Exhibit 12.1

Epicept Corporation
Computation of Ratio of Earnings to Fixed Charges
(Dollars in Thousands)

																For the Nine
	Years Ended December 31,															Months Ended
	2003			2004			2005			2006			2007			September 30, 2008
Earnings:
Operating Loss		(10,035	)		(7,884	)		(7,499	)		(65,453	)		(28,689	)		(20,003	)
Fixed Charges		4,672			2,768			2,029			5,873			2,816			1,431
Earnings		(5,363	)		(5,116	)		(5,470	)		(59,580	)		(25,873	)		(18,572	)
Fixed Charges:
Interest Expense		4,593			2,670			1,906			5,046			1,772			868
Amort. of Debt		10			29			53			291			515			226
Rent Exp		69			69			70			536			529			337
Total of Fixed Charges		4,672			2,768			2,029			5,873			2,816			1,431
Ratio of earnings to fixed charges	Note 1			Note 1			Note 1			Note 1			Note 1			Note 1
Deficiency of earnings to fixed charges		(10,035	)		(7,884	)		(7,499	)		(65,453	)		(28,689	)		(20,003	)