POWERS OF ATTORNEY



KNOW ALL MEN BY THESE PRESENTS, that each person whose signature appears below hereby

constitutes and appoints Mark McDonnell his true and lawful attorney-in-fact, with full

power of substitution, to sign any and all instruments, certificates and documents that may

be necessary, desirable or appropriate to be executed on behalf of himself as an individual

or in his capacity as a general partner of any partnership, pursuant to Sections 13 and 16

of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), and any and all

regulations promulgated thereunder, and to file the same, with all exhibits thereto, and any

other documents in connection therewith, with the Securities and Exchange Commission, and

with any other entity when and if such is mandated by the Exchange Act or by the By-laws of

the National Association of Securities Dealers, Inc., granting unto said attorney-in-fact

full power and authority to do and perform each and every act and thing necessary, desirable

or appropriate, fully to all intents and purposes as he might or could do in person, thereby

ratifying and confirming all that said attorney-in-fact, or his substitutes, may lawfully do

or cause to be done by virtue hereof.



ARCH VENTURE FUND V, L.P.



By:  ARCH Venture Partners V, L.P.

Its General Partner



By:  ARCH Venture Partners V, LLC

Its General Partner



By:  /s/ Keith Crandell

Managing Director





ARCH VENTURE FUND III, L.P.



By:  ARCH Venture Partners, LLC

its General Partner



By:  /s/ Keith Crandell

Managing Director





ARCH VENTURE FUND II, L.P.



By:  ARCH Management Partners II, L.P.

Its General Partner



By:  ARCH Venture Partners, L.P.

Its General Partner



By:  ARCH Venture Corporation

Its General Partner



By:  /s/ Keith Crandell

Managing Director





ARCH V ENTREPRENEURS FUND V, L.P.



By:  ARCH Venture Partners V, L.P.

its General Partner



By:  ARCH Venture Partners V, LLC

Its General Partner



By:  /s/ Keith Crandell

Managing Director





HEALTHCARE FOCUS FUND, L.P.



By:  ARCH Venture Partners V, L.P.

its General Partner



By:  ARCH Venture Partners V, LLC

Its General Partner



By:  /s/ Keith Crandell

Managing Director





ARCH VENTURE PARTNERS V, L.P.



By:  ARCH Venture Partners V, LLC

Its General Partner



By:  /s/ Keith Crandell

Managing Director





ARCH VENTURE PARTNERS V, LLC



By:  /s/ Keith Crandell

Managing Director





ARCH VENTURE PARTNERS, LLC



By:  /s/ Keith Crandell

Managing Director



ARCH MANAGEMENT PARTNERS II, L.P.



By:  ARCH Venture Partners, L.P.

Its General Partner



By:  ARCH Venture Corporation

Its General Partner



By: /s/ Keith Crandell

Managing Director





ARCH VENTURE PARTNERS, L.P.



By:  ARCH Venture Corporation

Its General Partner



By:  /s/ Keith Crandell

Managing Director





ARCH VENTURE CORPORATION



By:  /s/ Keith Crandell

Managing Director





/s/ Steven Lazarus

 Steven Lazarus



/s/ Keith Crandell

Keith Crandell



/s/ Robert Nelsen

Robert Nelsen



/s/ Clinton Bybee

Clinton Bybee