Note 4 - Income Taxes (Tables)

12 Months Ended

Dec. 31, 2021

Notes Tables

Schedule of Income before Income Tax, Domestic and Foreign [Table Text Block]

	Years Ended December 31,
	2021			2020
U.S. operations	$	(13,115,869	)	$	(9,246,122	)
Foreign operations		45,618			(47,833	)
Total loss before provision for income taxes	$	(13,070,251	)	$	(9,293,955	)

Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]

	Years Ended December 31,
	2021			2020
Tax at U.S. statutory rate		(21.00	)%		(21.00	)%
State taxes, net of federal benefit		(4.52	)		(3.60	)
Non-deductible items		(0.84	)		(0.45	)
Change in valuation allowance		28.09			24.19
True-up adjustment		0.06			1.33
Foreign operations		0.09			(0.13	)
Change in tax rate		(1.88	)		—
Other		—			(0.34	)
Effective income tax rate		—	%		—	%

Schedule of Deferred Tax Assets and Liabilities [Table Text Block]

	December 31,
	2021			2020
Stock option expense	$	947,400		$	689,600
NOL carryforward		10,509,900			7,080,600
Research and development credits		1,656,500			1,656,500
Unrealized gain from investment in Alphazyme		(72,100	)		(69,800	)
Other		(6,100	)		7,900
Deferred tax asset, net of deferred tax liabilities		13,035,600			9,364,800
Valuation allowance		(13,035,600	)		(9,364,800	)
Net deferred tax asset	$	—		$	—