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Stock Plans, Share-Based Payments and Warrants (Details Narrative) - USD ($)
$ / shares in Units, $ in Thousands
3 Months Ended 12 Months Ended
Mar. 31, 2019
Mar. 31, 2018
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2015
Dec. 31, 2016
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]            
Common stock, shares authorized 90,000,000   90,000,000 90,000,000    
Options outstanding     7,434,561 6,770,777   4,592,347
Stock options granted     1,143,034 2,311,542    
Share-based compensation expense     $ 525 $ 456    
Weighted-average fair value of options granted     $ 0.48 $ 0.36    
Share-based compensation arrangement by share-based payment award, options, outstanding, intrinsic value     $ 441 $ 170    
Share-based compensation arrangement by share-based payment award, options, vested and expected to vest, outstanding, aggregate intrinsic value     $ 425 $ 162    
Share-based compensation arrangement by share-based payment award, options, vested and expected to vest, outstanding, weighted average remaining contractual term     7 years 2 months 30 days 7 years 9 months 18 days    
Employee service share-based compensation, nonvested awards, compensation not yet recognized, stock options $ 1,193   $ 1,311      
Employee service share-based compensation, nonvested awards, compensation recognized at the time of certain performance conditions met 230   230      
Stock based compensation recognized amortization cost $ 963   $ 1,081      
Employee service share-based compensation, nonvested awards, compensation cost not yet recognized, period for recognition 2 years   2 years 2 months 12 days      
Fair value of restricted stock     $ 377 $ 345    
Selling, general and administrative expense $ 1,503 $ 1,260 $ 4,517 $ 3,298    
Restricted Stock [Member]            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]            
Stock options granted     449,043 817,144    
Share-based compensation expense 15 112 $ 460 $ 316    
Weighted-average fair value of options granted     $ 0.62 $ 0.50    
Employee service share-based compensation, nonvested awards, compensation not yet recognized, stock options     $ 87      
Employee service share-based compensation, nonvested awards, compensation cost not yet recognized, period for recognition       6 months    
Selling, general and administrative expense 14 100 416 $ 264    
Research and Development Expense $ 1 $ 12 44 52    
Selling, General and Administrative Expenses [Member]            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]            
Share-based compensation expense     500 426    
Research and Development Expenses [Member]            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]            
Share-based compensation expense     $ 25 $ 30    
2015 Equity Incentive Plan [Member]            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]            
Number of shares reserved and authorized for awards         7,000,000  
2015 Equity Incentive Plan [Member] | Options [Member]            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]            
Options outstanding     6,369,425      
Stock option plan terms and description     The options issued to employees expire on various dates between April 15, 2025 and December 31, 2028      
Stock option vesting term description     Options currently outstanding are fully vested or will vest upon a combination of the following: immediate vesting, performance-based vesting or straight-line vesting of two or four years.      
Stock options granted     6,399,425      
Stock options will vest upon the specified performance condition is met     1,845,447      
2015 Equity Incentive Plan [Member] | Options [Member] | Option and Restricted Stock [Member]            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]            
Shares available for future grants     460,917      
2015 Equity Incentive Plan [Member] | Options [Member] | Non Employees [Member]            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]            
Options outstanding     30,000      
Stock option plan terms and description     Will expire on May 31, 2021      
2015 Equity Incentive Plan [Member] | Maximum [Member]            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]            
Common stock, shares authorized       10,000,000    
Stock options contractual term         10 years  
2004 Stock Incentive Plan [Member] | Options [Member]            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]            
Options outstanding     1,035,136      
Stock option plan terms and description     The options expire on various dates between January 6, 2019 and March 26, 2024.      
Stock option vesting term description     Options currently outstanding are fully vested      
2004 Stock Incentive Plan [Member] | Non Employee Stock Options [Member]            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]            
Options outstanding     447,500      
Stock option plan terms and description     Options expire at various dates between March 24, 2021 and November 17, 2024