Stockholders' Equity and Redeemable Convertible Preferred Stock (Details 2) - Stock Option [Member] $ / shares in Units, $ in Thousands	9 Months Ended
	Sep. 30, 2017 USD ($) $ / shares shares
Employee [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number of Shares [Roll Forward]
Outstanding at beginning | shares	310,091
Employee options granted | shares	15,788
Employee options expired | shares	(176)
Outstanding at ending | shares	325,703
Options vested and expected to vest | shares	325,703
Options vested and exercisable | shares	317,811
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Roll Forward]
Outstanding at beginning | $ / shares	$ 82.25
Employee options granted | $ / shares	1.02
Employee options expired | $ / shares
Outstanding at ending | $ / shares	78.24
Options vested and expected to vest | $ / shares	78.24
Options vested and exercisable | $ / shares	$ 80.15
Share-based Compensation Arrangement by Share-based Payment Award, Options, Total Intrinsic Value [Roll Forward]
Outstanding at beginning | $
Employee options granted | $	7,420
Employee options expired | $
Outstanding at ending | $	7,697
Options vested and expected to vest | $	7,697
Options vested and exercisable | $	$ 3,987
Share-based Compensation Arrangement by Share-based Payment Award, Options, Weighted Average Remaining Contractual Life [Roll Forward]
Outstanding at beginning	4 years 1 month 6 days
Employee options granted	4 years 8 months 12 days
Outstanding at ending	3 years 6 months
Options vested and expected to vest	3 years 6 months
Options vested and exercisable	3 years 4 months 24 days
Non-Employee [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number of Shares [Roll Forward]
Outstanding at beginning | shares	2,893
Employee options granted | shares
Outstanding at ending | shares	2,893
Options vested and expected to vest | shares	2,893
Options vested and exercisable | shares	2,893
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Roll Forward]
Outstanding at beginning | $ / shares	$ 98.07
Employee options granted | $ / shares
Outstanding at ending | $ / shares	98.07
Options vested and expected to vest | $ / shares	98.07
Options vested and exercisable | $ / shares	$ 98.07
Share-based Compensation Arrangement by Share-based Payment Award, Options, Total Intrinsic Value [Roll Forward]
Outstanding at beginning | $
Employee options granted | $
Outstanding at ending | $
Options vested and expected to vest | $
Options vested and exercisable | $
Share-based Compensation Arrangement by Share-based Payment Award, Options, Weighted Average Remaining Contractual Life [Roll Forward]
Outstanding at beginning	4 years 4 months 24 days
Outstanding at ending	3 years 8 months 12 days
Options vested and expected to vest	3 years 8 months 12 days
Options vested and exercisable	3 years 8 months 12 days