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Customers that Represent Greater than Ten Percent of Gross Revenues (Detail) - Revenue from Rights Concentration Risk - Gross Revenues
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Sanofi Genzyme      
Concentration Risk [Line Items]      
Concentration risk percentage 58.00% 61.00% 68.00%
Vir Biotechnology      
Concentration Risk [Line Items]      
Concentration risk percentage 16.00%    
MDCO      
Concentration Risk [Line Items]      
Concentration risk percentage   34.00% 24.00%
Distributor A      
Concentration Risk [Line Items]      
Concentration risk percentage 13.00%