Stockholders' Equity and Redeemable Convertible Preferred Stock (Details 3) - Stock Option [Member]	12 Months Ended
	Dec. 31, 2016 USD ($) $ / shares shares
Employee [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number of Shares [Roll Forward]
Outstanding at beginning | shares	286,487
Employee options granted | shares	23,682
Employee options expired | shares	(78)
Outstanding at ending | shares	310,091
Options vested and expected to vest | shares	310,091
Options vested and exercisable | shares	302,199
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Roll Forward]
Outstanding at beginning | $ / shares	$ 89.07
Employee options granted | $ / shares	1.89
Employee options expired | $ / shares
Outstanding at ending | $ / shares	82.25
Options vested and expected to vest | $ / shares	82.25
Options vested and exercisable | $ / shares	$ 84.35
Share-based Compensation Arrangement by Share-based Payment Award, Options, Total Intrinsic Value [Roll Forward]
Outstanding at beginning | $
Employee options granted | $
Outstanding at ending | $
Options vested and expected to vest | $
Options vested and exercisable | $
Share-based Compensation Arrangement by Share-based Payment Award, Options, Weighted Average Remaining Contractual Life [Roll Forward]
Outstanding at beginning	5 years
Employee options granted	5 years 2 months 12 days
Outstanding at ending	4 years 1 month 6 days
Options vested and expected to vest	4 years 1 month 6 days
Options vested and exercisable	4 years 1 month 6 days
Non-Employee [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number of Shares [Roll Forward]
Outstanding at beginning | shares	2,893
Employee options granted | shares
Outstanding at ending | shares	2,893
Options vested and expected to vest | shares	2,893
Options vested and exercisable | shares	2,893
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Roll Forward]
Outstanding at beginning | $ / shares	$ 98.07
Employee options granted | $ / shares
Outstanding at ending | $ / shares	98.07
Options vested and expected to vest | $ / shares	98.07
Options vested and exercisable | $ / shares	$ 98.07
Share-based Compensation Arrangement by Share-based Payment Award, Options, Total Intrinsic Value [Roll Forward]
Outstanding at beginning | $
Employee options granted | $
Outstanding at ending | $
Options vested and expected to vest | $
Options vested and exercisable | $
Share-based Compensation Arrangement by Share-based Payment Award, Options, Weighted Average Remaining Contractual Life [Roll Forward]
Outstanding at beginning	5 years 4 months 24 days
Outstanding at ending	4 years 4 months 24 days
Options vested and expected to vest	4 years 4 months 24 days
Options vested and exercisable	4 years 4 months 24 days