Certification Pursuant to 18 U.S.C. 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002; provided by the Chief Executive Officer and Chief Financial Officer, based on each such officer’s knowledge and belief.

The undersigned officers of Nuveen Multi-Strategy Income and Growth Fund (the “Fund”) certify that, to the best of each such officer’s knowledge and belief:

1.	The Form N-CSR of the Fund for the period ended December 31, 2008 (the “Report”) fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and
2.	The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Fund.

Date: March 9, 2009

s/ Gifford R. Zimmerman  

Gifford R. Zimmerman 

Chief Administrative Officer
(principal executive officer) 

s/ Stephen D. Foy  

Stephen D. Foy 

Vice President, Controller
(principal financial officer)