CONDENSED CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Mar. 31, 2023	Dec. 31, 2022
Current assets:
Cash and cash equivalents	$ 672,245	$ 866,394
Marketable debt securities	1,372,574	1,297,890
Marketable equity securities	25,856	28,122
Accounts receivable, net	219,434	237,963
Inventory	131,879	128,962
Prepaid expenses and other current assets	119,030	132,916
Total current assets	2,541,018	2,692,247
Property, plant and equipment, net	523,032	523,494
Operating lease right-of-use assets	215,049	215,136
Restricted investments	49,388	49,390
Other assets	63,453	66,092
Total assets	3,391,940	3,546,359
Current liabilities:
Accounts payable	62,237	98,094
Accrued expenses	508,599	545,460
Operating lease liability	43,055	41,967
Deferred revenue	35,794	42,105
Liability related to the sale of future royalties	23,706	40,289
Total current liabilities	673,391	767,915
Operating lease liability, net of current portion	259,399	261,339
Deferred revenue, net of current portion	191,257	193,791
Convertible debt	1,017,887	1,016,942
Liability related to the sale of future royalties, net of current portion	1,285,200	1,252,015
Other liabilities	224,046	212,580
Total liabilities	3,651,180	3,704,582
Commitments and contingencies (Note 13)
Stockholders’ deficit:
Preferred stock, $0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of March 31, 2023 and December 31, 2022	0	0
Common stock, $0.01 par value per share, 250,000 shares authorized; 124,241 shares issued and outstanding as of March 31, 2023; 123,925 shares issued and outstanding as of December 31, 2022	1,243	1,240
Additional paid-in capital	6,522,091	6,454,540
Accumulated other comprehensive loss	(39,124)	(44,654)
Accumulated deficit	(6,743,450)	(6,569,349)
Total stockholders’ deficit	(259,240)	(158,223)
Total liabilities and stockholders’ deficit	$ 3,391,940	$ 3,546,359