-----BEGIN PRIVACY-ENHANCED MESSAGE----- Proc-Type: 2001,MIC-CLEAR Originator-Name: webmaster@www.sec.gov Originator-Key-Asymmetric: MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB MIC-Info: RSA-MD5,RSA, NYZlq0sU0BFRkPHU3ecbSvbo6TlO4Cz9nD8yXhLBHehu3O4cm/Ow6jSlEM3n9Xfy iVadeAiW7tu/NykXHGPgfw== <SEC-DOCUMENT>0001165527-10-000845.txt : 20101112 <SEC-HEADER>0001165527-10-000845.hdr.sgml : 20101111 <ACCEPTANCE-DATETIME>20101112154935 ACCESSION NUMBER: 0001165527-10-000845 CONFORMED SUBMISSION TYPE: 10-Q/A PUBLIC DOCUMENT COUNT: 5 CONFORMED PERIOD OF REPORT: 20060331 FILED AS OF DATE: 20101112 DATE AS OF CHANGE: 20101112 FILER: COMPANY DATA: COMPANY CONFORMED NAME: UPSTREAM BIOSCIENCES INC. CENTRAL INDEX KEY: 0001174891 STANDARD INDUSTRIAL CLASSIFICATION: IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES [2835] IRS NUMBER: 000000000 FISCAL YEAR END: 1130 FILING VALUES: FORM TYPE: 10-Q/A SEC ACT: 1934 Act SEC FILE NUMBER: 000-50331 FILM NUMBER: 101186311 BUSINESS ADDRESS: STREET 1: 71130, 198-8060 SILVER SPRING BLVD. CITY: CALGARY STATE: A0 ZIP: T3B 5K2 BUSINESS PHONE: 403-537-2516 MAIL ADDRESS: STREET 1: 71130, 198-8060 SILVER SPRING BLVD. CITY: CALGARY STATE: A0 ZIP: T3B 5K2 FORMER COMPANY: FORMER CONFORMED NAME: FORCE ENERGY CORP. DATE OF NAME CHANGE: 20090415 FORMER COMPANY: FORMER CONFORMED NAME: UPSTREAM BIOSCIENCES INC. DATE OF NAME CHANGE: 20060209 FORMER COMPANY: FORMER CONFORMED NAME: INTEGRATED BRAND SOLUTIONS INC DATE OF NAME CHANGE: 20020605 </SEC-HEADER> <DOCUMENT> <TYPE>10-Q/A <SEQUENCE>1 <FILENAME>g4511.txt <DESCRIPTION>AMENDMENT NO. 2 TO FORM 10-Q <TEXT> UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 AMENDMENT NO. 2 TO FORM 10-QSB (Mark One) [X] QUARTERLY REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2006 [ ] TRANSITION REPORT UNDER SECTION 13 OR 15(d) OF THE EXCHANGE ACT For the transition period from __________ to __________ Commission file number 000-50331 UPSTREAM BIOSCIENCES INC. (Exact name of small business issuer as specified in its charter) Nevada 98-0371433 (State or other jurisdiction (IRS Employer of incorporation or organization) Identification No.) Suite 100 - 570 West 7th Avenue, Vancouver, British Columbia, Canada V5Z 4S6 (Address of principal executive offices) 604.707-5800 (Issuer's telephone number) 800 - 885 West Georgia Street, Vancouver, British Columbia, Canada V6C 3H1 (Former name, former address and former fiscal year, if changed since last report) Check whether the issuer (1) filed all reports required to be filed by Section 13 or 15(d) of the Exchange Act during the past 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes [X] No [ ] Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). (Check one): Yes [ ] No [X] APPLICABLE ONLY TO CORPORATE ISSUERS State the number of shares outstanding of each of the issuer's classes of common equity, as of the latest practicable date: 44,800,000 common shares issued and outstanding as of May 10, 2006 Transitional Small Business Disclosure Format (Check one): Yes [ ] No [X] <PAGE> EXPLANATION OF THE AMENDED FILING: THIS FORM 10-QSB AND THE CONSOLIDATED FINANCIAL STATEMENTS FOR THE THREE MONTHS ENDED MARCH 31, 2006 INCLUDED HEREIN HAVE BEEN AMENDED. OUR COMPANY HAS RESTATED THE FINANCIAL STATEMENTS TO CORRECT THE CALCULATION OF THE CONSOLIDATED ACCOUNTING FOR THE ACCRUAL SEVERANCE LIABILITIES TO TWO EMPLOYEES.. ACCORDINGLY, OUR COMPANY HAS RESTATED THE BALANCE SHEET, STATEMENT OF OPERATIONS AND DEFICIT, AND STATEMENT OF CASH FLOWS FOR THE PERIOD ENDING MARCH 31, 2006 TO CORRECTLY PRESENT THESE REVISED CALCULATIONS. 2 <PAGE> PART I - FINANCIAL INFORMATION ITEM 1. FINANCIAL STATEMENTS. Our financial statements are stated in United States dollars and are prepared in accordance with United States generally accepted accounting principles. It is the opinion of management that the consolidated interim financial statements for the quarter ended March 31, 2006 includes all adjustments necessary in order to ensure that the consolidated financial statements are not misleading. 