Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Operating activities
Net loss	$ (147,417)	$ (116,889)
Adjustments to reconcile net loss to net cash used in operating activities:
Amortization of debt discount and deferred financing	1,295	1,200
Depreciation and amortization	2,745	3,171
Stock-based compensation	43,114	32,090
Non-cash changes in the fair value of contingent consideration payable	(1,073)	1,492
Foreign currency remeasurement loss	353	3,235
Asset impairment charges and other asset write-offs	12,265	0
Changes in operating assets and liabilities:
Accounts receivable	(4,424)	(3,127)
Inventories	3,537	(4,445)
Prepaid expenses and other current assets	(4,481)	5,265
Accounts payable, accrued expenses, and other current liabilities	22,671	(28,485)
Other non-current assets and liabilities	(2,762)	(1,784)
Net cash used in operating activities	(74,177)	(108,277)
Investing activities
Sale and redemption of marketable securities	184,061	258,767
Purchases of marketable securities	(98,330)	(145,255)
Capital expenditures	(1,226)	(1,234)
Net cash provided by investing activities	84,505	112,278
Financing activities
Payment of finance leases	(41)	(389)
Proceeds from warrants exercised	0	19,230
Purchase of vested restricted stock units, net of taxes	(9,278)	(14,438)
Proceeds from stock options exercised, net	1,858	6,661
Net cash (used in) provided by financing activities	(7,461)	11,064
Effect of exchange rate changes on cash, cash equivalents, and restricted cash	(12,462)	(1,439)
Net (decrease) increase in cash, cash equivalents, and restricted cash at the end of the period	(9,595)	13,626
Cash, cash equivalents, and restricted cash at the beginning of period	249,456	166,162
Cash, cash equivalents, and restricted cash at the end of period	239,861	179,788
Supplemental disclosures of cash flow information
Cash paid during the period for interest	15,108	15,109
Cash paid for taxes	710	4,526
Capital expenditures unpaid at the end of period	53	191
Tenant improvements paid through lease incentives	$ 0	$ 67