Income Taxes (Details) (USD $)	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012
Current deferred tax asset
Non-cash stock issue	$ 8,172,000	$ 7,100,000
Others	1,343,000	1,257,000
Total current deferred tax asset	9,515,000	8,357,000
Non-current deferred tax assets
Amortization/depreciation	3,068,000	3,176,000
Research tax credit	13,680,000	9,072,000
Net operating loss carry forwards	79,984,000	62,060,000
Deferred revenue	14,649,000	12,149,000
Others	682,000	520,000
Gross deferred tax assets	121,578,000	95,334,000
Deferred tax liability related to business acquisition	(9,186,000)
Total net deferred tax asset	112,392,000	95,334,000
Less valuation allowance	(121,578,000)	(95,334,000)
Net deferred tax assets (liability)	(9,186,000)
Increase in the valuation allowance	$ 26,300,000	$ 20,100,000