0001209191-15-033295.txt : 20150408 0001209191-15-033295.hdr.sgml : 20150408 20150408212749 ACCESSION NUMBER: 0001209191-15-033295 CONFORMED SUBMISSION TYPE: 3 PUBLIC DOCUMENT COUNT: 10 CONFORMED PERIOD OF REPORT: 20150408 FILED AS OF DATE: 20150408 DATE AS OF CHANGE: 20150408 REPORTING-OWNER: OWNER DATA: COMPANY CONFORMED NAME: CLEVELAND BRUCE A CENTRAL INDEX KEY: 0001333063 FILING VALUES: FORM TYPE: 3 SEC ACT: 1934 Act SEC FILE NUMBER: 001-36830 FILM NUMBER: 15760239 MAIL ADDRESS: STREET 1: 2207 BRIDGEPOINTE PARKWAY CITY: SAN MATEO STATE: CA ZIP: 94404 REPORTING-OWNER: OWNER DATA: COMPANY CONFORMED NAME: Pepper Douglas A CENTRAL INDEX KEY: 0001381839 FILING VALUES: FORM TYPE: 3 SEC ACT: 1934 Act SEC FILE NUMBER: 001-36830 FILM NUMBER: 15760240 MAIL ADDRESS: STREET 1: C/O INTERWEST PARTNERS STREET 2: 2710 SAND HILL ROAD, SECOND FLOOR CITY: MENLO PARK STATE: CA ZIP: 94025 REPORTING-OWNER: OWNER DATA: COMPANY CONFORMED NAME: Kjellson Nina S CENTRAL INDEX KEY: 0001381980 FILING VALUES: FORM TYPE: 3 SEC ACT: 1934 Act SEC FILE NUMBER: 001-36830 FILM NUMBER: 15760241 MAIL ADDRESS: STREET 1: C/O INTERWEST PARTNERS STREET 2: 2710 SAND HILL ROAD, SECOND FLOOR CITY: MENLO PARK STATE: CA ZIP: 94025 REPORTING-OWNER: OWNER DATA: COMPANY CONFORMED NAME: Kliman Gilbert H CENTRAL INDEX KEY: 0001293171 FILING VALUES: FORM TYPE: 3 SEC ACT: 1934 Act SEC FILE NUMBER: 001-36830 FILM NUMBER: 15760243 MAIL ADDRESS: STREET 1: C/O INTERWEST PARTNERS STREET 2: 2710 SAND HILL ROAD, 2ND FLOOR CITY: MENLO PARK STATE: CA ZIP: 94025 REPORTING-OWNER: OWNER DATA: COMPANY CONFORMED NAME: ORONSKY ARNOLD L CENTRAL INDEX KEY: 0001207833 FILING VALUES: FORM TYPE: 3 SEC ACT: 1934 Act SEC FILE NUMBER: 001-36830 FILM NUMBER: 15760244 MAIL ADDRESS: STREET 1: C/O INTERWEST PARTNERS STREET 2: 2710 SAND HILL ROAD, 2ND FLOOR CITY: MENLO PARK STATE: CA ZIP: 94025 REPORTING-OWNER: OWNER DATA: COMPANY CONFORMED NAME: GIANOS PHILIP T CENTRAL INDEX KEY: 0001207831 FILING VALUES: FORM TYPE: 3 SEC ACT: 1934 Act SEC FILE NUMBER: 001-36830 FILM NUMBER: 15760245 REPORTING-OWNER: OWNER DATA: COMPANY CONFORMED NAME: InterWest Partners IX, LP CENTRAL INDEX KEY: 0001398928 STATE OF INCORPORATION: CA FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 3 SEC ACT: 1934 Act SEC FILE NUMBER: 001-36830 FILM NUMBER: 15760246 BUSINESS ADDRESS: STREET 1: 2710 SAND HILL ROAD STREET 2: SECOND FLOOR CITY: MENLO PARK STATE: CA ZIP: 94025 BUSINESS PHONE: 650-854-8585 MAIL ADDRESS: STREET 1: 2710 SAND HILL ROAD STREET 2: SECOND FLOOR CITY: MENLO PARK STATE: CA ZIP: 94025 REPORTING-OWNER: OWNER DATA: COMPANY CONFORMED NAME: InterWest Management Partners IX, LLC CENTRAL INDEX KEY: 0001398927 STATE OF INCORPORATION: CA FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 3 SEC ACT: 1934 Act SEC FILE NUMBER: 001-36830 FILM NUMBER: 15760247 BUSINESS ADDRESS: STREET 1: 2710 SAND HILL ROAD STREET 2: SECOND FLOOR CITY: MENLO PARK STATE: CA ZIP: 94025 BUSINESS