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Stockholders' Equity - Additional Information (Detail) - USD ($)
1 Months Ended 12 Months Ended
Sep. 30, 2016
Jun. 21, 2016
Jul. 31, 2006
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
May 07, 2014
Equity [Abstract]              
Common stock, par value (in dollars per share)       $ 0.001 $ 0.001    
Common stock, shares authorized (in shares)       125,000,000 125,000,000    
Common stock, shares outstanding (in shares)       24,609,411 13,905,599 8,512,103  
Common stock, shares issued (in shares)       24,609,411 13,905,599    
Preferred shares authorized (in shares)       5,000,000 5,000,000   5,000,000
Preferred shares par value (in dollars per share)       $ 0.001 $ 0.001   $ 0.001
Preferred shares issued (in shares)       0 0    
Preferred shares outstanding (in shares)       0 0    
Schedule of Capitalization, Equity [Line Items]              
Number of warrants issued to purchase common stock (in shares)       14,033 14,033    
Change in fair value of derivative liability       $ 1,906,000 $ 0 $ 0  
Warrant liability       6,601,000 0    
Warrants Associated with Loan Agreement              
Schedule of Capitalization, Equity [Line Items]              
Number of warrants issued to purchase common stock (in shares) 122,435            
Exercise price of warrants (in dollars per share) $ 3.6754            
Warrants issued, expiration period (in years) 5 years            
June 2016 Public Offering              
Schedule of Capitalization, Equity [Line Items]              
Number of warrants issued to purchase common stock (in shares)   4,218,750          
Exercise price of warrants (in dollars per share)   $ 3.00          
Number of shares received per warrant (in shares)   0.45          
Warrants issued, expiration period (in years)   5 years          
Series C-1 Convertible Preferred Stock              
Schedule of Capitalization, Equity [Line Items]              
Number of warrants issued to purchase common stock (in shares)     196,923        
Exercise price of warrants (in dollars per share)     $ 3.25        
Fair value of warrant on issuance date     $ 459,000        
Derivative liability       $ 0 $ 0    
Common Stock              
Schedule of Capitalization, Equity [Line Items]              
Number of warrants issued to purchase common stock (in shares)     14,033        
Exercise price of warrants (in dollars per share)     $ 45.61