The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABEONA THERAPEUTICS INC W EXP 12/24/201 00289Y115 12,810 1,259,636 SH   SOLE 0 1,259,636 0 0
ABEONA THERAPEUTICS INC COM 00289Y107 954 59,662 SH   SOLE 0 59,662 0 0
ABIOMED INC COM 003654100 14,990 36,646 SH   SOLE 0 36,646 0 0
ACASTI PHARMA INC CL A NEW 00430K402 117 206,677 SH   SOLE 0 206,677 0 0
ACCELERON PHARMA INC COM 00434H108 74,149 1,528,205 SH   SOLE 0 1,528,205 0 0
ACHILLION PHARMACEUTICALS INC COM 00448Q201 2,830 1,000,000 SH   SOLE 0 1,000,000 0 0
ADAMAS PHARMACEUTICALS INC COM 00548A106 28,004 1,084,159 SH   SOLE 0 1,084,159 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 585 49,302 SH   SOLE 0 49,302 0 0
ADMA BIOLOGICS INC COM 000899104 29,410 6,521,102 SH   SOLE 0 6,521,102 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 428 80,845 SH   SOLE 0 80,845 0 0
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 272 25,694 SH   SOLE 0 25,694 0 0
AGILE THERAPEUTICS INC COM 00847L100 1,744 3,530,000 SH   SOLE 0 3,530,000 0 0
AKEBIA THERAPEUTICS INC COM 00972D105 22,110 2,215,400 SH   SOLE 0 2,215,400 0 0
ALBIREO PHARMA INC COM 01345P106 60,504 1,704,330 SH   SOLE 0 1,704,330 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 24,529 3,085,458 SH   SOLE 0 3,085,458 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 57,537 463,450 SH   SOLE 0 463,450 0 0
ALLENA PHARMACEUTICALS INC COM 018119107 3,258 250,000 SH   SOLE 0 250,000 0 0
ALLIQUA BIOMEDICAL INC COM PAR 019621309 867 423,394 SH   SOLE 0 423,394 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 181,902 1,846,911 SH   SOLE 0 1,846,911 0 0
AMICUS THERAPEUTICS INC COM 03152W109 312,782 20,024,424 SH   SOLE 0 20,024,424 0 0
ANI PHARMACEUTICALS INC NOTE 3.005 12/0 00182CAA1 8,458 7,500,000 PRN   SOLE 0 7,500,000 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 36,710 841,978 SH   SOLE 0 841,978 0 0
ARGENX SE ADR ADR 04016X101 43,879 529,560 SH   SOLE 0 529,560 0 0
ARRAY BIOPHARMA INC COM 04269X105 673 40,133 SH   SOLE 0 40,133 0 0
ARROWHEAD PHARMACEUTICALS INC COM 04280A100 4,970 365,445 SH   SOLE 0 365,445 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 71,352 1,072,647 SH   SOLE 0 1,072,647 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 5,909 150,695 SH   SOLE 0 150,695 0 0
ATHENAHEALTH INC COM 04685W103 23,871 150,000 SH   SOLE 0 150,000 0 0
ATHENEX INC COM 04685N103 3,545 190,000 SH   SOLE 0 190,000 0 0
AUDENTES THERAPEUTICS INC COM 05070R104 25,234 660,406 SH   SOLE 0 660,406 0 0
AVEO PHARMACEUTICALS INC COM 053588109 4,274 1,891,192 SH   SOLE 0 1,891,192 0 0
AXOGEN INC COM 05463X106 8,291 165,000 SH   SOLE 0 165,000 0 0
AZURRX BIOPHARMA INC COM 05502L105 730 227,272 SH   SOLE 0 227,272 0 0
BEIGENE LTD SPONSORED ADR 07725L102 876 5,700 SH   SOLE 0 5,700 0 0
BIOHAVEN PHARMACEUTICAL HOLDING CO L COM G11196105 108,429 2,743,647 SH   SOLE 0 2,743,647 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 61,014 961,147 SH   SOLE 0 961,147 0 0
CAPITAL SR LIVING CORP COM 140475104 1,069 100,173 SH   SOLE 0 100,173 0 0
CAPRICOR THERAPEUTICS INC COM 14070B101 5 4,000 SH   SOLE 0 4,000 0 0
CAREDX INC COM 14167L103 5,724 467,676 SH   SOLE 0 467,676 0 0
CASI PHARMACEUTICALS INC COM 14757U109 360 43,682 SH   SOLE 0 43,682 0 0
CHAMPIONS ONCOLOGY INC COM NEW 158990812 2,326 366,972 SH   SOLE 0 366,972 0 0
