CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2024	Sep. 30, 2023	Sep. 30, 2024	Sep. 30, 2023
Revenues:
Total revenues	$ 500,919	$ 750,530	$ 1,655,077	$ 1,388,574
Operating costs and expenses:
Cost of goods sold	81,980	79,473	203,864	196,241
Cost of collaborations and royalties	3,925	4,836	16,689	28,307
Research and development	270,926	253,179	826,063	732,274
Selling, general and administrative	220,993	199,175	680,187	597,523
Total operating costs and expenses	577,824	536,663	1,726,803	1,554,345
(Loss) income from operations	(76,905)	213,867	(71,726)	(165,771)
Other (expense) income:
Interest expense	(34,376)	(30,893)	(102,887)	(89,883)
Interest income	32,146	25,425	90,973	65,155
Other expense, net	(29,528)	(57,658)	(99,777)	(105,331)
Total other expense, net	(31,758)	(63,126)	(111,691)	(130,059)
(Loss) income before income taxes	(108,663)	150,741	(183,417)	(295,830)
Provision for income taxes	(2,907)	(2,988)	(10,977)	(6,542)
Net (loss) income	$ (111,570)	$ 147,753	$ (194,394)	$ (302,372)
Net (loss) income per common share - basic (in dollars per share)	$ (0.87)	$ 1.18	$ (1.53)	$ (2.43)
Net (loss) income per common share - diluted (in dollars per share)	$ (0.87)	$ 1.15	$ (1.53)	$ (2.43)
Weighted-average common shares- basic (in shares)	128,590	125,220	127,159	124,667
Weighted-average common shares - diluted (in shares)	128,590	131,337	127,159	124,667
Statements of Comprehensive (Loss) Income
Net (loss) income	$ (111,570)	$ 147,753	$ (194,394)	$ (302,372)
Other comprehensive income (loss):
Unrealized gain on marketable securities	9,078	1,878	4,783	3,978
Foreign currency translation gain (loss)	703	2,873	(6,327)	8,356
Defined benefit pension plans, net of tax	30	(10)	93	(19)
Total other comprehensive income (loss)	9,811	4,741	(1,451)	12,315
Comprehensive (loss) income	(101,759)	152,494	(195,845)	(290,057)
Net product revenues
Revenues:
Total revenues	420,146	313,153	1,195,397	895,186
Net revenues from collaborations
Revenues:
Total revenues	57,387	427,472	403,273	469,778
Royalty revenue
Revenues:
Total revenues	$ 23,386	$ 9,905	$ 56,407	$ 23,610