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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2023
Dec. 31, 2022
Dec. 31, 2021
Operating Activities      
Net loss $ (134,661) $ (99,195) $ (49,593)
Adjustments to reconcile net loss to net cash (used in) provided operating activities:      
Depreciation 8,742 6,664 4,749
Amortization of intangible assets 24,912 24,912 24,912
Amortization of right-of-use lease assets 4,324 4,370 4,760
Amortization of debt issuance costs 1,373 1,373 1,373
Deferred income tax benefit (120) (54) (1,029)
Loss (gain) on disposal of fixed assets 893 (24) 7
Stock-based compensation 43,528 38,561 30,146
Unrealized foreign currency (gains) losses (980) 2,242 2,313
(Accretion of discount) amortization of premium on short-term investments (1,685) 731 1,028
Other liabilities 3,049 785 2,465
Acquired in-process R&D acquired through the issuance of common stock 3,000    
Changes in operating assets and liabilities:      
Accounts receivable, net (3,843) (3,138) 1,700
Inventory (4,830) (15,472) (7,703)
Prepaid expenses and other current assets (885) (1,720) (3,054)
Accounts payable and accrued liabilities 1,305 7,210 12,448
Other assets (1,880) (328) 186
Net cash (used in) provided by operating activities (57,758) (33,083) 24,708
Investing activities      
Purchases of property and equipment (20,248) (30,265) (47,785)
Purchases of short-term investments (265,587) (59,256) (215,285)
Proceeds from sales and maturities of short-term investments 303,100 135,157 206,916
Proceeds from disposal of property and equipment   151 3
Investment in company-owned life insurance (3,170) (1,008) (2,081)
Net cash provided by (used in) investing activities 14,095 44,779 (58,232)
Financing activities      
Proceeds from exercise of stock options 12,748 3,577 26,124
Share purchases under Employee Stock Purchase Plan 6,278 5,630 4,817
Payment of employee taxes related to vested restricted stock units (3,273) (2,730) (3,690)
Proceeds from tenant improvement allowance   301 12,668
Principal paid on finance lease (711) (527) (659)
Net cash provided by financing activities 15,042 6,251 39,260
Effect of exchange rate changes on cash and cash equivalents 1,341 (1,468) (1,774)
Net (decrease) increase in cash, cash equivalents and restricted cash (27,280) 16,479 3,962
Cash, cash equivalents and restricted cash at beginning of period 126,603 110,124 106,162
Cash, cash equivalents and restricted cash at end of period 99,323 126,603 110,124
Supplemental disclosures of cash flow information      
Taxes paid, net of refunds 1,557 522 272
Interest paid on convertible senior notes 7,906 7,906 7,907
Other interest paid 4,348 4,434 4,074
Supplemental schedule of noncash investing and financing activities      
Purchases of property and equipment included in accounts payable and accrued liabilities $ 1,333 $ 3,797 $ 2,263