CLEARSIDE BIOMEDICAL INC COM 185063104 7,599 707,581 SH   SOLE 0 707,581 0 0
COLLEGIUM PHARMACEUTICAL INC COM 19459J104 577 24,213 SH   SOLE 0 24,213 0 0
CORIUM INTERNATIONAL INC COM 21887L107 50,921 6,357,133 SH   SOLE 0 6,357,133 0 0
CYMABAY THERAPEUTICS INC COM 23257D103 36,808 2,742,821 SH   SOLE 0 2,742,821 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 43,930 1,921,715 SH   SOLE 0 1,921,715 0 0
DBV TECHNOLOGIES SA SHS SPONSORED AMERICAN DEPOSIT ADR 23306J101 40,667 2,108,198 SH   SOLE 0 2,108,198 0 0
DOVA PHARMACEUTICALS INC COM 25985T102 93,525 3,125,851 SH   SOLE 0 3,125,851 0 0
EIDOS THERAPEUTICS INC COM 28249H104 13,971 686,922 SH   SOLE 0 686,922 0 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 1,923 157,679 SH   SOLE 0 157,679 0 0
ELLOX PHARMACEUTICALS INC COM 29014R103 50 2,961 SH   SOLE 0 2,961 0 0
ENDOCYTE INC COM 29269A102 26,519 1,921,700 SH   SOLE 0 1,921,700 0 0
EVOLENT HEALTH INC CL A 30050B101 1,474 70,000 SH   SOLE 0 70,000 0 0
FERRARI N.V. COM N3167Y103 837 6,200 SH   SOLE 0 6,200 0 0
FIAT CHRYSLER AUTOMOBILES N. SHS N31738102 1,171 62,000 SH   SOLE 0 62,000 0 0
FLEXION THERAPEUTICS INC COM 33938J106 7,962 307,989 SH   SOLE 0 307,989 0 0
FOAMIX PHARMACEUTICALS LTD SHS M46135105 5,598 1,117,324 SH   SOLE 0 1,117,324 0 0
G1 THERAPEUTICS INC COM 3621LQ109 611 14,055 SH   SOLE 0 14,055 0 0
GALAPAGOS NV SPON ADR 36315X101 13,908 150,875 SH   SOLE 0 150,875 0 0
GERON CORP COM 374163103 2,887 2,350,000 SH   SOLE 0 2,350,000 0 0
GERON CORP COM 374163103 35 200,000 SH   SOLE 0 200,000 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 218,266 4,828,910 SH   SOLE 0 4,828,910 0 0
GTX INC DEL COM NEW 40052B207 22,988 1,501,501 SH   SOLE 0 1,501,501 0 0
HISTOGENICS CORP COM 43358V109 5,508 2,203,277 SH   SOLE 0 2,203,277 0 0
HUMANA INC COM 444859102 44,114 148,218 SH   SOLE 0 148,218 0 0
HUTCHISON CHINA MEDITECH LTD SPONSORED ADR 44842L103 301 10,000 SH   SOLE 0 10,000 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 47,848 100,000 SH   SOLE 0 100,000 0 0
INVACARE CORP COM 461203101 3,720 200,000 SH   SOLE 0 200,000 0 0
INVITAE CORP COM 46185L103 14,855 2,021,100 SH   SOLE 0 2,021,100 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 74,908 5,852,202 SH   SOLE 0 5,852,202 0 0
IRHYTHM TECHNOLOGIES INC COM 450056106 24,989 308,006 SH   SOLE 0 308,006 0 0
KADMON HLDGS INC COM 48283N106 52,531 13,165,746 SH   SOLE 0 13,165,746 0 0
KINIKSA PHARMACEUTICALS LTD COM G5269C101 1,928 111,111 SH   SOLE 0 111,111 0 0
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 503459604 125,828 4,313,611 SH   SOLE 0 4,313,611 0 0
LOXO ONCOLOGY INC COM 548862101 653 3,765 SH   SOLE 0 3,765 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 9,010 32,213 SH   SOLE 0 32,213 0 0
MARINUS PHARMACEUTICALS INC COM 56854Q101 6,417 907,732 SH   SOLE 0 907,732 0 0
MEIRAGTX HOLDINGS PLC COM G59665102 53,900 4,703,398 SH   SOLE 0 4,703,398 0 0
MENLO THERAPEUTICS INC COM 586858102 10,079 1,241,287 SH   SOLE 0 1,241,287 0 0
MERIT MED SYS INC COM 589889104 55,399 1,082,013 SH   SOLE 0 1,082,013 0 0
MIRATI THERAPEUTICS INC COM 60468T105 35,160 713,191 SH   SOLE 0 713,191 0 0
MOLECULAR TEMPLATES INC COM 608550109 3,787 724,133 SH   SOLE 0 724,133 0 0
MOMENTA PHARMACEUTICALS INC COM 60877T100 501 24,489 SH   SOLE 0 24,489 0 0
