CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2024	Jun. 30, 2023	Jun. 30, 2024	Jun. 30, 2023
Revenues:
Total revenues	$ 659,825	$ 318,754	$ 1,154,158	$ 638,044
Operating costs and expenses:
Cost of goods sold	67,271	75,336	121,884	116,768
Cost of collaborations and royalties	1,401	10,034	12,764	23,471
Research and development	294,142	248,526	555,137	479,095
Selling, general and administrative	248,397	214,689	459,194	398,348
Total operating costs and expenses	611,211	548,585	1,148,979	1,017,682
Income (loss) from operations	48,614	(229,831)	5,179	(379,638)
Other (expense) income:
Interest expense	(33,258)	(30,035)	(68,511)	(58,990)
Interest income	29,182	21,075	58,827	39,730
Other expense, net	(55,705)	(35,418)	(70,249)	(47,673)
Total other expense, net	(59,781)	(44,378)	(79,933)	(66,933)
Loss before income taxes	(11,167)	(274,209)	(74,754)	(446,571)
Provision for income taxes	(5,722)	(1,815)	(8,070)	(3,554)
Net loss	$ (16,889)	$ (276,024)	$ (82,824)	$ (450,125)
Net loss per common share - basic (in dollars per share)	$ (0.13)	$ (2.21)	$ (0.66)	$ (3.62)
Net loss per common share - diluted (in dollars per share)	$ (0.13)	$ (2.21)	$ (0.66)	$ (3.62)
Weighted-average common shares - basic (in shares)	126,733	124,659	126,435	124,387
Weighted-average common shares - diluted (in shares)	126,733	124,659	126,435	124,387
Statements of Comprehensive Loss
Net loss	$ (16,889)	$ (276,024)	$ (82,824)	$ (450,125)
Other comprehensive (loss) income:
Unrealized (loss) gain on marketable securities	(727)	(2,025)	(4,295)	2,100
Foreign currency translation (loss) gain	(6,952)	4,073	(7,030)	5,483
Defined benefit pension plans, net of tax	30	(4)	63	(9)
Total other comprehensive (loss) income	(7,649)	2,044	(11,262)	7,574
Comprehensive loss	(24,538)	(273,980)	(94,086)	(442,551)
Net product revenues
Revenues:
Total revenues	410,088	305,705	775,251	582,033
Net revenues from collaborations
Revenues:
Total revenues	227,338	5,844	345,886	42,306
Royalty revenue
Revenues:
Total revenues	$ 22,399	$ 7,205	$ 33,021	$ 13,705