CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2019	Sep. 30, 2018	Sep. 30, 2019	Sep. 30, 2018
Revenues:
Total revenues	$ 70,061	$ 2,069	$ 148,069	$ 53,875
Costs and expenses:
Cost of goods sold	5,213	137	12,886	137
Research and development	160,796	139,945	453,813	374,384
Selling, general and administrative	120,351	116,545	322,728	273,671
Total costs and expenses	286,360	256,627	789,427	648,192
Loss from operations	(216,299)	(254,558)	(641,358)	(594,317)
Other income (expense):
Interest income	9,889	6,796	26,195	18,691
Other (expense) income	(2,519)	2,925	(2,929)	5,468
Change in fair value of liability obligation	0	0	9,422	0
Gain on litigation settlement	0	0	0	20,564
Total other income	7,370	9,721	32,688	44,723
Loss before income taxes	(208,929)	(244,837)	(608,670)	(549,594)
Benefit (provision) for income taxes	394	(445)	(1,261)	(462)
Net loss	$ (208,535)	$ (245,282)	$ (609,931)	$ (550,056)
Net loss per common share - basic and diluted (in dollars per share)	$ (1.92)	$ (2.43)	$ (5.63)	$ (5.48)
Weighted-average common shares used to compute basic and diluted net loss per common share (in shares)	108,701	100,783	108,427	100,430
Comprehensive loss:
Net loss	$ (208,535)	$ (245,282)	$ (609,931)	$ (550,056)
Unrealized (loss) gain on marketable securities, net of tax	(50)	415	772	1,041
Foreign currency translation	1,439	0	2,281	0
Defined benefit pension plans	71	0	(4,211)	0
Comprehensive loss	(207,075)	(244,867)	(611,089)	(549,015)
Net Revenues from Collaborators
Revenues:
Total revenues	23,995	1,609	37,481	53,415
Product Revenues, Net
Revenues:
Total revenues	$ 46,066	$ 460	$ 110,588	$ 460