CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Dec. 31, 2023	Dec. 31, 2022
Current assets:
Cash and cash equivalents	$ 812,688	$ 866,394
Marketable debt securities	1,615,516	1,297,890
Marketable equity securities	11,178	28,122
Accounts receivable, net	327,787	237,963
Inventory	89,146	128,962
Prepaid expenses and other current assets	126,382	132,916
Total current assets	2,982,697	2,692,247
Property, plant and equipment, net	526,057	523,494
Operating lease right-of-use assets	199,732	215,136
Restricted investments	49,391	49,390
Other assets	72,003	66,092
Total assets	3,829,880	3,546,359
Current liabilities:
Accounts payable	55,519	98,094
Accrued expenses	713,013	545,460
Operating lease liability	41,510	41,967
Deferred revenue	102,753	42,105
Liability related to the sale of future royalties	54,991	40,289
Total current liabilities	967,786	767,915
Operating lease liability, net of current portion	243,101	261,339
Deferred revenue, net of current portion	188,175	193,791
Convertible debt	1,020,776	1,016,942
Liability related to the sale of future royalties, net of current portion	1,322,248	1,252,015
Other liabilities	308,438	212,580
Total liabilities	4,050,524	3,704,582
Commitments and contingencies (Note 13)
Stockholders’ deficit:
Preferred stock, $0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of December 31, 2023 and December 31, 2022	0	0
Common stock, $0.01 par value per share, 250,000 shares authorized as of December 31, 2023 and December 31, 2022, respectively; 125,794 shares issued and outstanding as of December 31, 2023; 123,925 shares issued and outstanding as of December 31, 2022	1,259	1,240
Additional paid-in capital	6,811,063	6,454,540
Accumulated other comprehensive loss	(23,375)	(44,654)
Accumulated deficit	(7,009,591)	(6,569,349)
Total stockholders’ deficit	(220,644)	(158,223)
Total liabilities and stockholders’ deficit	$ 3,829,880	$ 3,546,359