3 <PAGE> UPSTREAM BIOSCIENCES INC. Vancouver, BC CONSOLIDATED FINANCIAL STATEMENTS For the Period Ended March 31, 2006 4 <PAGE> UPSTREAM BIOSCIENCES, INC. (A DEVELOPMENT STAGE COMPANY) CONSOLIDATED BALANCE SHEETS <TABLE> <CAPTION> March 31, 2006 (Unaudited) December 31, (Restated - 2005 see Note 8) (Audited) ---------- ---------- <S> <C> <C> ASSETS $ $ CURRENT ASSETS Cash 359,453 21,434 Receivables 301 1,286 Prepaid expenses 4,692 5,926 ---------- ---------- 364,446 28,646 ========== ========== LIABILITIES $ $ CURRENT LIABILITIES Accounts payable and accrued liabilities 69,640 8,089 Accrued license fees (Notes 7(a) and (b)) 23,706 23,706 Amounts owing to related parties 398,690 78,487 ---------- ---------- 492,036 110,282 CONVERTIBLE DEBENTURE (Note 4) 329,545 -- ---------- ---------- 821,581 110,282 ---------- ---------- COMMITMENTS AND CONTINGENCIES (Note 7) STOCKHOLDERS' DEFICIENCY COMMON STOCK (Note 5) 750,000,000 shares authorized at $0.001 par value 44,800,000 issued and outstanding (December 31, 2005 - 6,000,000) 845 345 ADDITIONAL PAID IN CAPITAL 1,014,614 -- DEFICIT ACCUMULATED DURING DEVELOPMENT STAGE (1,472,594) (81,981) ---------- ---------- (457,135) (81,636) ---------- ---------- 364,446 28,646 ========== ========== </TABLE> The accompanying notes are an integral part of these interim consolidated financial statements. 5 <PAGE> UPSTREAM BIOSCIENCES INC. (A DEVELOPMENT STAGE COMPANY) INTERIM CONSOLIDATED STATEMENTS OF OPERATIONS AND DEFICIT (UNAUDITED) <TABLE> <CAPTION> Cumulative From Inception (June 14, 2004) to For the Three Months Ended March 31, March 31, 2006 2006 (Restated - (Restated - see Note 8) 2005 see Note 8) ----------- ----------- ----------- <S> <C> <C> <C> $ $ $ REVENUE Consulting revenue -- 20,000 67,600 ----------- ----------- ----------- OPERATING EXPENSES Interest and bank charges 149,034 -- 149,266 Investor communications 6,281 -- 6,281 License fees and royalties 5,927 -- 22,948 Management compensation 377,429 36,806 480,060 Office and general administration 2,490 2,964 15,997 Professional fees 51,456 -- 67,646 Stock-based compensation to consultant 700,150 -- 700,150 ----------- ----------- ----------- 1,292,767 39,770 1,442,348 ----------- ----------- ----------- NET LOSS (1,292,767) (19,770) (1,374,748) DEFICIT, BEGINNING (81,981) 382 -- Reverse take over re-capitalization adjustment (Note 3) (97,846) -- (97,846) ----------- ----------- ----------- DEFICIT, ENDING (1,472,594) (19,388) (1,472,594) =========== =========== =========== BASIC NET LOSS PER SHARE (0.02) (0.003) =========== =========== WEIGHTED AVERAGE COMMON SHARES OUTSTANDING 64,164,835 6,000,000 =========== =========== </TABLE> The accompanying notes are an integral part of these interim consolidated financial statements 6 <PAGE> UPSTREAM BIOSCIENCES INC (A DEVELOPMENT STAGE COMPANY) INTERIM CONSOLIDATED STATEMENTS OF CASH FLOWS (UNAUDITED) <TABLE> <CAPTION> Cumulative From Inception (June 14, 2004) to For the Three Months Ended March 31, March 31, 2006 2006 (Restated - (Restated - see Note 8) 2005 see Note 8) ----------- ----------- ----------- <S> <C> <C> <C> $ $ $ CASH FLOW USED IN OPERATING ACTIVITIES Net loss (1,292,767) (19,770) (1,374,748) Non-cash items included in net loss: Stock based operating expenses 700,150 -- 700,150 Interest expense 144,509 -- 144,509 Accrued severance 300,000 -- 300,000 Changes in non-cash working capital: Receivables 985 14,330 (301) Prepaid expenses 1,234 -- (4,692) Accounts payable and accrued liabilities (36,295) 2,361 (28,206) Amounts owing to related parties 20,203 -- 98,690 Accrued license fees -- -- 23,706 ---------- ---------- ---------- NET CASH FLOW USED IN OPERATING ACTIVITIES (161,981) (3,079) (140,892) ---------- ---------- ---------- CASH FLOW FROM FINANCING ACTIVITIES Proceeds from convertible debentures 500,000 -- 500,000 Issuance of common stock for cash -- -- 345 Amounts owing to related parties -- 18,609 -- ---------- ---------- ---------- NET CASH FLOW FROM FINANCING ACTIVITIES 500,000 18,609 500,345 ---------- ---------- ---------- INCREASE IN CASH 338,019 15,530 359,453 CASH, BEGINNING 21,434 6,480 -- ---------- ---------- ---------- CASH, ENDING 359,453 22,010 359,453 ========== ========== ========== </TABLE> Supplemental disclosure with respect to cash flows (note 6) The accompanying notes are an integral part of these interim consolidated financial statements. 