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Stock-based Compensation - Stock Option Activity (Details) - USD ($)
$ / shares in Units, $ in Thousands
6 Months Ended 12 Months Ended
Jun. 30, 2018
Dec. 31, 2017
Number of Shares    
Beginning balance - Outstanding (shares) 3,075,994  
Granted (shares) 1,148,129  
Exercised (shares) 0  
Forfeited/Cancelled(shares) (147,708)  
Ending balance - Outstanding (shares) 4,076,415 3,075,994
Exercisable (shares) 1,958,226  
Vested or expected to vest (shares) 4,076,415  
Weighted- Average Exercise Price    
Beginning balance - Outstanding (in dollars per share) $ 5.59  
Granted (in dollars per share) 1.75  
Exercised (in dollars per share) 0  
Forfeited/Cancelled (in dollars per share) 7.63  
Ending balance - Outstanding (in dollars per share) 4.43 $ 5.59
Exercisable (in dollars per share) 6.27  
Vested or expected to vest (in dollars per share) $ 4.43  
Weighted- Average Remaining Contractual Life (in years)    
Balance - Outstanding 7 years 7 months 28 days 7 years 2 months 23 days
Exercisable 6 years 3 months 10 days  
Vested or expected to vest 7 years 7 months 28 days  
Aggregate Intrinsic Value ($000)    
Balance - Outstanding $ 12 $ 151
Exercisable 10  
Vested and expected to vest $ 12