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Note 1 - Organization and Summary of Significant Accounting Policies - Accrued Expenses (Details) - USD ($)
Dec. 31, 2022
Dec. 31, 2021
Employee wages and benefits $ 580,264 $ 405,758
Research and development expenses 343,457 194,250
Other 31,360 109,552
Accrued Liabilities, Current, Total $ 955,081 $ 709,560