CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Revenues:
Total revenues	$ 844,287	$ 492,853	$ 219,750
Operating costs and expenses:
Cost of goods sold	115,005	74,185	25,062
Cost of collaborations and royalties	25,139	3,867	0
Research and development	792,156	654,819	655,114
Selling, general and administrative	620,639	588,420	479,005
Total operating costs and expenses	1,552,939	1,321,291	1,159,181
Loss from operations	(708,652)	(828,438)	(939,431)
Other (expense) income:
Interest expense	(143,021)	(84,496)	0
Interest income	1,579	11,809	33,448
Other (expense) income, net	(2,050)	45,525	20,730
Total other (expense) income, net	(143,492)	(27,162)	54,178
Loss before income taxes	(852,144)	(855,600)	(885,253)
Benefit (provision) for income taxes	(680)	(2,681)	(863)
Net loss	$ (852,824)	$ (858,281)	$ (886,116)
Net loss per share, basic (in dollars per share)	$ (7.20)	$ (7.46)	$ (8.11)
Net loss per share, diluted (in dollars per share)	$ (7.20)	$ (7.46)	$ (8.11)
Weighted average common shares, basic (in shares)	118,451,000	114,986,000	109,264,000
Weighted average common shares, diluted (in shares)	118,451,000	114,986,000	109,264,000
Statements of Comprehensive Loss
Net loss	$ (852,824)	$ (858,281)	$ (886,116)
Other comprehensive income (loss):
Unrealized (loss) gain on marketable securities	(1,978)	211	558
Foreign currency translation gain (loss)	11,398	(7,081)	(343)
Defined benefit pension plans, net of tax	943	(234)	(3,520)
Total other comprehensive income (loss)	10,363	(7,104)	(3,305)
Comprehensive loss	(842,461)	(865,385)	(889,421)
Net revenues from collaborations
Revenues:
Total revenues	180,953	131,333	53,213
Net product revenues
Revenues:
Total revenues	662,138	361,520	166,537
Royalty revenue
Revenues:
Total revenues	$ 1,196	$ 0	$ 0