8-K

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

FORM 8-K

CURRENT REPORT
Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): February 5, 2010

AMICUS THERAPEUTICS, INC.
(Exact name of registrant as specified in its charter)

Delaware	001-33497	71-0869350
(State or other Jurisdiction of Incorporation)	(Commission File Number)	(IRS Employer Identification No.)

6 Cedar Brook Drive, Cranbury, NJ	08512
(Address of Principal Executive Offices)	(Zip Code)

Registrant’s telephone number, including area code: (609) 662-2000

(Former name or former address if changed since last report.)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

o Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

o Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

o Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

o Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Item 8.01. Other Events.

On February 5, 2010, Amicus Therapeutics, Inc. issued a press release, a copy of which is attached to this Current Report as Exhibit 99.1.

Item 9.01. Financial Statements and Exhibits.

(d) Exhibits: The Exhibit Index annexed hereto is incorporated herein by reference.

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

Amicus Therapeutics, Inc.

Date: February 5, 2010

By:    /s/ Geoffrey P. Gilmore                           

Geoffrey P. Gilmore
Senior Vice President and General Counsel

EXHIBIT INDEX

Exhibit No.	Description
99.1	Press Release dated February 5, 2010

EX-99.1

Exhibit 99.1

Amicus Therapeutics Board of Directors Names Chief Executive Officer John F. Crowley Chairman of the Board

Donald J. Hayden, Jr. elected Lead Independent Director

Cranbury, NJ, February 5, 2010 – Amicus Therapeutics (NASDAQ: FOLD) announced today that its Board of Directors has elected John F. Crowley as Chairman of the Board in addition to his current role as Chief Executive Officer (CEO), effective immediately. Mr. Crowley will succeed Donald J. Hayden, Jr., who will become the Lead Independent Director of the Board.

”The Board’s decision to elect Mr. Crowley as Chairman of the Board reflects our confidence in his leadership and vision for Amicus. Additionally, the Board recognized the value of the strong independent leadership provided by Mr. Hayden during his tenure as Chairman which will be preserved through his appointment as Lead Independent Director,” stated Alexander Barkas, Ph.D., Amicus Board of Director and Member of Governance and Nominating Committee.

In his role as Chairman of the Board, Mr. Crowley will lead the Board’s efforts in overseeing the development and implementation of the Company’s strategic vision.

As Lead Independent Director, Mr. Hayden will be responsible for, among other things, leading executive sessions of the Board’s independent directors, advising the independent board committee chairs in fulfilling their responsibilities to the Board, assisting the Board and the Company’s Officers in complying with Amicus’ governance guidelines and overseeing the process of evaluating, developing and compensating the CEO. A copy of the Lead Independent Director Charter describing in full Mr. Hayden’s roles and responsibilities is available on the Amicus website at www.amicustherapeutics.com.

About Amicus Therapeutics

Amicus Therapeutics is developing orally-administered, small molecule drugs called pharmacological chaperones, a novel, first-in-class approach to treating a broad range of diseases including lysosomal storage disorders and diseases of neurodegeneration.  Amicus’ lead program is in Phase 3 for the treatment of Fabry disease. 

CONTACTS:

Investors/Media:
Jenene Thomas
Director, Investor Relations
(609) 662-5084