PHONE: 650-854-8585 MAIL ADDRESS: STREET 1: 2710 SAND HILL ROAD STREET 2: SECOND FLOOR CITY: MENLO PARK STATE: CA ZIP: 94025 REPORTING-OWNER: OWNER DATA: COMPANY CONFORMED NAME: NASR KHALED CENTRAL INDEX KEY: 0001276600 FILING VALUES: FORM TYPE: 3 SEC ACT: 1934 Act SEC FILE NUMBER: 001-36830 FILM NUMBER: 15760238 MAIL ADDRESS: STREET 1: ONE EMBARCADERO CENTER STE 3700 CITY: SAN FRANCISCO STATE: CA ZIP: 94111 REPORTING-OWNER: OWNER DATA: COMPANY CONFORMED NAME: Holmes W Stephen CENTRAL INDEX KEY: 0001293923 FILING VALUES: FORM TYPE: 3 SEC ACT: 1934 Act SEC FILE NUMBER: 001-36830 FILM NUMBER: 15760242 MAIL ADDRESS: STREET 1: C/O INTERWEST PARTNERS STREET 2: 2710 SAND HILL ROAD, 2ND FLOOR CITY: MENLO PARK STATE: CA ZIP: 94025 ISSUER: COMPANY DATA: COMPANY CONFORMED NAME: Carbylan Therapeutics, Inc. CENTRAL INDEX KEY: 0001348911 STANDARD INDUSTRIAL CLASSIFICATION: PHARMACEUTICAL PREPARATIONS [2834] IRS NUMBER: 000000000 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 BUSINESS ADDRESS: STREET 1: 3181 PORTER DRIVE CITY: PALO ALTO STATE: CA ZIP: 94304 BUSINESS PHONE: 650-855-6777 MAIL ADDRESS: STREET 1: 3181 PORTER DRIVE CITY: PALO ALTO STATE: CA ZIP: 94304 FORMER COMPANY: FORMER CONFORMED NAME: Carbylan Biosurgery, Inc DATE OF NAME CHANGE: 20130102 FORMER COMPANY: FORMER CONFORMED NAME: Carbylan Biosurgery Inc DATE OF NAME CHANGE: 20060105 3 1 doc3.xml FORM 3 SUBMISSION X0206 3 2015-04-08 0 0001348911 Carbylan Therapeutics, Inc. CBYL 0001398927 InterWest Management Partners IX, LLC C/O INTERWEST PARTNERS 2710 SAND HILL ROAD, SUITE 200 MENLO PARK CA 94025 0 0 1 0 0001398928 InterWest Partners IX, LP C/O INTERWEST PARTNERS 2710 SAND HILL ROAD, SUITE 200 MENLO PARK CA 94025 0 0 1 0 0001207831 GIANOS PHILIP T C/O INTERWEST PARTNERS 2710 SAND HILL ROAD, SUITE 200 MENLO PARK CA 94025 0 0 1 0 0001207833 ORONSKY ARNOLD L C/O INTERWEST PARTNERS 2710 SAND HILL ROAD, SUITE 200 MENLO PARK CA 94025 0 0 1 0 0001293171 Kliman Gilbert H C/O INTERWEST PARTNERS 2710 SAND HILL ROAD, SUITE 200 MENLO PARK CA 94025 0 0 1 0 0001293923 Holmes W Stephen C/O INTERWEST PARTNERS 2710 SAND HILL ROAD, SUITE 200 MENLO PARK CA 94025 0 0 1 0 0001381980 Kjellson Nina S C/O INTERWEST PARTNERS 2710 SAND HILL ROAD, SUITE 200 MENLO PARK CA 94025 0 0 1 0 0001381839 Pepper Douglas A C/O INTERWEST PARTNERS 2710 SAND HILL ROAD, SUITE 200 MENLO PARK CA 94025 0 0 1 0 0001333063 CLEVELAND BRUCE A C/O INTERWEST PARTNERS 2710 SAND HILL ROAD, SUITE 200 MENLO PARK CA 94025 0 0 1 0 0001276600 NASR KHALED C/O INTERWEST PARTNERS 2710 SAND HILL ROAD, SUITE 200 MENLO PARK CA 94025 0 0 1 0 Convertible Series A Preferred Stock Common 831531 I See Footnote Convertible Series B Preferred Stock Common 2145351 I See Footnote Convertible Promissory Note Common 466357 I See Footnote Convertible Promissory Note Common 365957 I See Footnote The Series A Convertible Preferred Stock is convertible into Common Stock on a one for one basis, at any time at