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Summary of Significant Accounting Policies - Foreign Currency Transactions (Details) - USD ($)
$ in Thousands
9 Months Ended
Sep. 30, 2018
Sep. 30, 2017
Dec. 31, 2017
New Accounting Pronouncements or Change in Accounting Principle [Line Items]      
Total stockholders’ equity $ 410,951   $ 352,850
Retained earnings (accumulated deficit) (1,334,141)   $ (1,063,610)
Net cash used in operating activities (239,278) $ (140,661)  
Accounting Standards Update 2018-02      
New Accounting Pronouncements or Change in Accounting Principle [Line Items]      
Retained earnings (accumulated deficit) 383    
Accounting Standards Update 2016-18      
New Accounting Pronouncements or Change in Accounting Principle [Line Items]      
Net cash used in operating activities   $ 1,100  
Accumulated Foreign Currency Adjustment Attributable | Accounting Standards Update 2018-02      
New Accounting Pronouncements or Change in Accounting Principle [Line Items]      
Total stockholders’ equity $ (383)