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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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 333ufHzyE0xukIUVupwdbQ==

<SEC-DOCUMENT>0001225208-06-001771.txt : 20060317
<SEC-HEADER>0001225208-06-001771.hdr.sgml : 20060317
<ACCEPTANCE-DATETIME>20060317162252
ACCESSION NUMBER:		0001225208-06-001771
CONFORMED SUBMISSION TYPE:	4/A
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20060222
FILED AS OF DATE:		20060317
DATE AS OF CHANGE:		20060317

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			LIFEPOINT HOSPITALS, INC.
		CENTRAL INDEX KEY:			0001301611
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-GENERAL MEDICAL & SURGICAL HOSPITALS, NEC [8062]
		IRS NUMBER:				201538254
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		103 POWELL COURT
		STREET 2:		SUITE 200
		CITY:			BRENTWOOD
		STATE:			TN
		ZIP:			37027
		BUSINESS PHONE:		615-372-8500

	MAIL ADDRESS:	
		STREET 1:		103 POWELL COURT
		STREET 2:		SUITE 200
		CITY:			BRENTWOOD
		STATE:			TN
		ZIP:			37027

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Lakers Holding Corp.
		DATE OF NAME CHANGE:	20040826

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			DONAHEY KENNETH C
		CENTRAL INDEX KEY:			0001189139

	FILING VALUES:
		FORM TYPE:		4/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-51251
		FILM NUMBER:		06696231

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		6153728500

	MAIL ADDRESS:	
		STREET 1:		103 POWELL COURT SUITE 200
		CITY:			BRENTWOOD
		STATE:			TN
		ZIP:			37027
</SEC-HEADER>
<DOCUMENT>
<TYPE>4/A
<SEQUENCE>1
<FILENAME>doc4a.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4/A</documentType>

    <periodOfReport>2006-02-22</periodOfReport>

    <dateOfOriginalSubmission>2006-02-24</dateOfOriginalSubmission>

    <issuer>
        <issuerCik>0001301611</issuerCik>
        <issuerName>LIFEPOINT HOSPITALS, INC.</issuerName>
        <issuerTradingSymbol>LPNT</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001189139</rptOwnerCik>
            <rptOwnerName>DONAHEY KENNETH C</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>103 POWELL COURT</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 200</rptOwnerStreet2>
            <rptOwnerCity>BRENTWOOD</rptOwnerCity>
            <rptOwnerState>TN</rptOwnerState>
            <rptOwnerZipCode>37027</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>1</isOfficer>
            <officerTitle>Chairman, CEO and Pres.</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable></nonDerivativeTable>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Non-Qualified Stock Options (Right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>33.02</value>
                <footnoteId id="F1"/>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2006-02-22</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>100000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <value>2009-02-22</value>
                <footnoteId id="F2"/>
            </exerciseDate>
            <expirationDate>
                <value>2016-02-22</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>100000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>100000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">This option grant was previously reported with an exercise price of $32.63, the closing price of the Company's stock on the date of grant.  The correct exercise price for the grant is $33.02, the closing sales price of the Company's stock on the trading day immediately preceding the date of grant.</footnote>
        <footnote id="F2">Options become exercisable in three equal installments on February 22, 2007, February 22, 2008 and February 22, 2009.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>Kenneth C. Donahey</signatureName>
        <signatureDate>2006-03-17</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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