the holder's election, and automatically upon the closing of the Issuer's initial public offering, and has no expiration date. The shares are held by InterWest Partners IX, L.P. ("IW9"). InterWest Management Partners IX, LLC ("IMP9"), the general partner of IW9, has sole voting and investment control over the shares held by IW9. Philip T. Gianos, W. Stephen Holmes, Gilbert H. Kliman and Arnold Oronsky are the managing directors of IMP9. Bruce A. Cleveland, Nina Kjellson, Khaled A. Nasr and Douglas A. Pepper are the venture members of IMP9. Each of the managing directors and venture members share voting and investment control with respect to the share held by IW9 and disclaims beneficial ownership of the shares reported herein, except to the extent of his or her respective pecuniary interest therein. The Series B Convertible Preferred Stock is convertible into Common Stock on a one for one basis, at any time at the holder's election, and automatically upon the closing of the Issuer's initial public offering, and has no expiration date. The Convertible Promissory Note is convertible into the number of shares of the Issuer's Common Stock equal to the quotient obtained by dividing the entire principal amount and 184 days of accrued interest on the Convertible Promissory Note by 80% of the initial public offering price of $5.00 per share of the Issuer's Common Stock, automatically upon the closing of the Issuer's initial public offering, and has no expiration date. The Convertible Promissory Note is convertible into the number of shares of the Issuer's Common Stock equal to the quotient obtained by dividing the entire principal amount and 41 days of accrued interest on the Convertible Promissory Note by 80% of the initial public offering price of $5.00 per share of the Issuer's Common Stock, automatically upon the closing of the Issuer's initial public offering, and has no expiration date. Exhibit List Exhibit 24 - Powers of Attorney Exhibit 99 - Form 3 Joint Filter Information By: /s/ W. Stephen Holmes, as managing director of InterWest Management Partners IX, LLC 2015-04-08 By: /s/ W. Stephen Holmes, as managing director of InterWest Management Partners IX, LLC, the General Partner of InterWest Partners IX, L.P. 2015-04-08 By: /s/ Karen A. Wilson, Attorney-in-Fact for Philip T. Gianos 2015-04-08 By: /s/ Karen A. Wilson, Attorney-in-Fact for Arnold L. Oronsky 2015-04-08 By: /s/ Karen A. Wilson, Attorney-in-Fact for Gilbert H. Kliman 2015-04-08 By: /s/ Karen A. Wilson, Attorney-in-Fact for W. Stephen Holmes 2015-04-08 By: /s/ Karen A. Wilson, Attorney-in-Fact for Nina Kjellson 2015-04-08 By: /s/ Karen A. Wilson, Attorney-in-Fact for Douglas Pepper 2015-04-08 By: /s/ Karen A. Wilson, Attorney-in-Fact for Bruce Cleveland 2015-04-08 By: /s/ Karen A. Wilson, Attorney-in-Fact for Khaled Nasr 2015-04-08 EX-24.1 2 attachment1.htm EX-24.1 DOCUMENT 
                               POWER OF ATTORNEY