MOTUS GI HLDGS INC COM 62014P108 20,207 2,810,542 SH   SOLE 0 2,810,542 0 0
MYOKARDIA INC COM 62857M105 54,078 1,089,169 SH   SOLE 0 1,089,169 0 0
NEKTAR THERAPEUTICS COM 640268108 296 6,057 SH   SOLE 0 6,057 0 0
NEPTUNE TECHNOLOGIES AND BIORESO COM 64077P108 20,379 8,574,015 SH   SOLE 0 8,574,015 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 463,226 4,715,250 SH   SOLE 0 4,715,250 0 0
NEURONETICS INC COM 64131A105 3,340 125,500 SH   SOLE 0 125,500 0 0
NUVECTRA CORP COM 67075N108 3,274 159,466 SH   SOLE 0 159,466 0 0
ODONATE THERAPEUTICS INC COM 676079106 3,312 150,000 SH   SOLE 0 150,000 0 0
ONCOMED PHARMACEUTICALS COM 68234X102 6,054 2,620,897 SH   SOLE 0 2,620,897 0 0
ONCOSEC MED INC COM 68234L207 69 50,000 SH   SOLE 0 50,000 0 0
PERNIX THERAPEUTICS HLDGS IN DBVC 4.250% 4/0 71426VAK4 426 1,000,000 PRN   SOLE 0 1,000,000 0 0
PROTEON THERAPEUTICS INC COM 74371L109 819 334,116 SH   SOLE 0 334,116 0 0
PTC THERAPEUTICS INC COM 69366J200 653 19,367 SH   SOLE 0 19,367 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 187 100,000 SH   SOLE 0 100,000 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 27,480 464,579 SH   SOLE 0 464,579 0 0
QUOTIENT LTD SHS G73268107 52,058 6,483,020 SH   SOLE 0 6,483,020 0 0
REGENXBIO INC COM 75901B107 62,215 867,106 SH   SOLE 0 867,106 0 0
RETROPHIN INC COM 761299106 57,387 3,212,871 SH   SOLE 0 3,212,871 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105 25,029 800,686 SH   SOLE 0 800,686 0 0
SANGAMO THERAPEUTICS INC COM 800677106 355 25,000 SH   SOLE 0 25,000 0 0
SENSEONICS HLDGS INC COM 81727U105 473 115,000 SH   SOLE 0 115,000 0 0
SIERRA ONCOLOGY INC COM 82640U107 13,320 4,500,000 SH   SOLE 0 4,500,000 0 0
SOLID BIOSCIENCES INC COM 3422E1055 139,927 3,927,222 SH   SOLE 0 3,927,222 0 0
STRONGBRIDGE BIOPHARMA PLC COM G85347105 1,650 275,000 SH   SOLE 0 275,000 0 0
SYNLOGIC INC COM 87166L100 9,268 942,852 SH   SOLE 0 942,852 0 0
TABULA RASA HEALTHCARE INC COM 873379101 936 14,663 SH   SOLE 0 14,663 0 0
TELADOC INC COM 87918A105 11,320 195,000 SH   SOLE 0 195,000 0 0
TESARO INC COM 881569107 4,447 100,000 SH   SOLE 0 100,000 0 0
TG THERAPEUTICS INC COM 88322Q108 258 100,000 SH   SOLE 0 100,000 0 0
TRANSLATE BIO INC COM 89374L104 6,325 500,000 SH   SOLE 0 500,000 0 0
UNIQURE NV SHS N90064101 54,607 1,444,628 SH   SOLE 0 1,444,628 0 0
VBI VACCINES INC COM NEW 91822J103 26,581 9,665,843 SH   SOLE 0 9,665,843 0 0
VERICEL CORP COM 92346J108 264 27,211 SH   SOLE 0 27,211 0 0
VERONA PHARMA PLC SPONSORED ADR 925050106 307 22,327 SH   SOLE 0 22,327 0 0
VERRICA PHARMACEUTICALS INC COM 92511W108 67,287 3,410,412 SH   SOLE 0 3,410,412 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 12,900 75,898 SH   SOLE 0 75,898 0 0
VICAL INC COM NEW 925602203 1,314 1,142,858 SH   SOLE 0 1,142,858 0 0
VIEWRAY INC COM 92672L107 519 75,000 SH   SOLE 0 75,000 0 0
VITAL THERAPIES INC COM 92847R104 405 150,000 SH   SOLE 0 150,000 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 10,817 282,798 SH   SOLE 0 282,798 0 0
XENCOR INC COM 98401F105 39,530 1,068,095 SH   SOLE 0 1,068,095 0 0
XERIS PHARMACEUTICALS INC COM 98422L107 8,541 450,000 SH   SOLE 0 450,000 0 0
ZOGENIX INC COM 98978L204 175,489 3,970,357 SH   SOLE 0 3,970,357 0 0
ZYMEWORKS INC COM 98985W102 15,920 1,123,890 SH   SOLE 0 1,123,890 0 0