528 SH   SOLE   2,869,528 0 0
BEIGENE LTD SPONSORED ADR 07725L102 982 5,700 SH   SOLE   5,700 0 0
BIOHAVEN PHARMACEUTICAL HLDG CO L COM G11196105 37,210 990,943 SH   SOLE   990,943 0 0
BIOLIFE SOLUTIONS INC COM 09062W204 514 29,376 SH   SOLE   29,376 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 73,466 941,147 SH   SOLE   941,147 0 0
CAPITAL SR LIVING CORP COM 140475104 946 100,173 SH   SOLE   100,173 0 0
CAPRICOR THERAPEUTICS INC COM 14070B101 4 4,000 SH   SOLE   4,000 0 0
CAREDX INC COM 14167L103 7,521 260,676 SH   SOLE   260,676 0 0
CASI PHARMACEUTICALS INC COM 14757U109 204 43,682 SH   SOLE   43,682 0 0
CLOVIS ONCOLOGY INC COM 189464100 4,406 150,000 SH   SOLE   150,000 0 0
CORIUM INTERNATIONAL INC COM 21887L107 60,456 6,357,133 SH   SOLE   6,357,133 0 0
CRINETICS PHARMACEUTICALS INC COM 22663K107 74,144 2,587,953 SH   SOLE   2,587,953 0 0
CYMABAY THERAPEUTICS INC COM 23257D103 30,390 2,742,821 SH   SOLE   2,742,821 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 49,242 2,661,715 SH   SOLE   2,661,715 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 67,604 3,009,998 SH   SOLE   3,009,998 0 0
DOVA PHARMACEUTICALS INC COM 25985T102 65,549 3,125,851 SH   SOLE   3,125,851 0 0
EHEALTH INC COM 28238P109 6,393 226,220 SH   SOLE   226,220 0 0
EIDOS THERAPEUTICS INC COM 28249H104 6,855 686,922 SH   SOLE   686,922 0 0
EIGER BIOPHARMACEUTICALS INC REGISTERED SHS COM 28249U105 1,892 157,679 SH   SOLE   157,679 0 0
ENDOCYTE INC REGISTERED SHS COM 29269A102 43,365 2,441,700 SH   SOLE   2,441,700 0 0
ESTABLISHMENT LABS HLDGS INC COM G31249108 15,304 635,000 SH   SOLE   635,000 0 0
EVOLENT HEALTH INC CL A 30050B101 3,124 110,000 SH   SOLE   110,000 0 0
FERRARI N.V. COM N3167Y103 849 6,200 SH   SOLE   6,200 0 0
FIAT CHRYSLER AUTOMOBILES N. COM N31738102 1,086 62,000 SH   SOLE   62,000 0 0
FOAMIX PHARMACEUTICALS LTD SHS M46135105 17,806 3,107,424 SH   SOLE   3,107,424 0 0
G1 THERAPEUTICS INC COM 3621LQ109 735 14,055 SH   SOLE   14,055 0 0
GERON CORP COM 374163103 3,680 1,950,000 SH Put SOLE   1,950,000 0 0
GERON CORP COM 374163103 10 200,000 SH Call SOLE   200,000 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 195,658 5,148,910 SH   SOLE   5,148,910 0 0
HISTOGENICS CORP COM 43358V109 656 1,203,399 SH   SOLE   1,203,399 0 0
HUMANA INC COM 444859102 11,848 35,000 SH   SOLE   35,000 0 0
HUTCHISON CHINA MEDITECH LTD SPONSORED ADR 44842L103 322 10,000 SH   SOLE   10,000 0 0
IMMUNOMEDICS INC COM 452907108 444 21,335 SH   SOLE   21,335 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 711 5,627 SH   SOLE   5,627 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 41,615 72,500 SH   SOLE   72,500 0 0
INVACARE CORP COM 461203101 2,910 200,000 SH   SOLE   200,000 0 0
INVITAE CORP COM 46185L103 31,136 1,861,100 SH   SOLE   1,861,100 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 82,014 7,290,199 SH   SOLE   7,290,199 0 0
IRHYTHM TECHNOLOGIES INC COM 450056106 15,992 168,939 SH   SOLE   168,939 0 0
KADMON HLDGS INC COM 48283N106 43,973 13,165,746 SH   SOLE   13,165,746 0 0
KINIKSA PHARMACEUTICALS LTD COM CL A G5269C101 1,356 53,169 SH   SOLE   53,169 0 0
LA JOLLA PHARMACEUTICAL CO COM par $.0001 2 503459604 86,833 4,313,611 SH   SOLE   4,313,611 0 0
LIVANOVA PLC SHS G5509L101 13,761 111,000 SH   SOLE   111,000 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 474 2,213 SH   SOLE   2,213 0 0
MARINUS PHARMACEUTICALS INC COM 56854Q101 9,077 907,732 SH   SOLE   907,732 0 0
MEIRAGTX HOLDINGS PLC COM G59665102 63,966 4,703,398 SH   SOLE   4,703,398 0 0