KNOW ALL BY THESE PRESENTS:

The undersigned, Philip T. Gianos, hereby constitutes and appoints Karen A.
Wilson as his true and lawful Attorney-in-Fact, with full power in his name and
on his behalf, to take all actions and do all things necessary with respect to
all matters arising in connection with the ownership reporting requirements of
the securities laws of the United States, including the execution and delivery
of all documents in connection therewith.

The undersigned agrees to indemnify said Attorney-in-Fact against, and hold her
free and harmless from, and all loss, cost, expense, damage or liability which
she may incur or sustain as a result of any action taken by her in good faith
pursuant to this Power of Attorney.

This Power of Attorney shall remain in full force and effect until revoked in
writing by the undersigned and the authority granted herein may be relied upon
by any person until such person has actually received written notice of
revocation.

IN WITNESS WHEREOF, the undersigned has executed this Power of Attorney this
28th day of May, 1996.


                                        PHILIP T. GIANOS


                                        /s/ Philip T. Gianos
                                        ---------------------------------------
EX-24.2 3 attachment2.htm EX-24.2 DOCUMENT 
                               POWER OF ATTORNEY


KNOW ALL BY THESE PRESENTS:

The undersigned, Arnold L. Oronsky, hereby constitutes and appoints Karen A.
Wilson as his true and lawful Attorney-in-Fact, with full power in his name and
on his behalf, to take all actions and do all things necessary with respect to
all matters arising in connection with the ownership reporting requirements of
the securities laws of the United States, including the execution and delivery
of all documents in connection therewith.

The undersigned agrees to indemnify said Attorney-in-Fact against, and hold her
free and harmless from, and all loss, cost, expense, damage or liability which
she may incur or sustain as a result of any action taken by her in good faith
pursuant to this Power of Attorney.

This Power of Attorney shall remain in full force and effect until revoked in
writing by the undersigned and the authority granted herein may be relied upon
by any person until such person has actually received written notice of
revocation.

IN WITNESS WHEREOF, the undersigned has executed this Power of Attorney this
28th day of May, 1996.


                                        ARNOLD L. ORONSKY


                                        /s/ Arnold L. Oronsky
                                        ---------------------------------------
EX-24.3 4 attachment3.htm EX-24.3 DOCUMENT 
                               POWER OF ATTORNEY


KNOW ALL BY THESE PRESENTS:

The undersigned, Gilbert H. Kliman, hereby constitutes and appoints Karen A.
Wilson as his true and lawful Attorney-in-Fact, with full power in his name and
on his behalf, to take all actions and do all things necessary with respect to
all matters arising in connection with the ownership reporting requirements of
the securities laws of the United States, including the execution and delivery
of all documents in connection therewith.

The undersigned agrees to indemnify said Attorney-in-Fact against, and hold her
free and harmless from, and all loss, cost, expense, damage or liability which
she may incur or sustain as a result of any action taken by her in good faith
pursuant to this Power of Attorney.

This Power of Attorney shall remain in full force and effect until revoked in
writing by the undersigned and the authority granted herein may be relied upon
by any person until such person has actually received written notice of
revocation.

IN WITNESS WHEREOF, the undersigned has executed this Power of Attorney this 8th
day of September, 2000.


                                        GILBERT H. KLIMAN


                                        /s/ Gilbert H. Kliman
                                        ---------------------------------------
EX-24.4 5 attachment4.htm EX-24.4 DOCUMENT 
                               POWER OF ATTORNEY


KNOW ALL BY THESE PRESENTS:

The undersigned, W. Stephen Holmes, hereby constitutes and appoints Karen A.
Wilson as his true and lawful Attorney-in-Fact, with full power in his name and
on his behalf, to take all actions and do all things necessary with respect to
all matters arising in connection with the ownership reporting requirements of
the securities laws of the United States, including the execution and delivery
of all documents in connection therewith.

The undersigned agrees to indemnify said Attorney-in-Fact against, and hold her
free and harmless from, and all loss, cost, expense, damage or liability which
she may incur or sustain as a result of any action taken by her in good faith
pursuant to this Power of Attorney.

This Power of Attorney shall remain in full force and effect until revoked in
writing by the undersigned and the authority granted herein may be relied upon
by any person until such person has actually received written notice of
revocation.

IN WITNESS WHEREOF, the undersigned has executed this Power of Attorney this
28th day of May, 1996.


                                        W. STEPHEN HOLMES


                                        /s/ W. Stephen Holmes
                                        ---------------------------------------
EX-24.5 6 attachment5.htm EX-24.5 DOCUMENT 
                               POWER OF ATTORNEY


KNOW ALL BY THESE PRESENTS:

The undersigned, Nina S. Kjellson, hereby constitutes and appoints Karen A.
Wilson as her true and lawful Attorney-in-Fact, with full power in her name and
on her behalf, to take all actions and do all things necessary with respect to
all matters arising in connection with the ownership reporting requirements of
the securities laws of the United States, including the execution and delivery
of all documents in connection therewith.

