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Fair Value Measurements - Financial Assets and Liabilities Measured at Fair Value on Recurring Basis (Detail) - Recurring [Member] - USD ($)
$ in Thousands
Sep. 30, 2018
Dec. 31, 2017
Assets    
Money market funds $ 20,993 $ 13,097
Liabilities    
Contingent consideration   1,672
Common stock warrant liability 11,612 18,712
Total liabilities 11,827 34,984
Perceptive Derivative Liability [Member]    
Liabilities    
Derivative liability 215  
JGB Derivative Liability [Member]    
Liabilities    
Derivative liability   14,600
Fair Value Measured Using - (Level 1) [Member]    
Assets    
Money market funds 20,993 13,097
Liabilities    
Contingent consideration   0
Common stock warrant liability 0 0
Total liabilities 0 0
Fair Value Measured Using - (Level 1) [Member] | Perceptive Derivative Liability [Member]    
Liabilities    
Derivative liability 0  
Fair Value Measured Using - (Level 1) [Member] | JGB Derivative Liability [Member]    
Liabilities    
Derivative liability   0
Fair Value Measured Using - (Level 2) [Member]    
Assets    
Money market funds 0 0
Liabilities    
Contingent consideration   0
Common stock warrant liability 0 0
Total liabilities 0 0
Fair Value Measured Using - (Level 2) [Member] | Perceptive Derivative Liability [Member]    
Liabilities    
Derivative liability 0  
Fair Value Measured Using - (Level 2) [Member] | JGB Derivative Liability [Member]    
Liabilities    
Derivative liability   0
Fair Value Measured Using - (Level 3) [Member]    
Assets    
Money market funds 0 0
Liabilities    
Contingent consideration   1,672
Common stock warrant liability 11,612 18,712
Total liabilities 11,827 34,984
Fair Value Measured Using - (Level 3) [Member] | Perceptive Derivative Liability [Member]    
Liabilities    
Derivative liability $ 215  
Fair Value Measured Using - (Level 3) [Member] | JGB Derivative Liability [Member]    
Liabilities    
Derivative liability   $ 14,600