OTHER BALANCE SHEET DETAILS (Tables)

12 Months Ended

Dec. 31, 2020

Balance Sheet Related Disclosures [Abstract]

The components of inventory are summarized as follows:


	As of December 31,
(In thousands)	2020		2019
Raw materials	$	63,460	$	15,418
Work in process	16,149		38,275
Finished goods	12,693		2,655
Total inventory	$	92,302	$	56,348

Property, Plant and Equipment, Net

Property, plant and equipment, net consist of the following:


	As of December 31,
(In thousands)	2020		2019
Buildings	$	262,637	$	250,380
Leasehold improvements	149,505		132,632
Laboratory equipment	48,930		29,755
Manufacturing equipment	41,089		—
Construction in progress	28,005		54,195
Computer equipment and software	19,064		14,956
Furniture and fixtures	11,066		10,339
Land	9,080		9,080
	569,376		501,337
Less: accumulated depreciation	(104,347)		(76,158)
Total	$	465,029	$	425,179

Accrued Expenses

Accrued expenses consist of the following:


	As of December 31,
(In thousands)	2020		2019
Compensation and related	$	97,433	$	68,304
Product rebates and discounts	94,242		32,670
Pre-clinical, clinical trial and manufacturing	46,506		34,269
Contingent liabilities	41,216		—
Licensing and collaboration agreements	15,424		20,622
Consulting and professional services	11,501		14,251
Other	49,587		27,085
Total	$	355,909	$	197,201

Cash, Cash Equivalents and Restricted Cash

Schedule of Reconciliation of Cash, Cash Equivalents and Restricted Cash

The following table provides a reconciliation of cash, cash equivalents and restricted cash reported within our consolidated balance sheets that sum to the total of these amounts shown in the consolidated statements of cash flows:


	As of December 31,
(In thousands)	2020		2019		2018
Cash and cash equivalents	$	496,580	$	547,178	$	420,146
Total restricted cash included in prepaid expenses, other current assets and long-term other assets	2,466		2,450		2,485
Total cash, cash equivalents, and restricted cash shown in the consolidated statements of cash flows	$	499,046	$	549,628	$	422,631

Accumulated Other Comprehensive (Loss) Income

Summary of Changes in Accumulated Other Comprehensive Income (Loss)

The following table summarizes the changes in accumulated other comprehensive (loss) income, by component:


(In thousands)	Loss on Investment in Joint Venture		Defined Benefit Pension Plans, Net of Tax		Unrealized (Losses) Gains from Debt Securities		Foreign Currency Translation Adjustment		Total Accumulated Other Comprehensive (Loss) Income
Balance as of December 31, 2018	$	(32,792)	$	—	$	(421)	$	—	$	(33,213)
Other comprehensive (loss) income before reclassifications	—		(3,661)		22		(343)		(3,982)
Amounts reclassified from other comprehensive income	—		141		536		—		677
Net other comprehensive (loss) income	—		(3,520)		558		(343)		(3,305)
Balance as of December 31, 2019	(32,792)		(3,520)		137		(343)		(36,518)
Other comprehensive (loss) income before reclassifications	—		(531)		(14)		(7,081)		(7,626)
Amounts reclassified from other comprehensive income	—		297		225		—		522
Net other comprehensive (loss) income	—		(234)		211		(7,081)		(7,104)
Balance as of December 31, 2020	$	(32,792)	$	(3,754)	$	348	$	(7,424)	$	(43,622)