The undersigned agrees to indemnify said Attorney-in-Fact against, and hold her
free and harmless from, and all loss, cost, expense, damage or liability which
she may incur or sustain as a result of any action taken by her in good faith
pursuant to this Power of Attorney.

This Power of Attorney shall remain in full force and effect until revoked in
writing by the undersigned and the authority granted herein may be relied upon
by any person until such person has actually received written notice of
revocation.

IN WITNESS WHEREOF, the undersigned has executed this Power of Attorney this
31st day of May, 2007.


                                        NINA S. KJELLSON


                                        /s/ Nina S. Kjellson
                                        --------------------------------------
EX-24.6 7 attachment6.htm EX-24.6 DOCUMENT 
                               POWER OF ATTORNEY


KNOW ALL BY THESE PRESENTS:

The undersigned, Douglas A. Pepper, hereby constitutes and appoints Karen A.
Wilson as his true and lawful Attorney-in-Fact, with full power in his name and
on his behalf, to take all actions and do all things necessary with respect to
all matters arising in connection with the ownership reporting requirements of
the securities laws of the United States, including the execution and delivery
of all documents in connection therewith.

The undersigned agrees to indemnify said Attorney-in-Fact against, and hold her
free and harmless from, and all loss, cost, expense, damage or liability which
she may incur or sustain as a result of any action taken by her in good faith
pursuant to this Power of Attorney.

This Power of Attorney shall remain in full force and effect until revoked in
writing by the undersigned and the authority granted herein may be relied upon
by any person until such person has actually received written notice of
revocation.

IN WITNESS WHEREOF, the undersigned has executed this Power of Attorney this 1st
day of June, 2007.


                                        DOUGLAS A. PEPPER


                                        /s/ Douglas A. Pepper
                                        ---------------------------------------
EX-24.7 8 attachment7.htm EX-24.7 DOCUMENT 
                               POWER OF ATTORNEY


KNOW ALL BY THESE PRESENTS:

The undersigned, Bruce A. Cleveland, hereby constitutes and appoints Karen A.
Wilson as his true and lawful Attorney-in-Fact, with full power in his name and
on his behalf, to take all actions and do all things necessary with respect to
all matters arising in connection with the ownership reporting requirements of
the securities laws of the United States, including the execution and delivery
of all documents in connection therewith.

The undersigned agrees to indemnify said Attorney-in-Fact against, and hold her
free and harmless from, and all loss, cost, expense, damage or liability which
she may incur or sustain as a result of any action taken by her in good faith
pursuant to this Power of Attorney.

This Power of Attorney shall remain in full force and effect until revoked in
writing by the undersigned and the authority granted herein may be relied upon
by any person until such person has actually received written notice of
revocation.

IN WITNESS WHEREOF, the undersigned has executed this Power of Attorney this
31st day of May, 2007.


                                        BRUCE A. CLEVELAND


                                        /s/ Bruce A. Cleveland
                                        ---------------------------------------
EX-24.8 9 attachment8.htm EX-24.8 DOCUMENT 
                               POWER OF ATTORNEY


KNOW ALL BY THESE PRESENTS:

The undersigned, Khaled A. Nasr, hereby constitutes and appoints Karen A. Wilson
as his true and lawful Attorney-in-Fact, with full power in his name and on his
behalf, to take all actions and do all things necessary with respect to all
matters arising in connection with the ownership reporting requirements of the
securities laws of the United States, including the execution and delivery of
all documents in connection therewith.

The undersigned agrees to indemnify said Attorney-in-Fact against, and hold her
free and harmless from, and all loss, cost, expense, damage or liability which
she may incur or sustain as a result of any action taken by her in good faith
pursuant to this Power of Attorney.

This Power of Attorney shall remain in full force and effect until revoked in
writing by the undersigned and the authority granted herein may be relied upon
by any person until such person has actually received written notice of
revocation.

IN WITNESS WHEREOF, the undersigned has executed this Power of Attorney this
31st day of May, 2007.