MERIT MED SYS INC COM 589889104 61,093 994,198 SH   SOLE   994,198 0 0
MOLECULAR TEMPLATES INC COM 608550109 10,641 1,974,133 SH   SOLE   1,974,133 0 0
MOMENTA PHARMACEUTICALS INC COM 60877T100 644 24,489 SH   SOLE   24,489 0 0
MOTUS GI HOLDINGS INC REGISTERED SHS COM 62014P108 14,333 2,810,542 SH   SOLE   2,810,542 0 0
MYOKARDIA INC COM 62857M105 71,014 1,089,169 SH   SOLE   1,089,169 0 0
NATERA INC COM 632307104 575 24,000 SH   SOLE   24,000 0 0
NEPTUNE WELLNESS SOLUTIONS I COM 64079L105 34,498 8,891,452 SH   SOLE   8,891,452 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 587,363 4,777,254 SH   SOLE   4,777,254 0 0
NEURONETICS INC COM 64131A105 4,345 135,500 SH   SOLE   135,500 0 0
NUVECTRA CORP COM 67075N108 2,967 135,000 SH   SOLE   135,000 0 0
ODONATE THERAPEUTICS INC COM 676079106 1,941 100,000 SH   SOLE   100,000 0 0
ONCOBIOLOGICS INC *W EXP 02/18/201 68235M113 6 420,875 SH   SOLE   420,875 0 0
ONCOMED PHARMACEUTICALS INC COM 68234X102 5,556 2,620,897 SH   SOLE   2,620,897 0 0
ONCOSEC MED INC COM 68234L207 70 50,000 SH   SOLE   50,000 0 0
PERNIX THERAPEUTICS HLDGS IN DBCV 4.250% 4/0 71426VAK4 413 1,000,000 PRN   SOLE   1,000,000 0 0
POLARITYTE INC COM 731094108 6,433 336,818 SH   SOLE   336,818 0 0
PROQR THERAPEUTICS N.V. SHS EURO N71542109 14,725 761,000 SH   SOLE   761,000 0 0
PROTAGONIST THERAPEUTICS INC COM 4366E1029 10,973 1,066,415 SH   SOLE   1,066,415 0 0
PROTEON THERAPEUTICS INC COM 74371L109 469 240,488 SH   SOLE   240,488 0 0
PTC THERAPEUTICS INC COM 69366J200 910 19,367 SH   SOLE   19,367 0 0
QUOTIENT LTD SHS G73268107 66,357 8,789,054 SH   SOLE   8,789,054 0 0
REATA PHARMACEUTICALS INC COM 75615P103 791 9,677 SH   SOLE   9,677 0 0
REGENXBIO INC COM 75901B107 35,536 470,672 SH   SOLE   470,672 0 0
RETROPHIN INC COM 761299106 60,483 3,212,871 SH   SOLE   3,212,871 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105 19,374 664,186 SH   SOLE   664,186 0 0
SENSEONICS HLDGS INC COM 81727U105 549 115,000 SH   SOLE   115,000 0 0
SIERRA ONCOLOGY INC COM 82640U107 5,440 3,200,000 SH   SOLE   3,200,000 0 0
SOLID BIOSCIENCES INC COM 3422E1055 40 1,835 SH Call SOLE   1,835 0 0
SOLID BIOSCIENCES INC COM 3422E1055 185,286 3,927,222 SH   SOLE   3,927,222 0 0
SYNLOGIC INC COM 87166L100 13,398 942,852 SH   SOLE   942,852 0 0
TABULA RASA HEALTHCARE INC COM 873379101 1,190 14,663 SH   SOLE   14,663 0 0
TESARO INC COM 881569107 7,802 200,000 SH   SOLE   200,000 0 0
THERAPEUTICSMD INC COM 88338N107 9,840 1,500,000 SH   SOLE   1,500,000 0 0
TRANSLATE BIO INC COM 89374L104 5,000 500,000 SH   SOLE   500,000 0 0
UNIQURE NV SHS N90064101 35,402 972,831 SH   SOLE   972,831 0 0
UROVANT SCIENCES LTD SHS G9381B108 5,552 462,659 SH   SOLE   462,659 0 0
VACCINEX INC COM 918640103 365 50,000 SH   SOLE   50,000 0 0
VBI VACCINES INC REGISTERED SHS COM 91822J103 23,391 9,665,843 SH   SOLE   9,665,843 0 0
VERICEL CORP COM 92346J108 385 27,211 SH   SOLE   27,211 0 0
VERRICA PHARMACEUTICALS INC COM 92511W108 55,419 3,410,412 SH   SOLE   3,410,412 0 0
VERU INC COM 92536C103 2,024 1,425,000 SH   SOLE   1,425,000 0 0
VIEWRAY INC REGISTERED SHS COM 92672L107 34,632 3,700,000 SH   SOLE   3,700,000 0 0
VIKING THERAPEUTICS INC COM 92686J106 1,119 64,261 SH   SOLE   64,261 0 0
WAVE LIFE SCIENCES LTD COM Y95308105 11,700 234,019 SH   SOLE   234,019 0 0
XENCOR INC COM 98401F105 32,271 828,095 SH   SOLE   828,095 0 0
XERIS PHARMACEUTICALS INC COM 98422L107 3,527 200,627 SH   SOLE   200,627 0 0
ZOGENIX INC COM 98978L204 188,858 3,807,632 SH   SOLE   3,807,632 0 0
ZYMEWORKS INC COM 98985W102 16,911 1,123,890 SH   SOLE   1,123,890 0 0