                                        KHALED A. NASR


                                        /s/ Khaled A. Nasr
                                        ---------------------------------------
EX-99 10 attachment9.htm EX-99 DOCUMENT 
                                                                      Exhibit 99

                            FORM 3 JOINT FILER INFORMATION

Name of
"Reporting Persons":        InterWest Partners IX, L.P. ("IW9")
                            InterWest Management Partners IX, LLC ("IMP9")

                            Bruce A. Cleveland
                            Philip T. Gianos
                            W. Stephen Holmes
                            Nina Kjellson
                            Gilbert H. Kliman
                            Arnold L. Oronsky
                            Khaled Nasr
                            Douglas A. Pepper

Address:                    2710 Sand Hill Road, Suite 200
                            Menlo Park, CA  94025

Designated Filer:           InterWest Partners IX, L.P.

Issuer and Ticker Symbol:   Carbylan Therapeutics, Inc. ("CBYL")

Date of Event:              April 8, 2015

Each of the following is a Joint Filer with InterWest Partners IX L.P. ("IW9")
and may be deemed to share indirect beneficial ownership in the securities set
forth on the attached Form 3:

InterWest Management Partners IX, LLC ("IMP9") is the general partner of IW9 and
has sole voting and investment control over the shares owned by IW9. Philip T.
Gianos, W. Stephen Holmes, Gilbert H. Kliman, and Arnold L. Oronsky are Managing
Directors of IMP9 and, Bruce A. Cleveland, Nina Kjellson, Douglas A. Pepper and
Khaled A. Nasr are Venture Members of IMP9.

All Reporting Persons disclaim beneficial ownership of shares of Carbylan
Therapeutics, Inc. stock held by IW9, except to the extent of their respective
pecuniary interest therein. The filing of this statement shall not be deemed an
admission that, for purposes of Section 16 of the Securities Exchange Act of
1934, or otherwise, any of the Reporting Persons are the beneficial owner of all
of the equity securities covered by this statement.

Each of the Reporting Persons listed above has designated InterWest Partners IX,
L.P. as its designated filer of Forms 3, 4 and 5 in accordance with Section
16(a) of the Securities Exchange Act of 1934 and the rules thereunder. Each
Reporting Person has appointed InterWest Management Partners IX, LLC as its
attorney in fact for the purpose of making reports relating to transaction in
Carbylan Therapeutics, Inc. Common Stock.

INTERWEST MANAGEMENT PARTNERS           INTERWEST PARTNERS IX, LP
IX, L.L.C.

                                        By:  InterWest Management Partners IX,
                                             LLC
By:  /s/ W. Stephen Holmes                   Its General Partner
   ----------------------------------
     W. Stephen Holmes,
     Managing Director

                                        By:  /s/ W. Stephen Holmes
                                           -------------------------------------
                                             W. Stephen Holmes, Managing
                                             Director


Bruce A. Cleveland, an individual       Gilbert H. Kliman, an individual
By: InterWest Management Partners IX,   By: InterWest Management Partners IX,
    LLC,                                    LLC,
    as Attorney-in-Fact                      as Attorney-in-Fact

By:  /s/ Karen A. Wilson                By:  /s/ Karen A. Wilson
   -----------------------------------     -------------------------------------
     Karen A. Wilson, Power of Attorney      Karen A. Wilson, Power of Attorney

Philip T. Gianos, an individual         Arnold L. Oronsky, an individual
By: InterWest Management Partners IX,   By: InterWest Management Partners IX,
    LLC,                                    LLC,
    as Attorney-in-Fact                     as Attorney-in-Fact

By:  /s/ Karen A. Wilson                By:  /s/ Karen A. Wilson
   -----------------------------------     -------------------------------------
     Karen A. Wilson, Power of Attorney      Karen A. Wilson, Power of Attorney

W. Stephen Holmes, an individual        Khaled A. Nasr, an individual
By: InterWest Management Partners IX,   By: InterWest Management Partners IX,
    LLC,                                    LLC,
    as Attorney-in-Fact                     as Attorney-in-Fact

By:  /s/ Karen A. Wilson                By:  /s/ Karen A. Wilson
   -----------------------------------       -----------------------------------
     Karen A. Wilson, Power of Attorney      Karen A. Wilson, Power of Attorney

Nina Kjellson, an individual            Douglas A. Pepper, an individual
By: InterWest Management Partners IX,   By: InterWest Management Partners IX,
    LLC,                                    LLC,
    as Attorney-in-Fact                     as Attorney-in-Fact

By:  /s/ Karen A. Wilson                By:  /s/ Karen A. Wilson
   -----------------------------------     -------------------------------------
     Karen A. Wilson, Power of Attorney      Karen A. Wilson, Power of Attorney