7 <PAGE> UPSTREAM BIOSCIENCES, INC (A DEVELOPMENT STAGE COMPANY) NOTES TO INTERIM CONSOLIDATED FINANCIAL STATEMENTS RESTATED MARCH 31, 2006 (UNAUDITED) (1) NATURE OF BUSINESS AND CONTINUANCE OF OPERATIONS By Share Exchange Agreement amended and dated February 24, 2006, Upstream Biosciences Inc. (formerly Integrated Brand Solutions Inc) (called "UBSI" or "the Company"), a Nevada corporation, incorporated on March 20, 2002 under the laws of the State of Nevada, acquired 100% of the issued and outstanding shares of Upstream Biosciences Inc. ("Upstream Canada"), in exchange for 24,000,000 shares of common stock of the Company representing 54.2% of the total issued and outstanding shares of the Company at the time (See Note 3). In connection with this transaction, UBSI changed its name to Upstream Biosciences Inc. This acquisition has been accounted for as a reverse acquisition with Upstream Canada being treated as the accounting parent (legal subsidiary) and UBSI being treated as the accounting subsidiary (legal parent). Accordingly, the consolidated results of operations of the Company include those of Upstream Canada for the period from its inception on June 14, 2004 and those of UBSI since the date of the reverse acquisition, February 24, 2006. Upstream Canada was incorporated on June 14, 2004 under the laws of Canada for the purpose of developing genetic diagnostic biomarkers for use in determining a patient's susceptibility to disease and predicting a patient's response to drugs. The business strategy is to generate revenues through licensing proprietary technologies or collaborating with third parties in the disease susceptibility, biomarkers identification, and drug response areas of cancer, primarily to companies that develop and/or market developing diagnostic products. The Company is currently considered a Development Stage Enterprise, under the guidelines of Statement of Financial Accounting Standards ("SFAS") No. 7. GOING CONCERN These consolidated financial statements have been prepared in accordance with United States generally accepted accounting principles, on a going concern basis, which contemplates the realization of assets and the satisfaction of liabilities and commitments in the normal course of business. As at March 31, 2006, the Company has a working capital deficiency of $127,590 and has incurred losses since inception of $1,472,594. Further losses are anticipated in the development of its business and there can be no assurance that the Company will be able to achieve or maintain profitability. The continuing operations of the Company and the recoverability of the carrying value of assets is dependent upon the ability of the Company to obtain necessary financing to fund its working capital requirements, and upon future profitable operations. The accompanying financial statements do not include any adjustments relative to the recoverability and classification of asset carrying amounts or the amount and classification of liabilities that might result from the outcome of this uncertainty. There can be no assurance that capital will be available as necessary to meet the Company's working capital requirements or, if the capital is available, that it will be on terms acceptable to the Company. The issuances of additional equity securities by the Company may result in dilution in the equity interests of its current stockholders. Obtaining commercial loans, assuming those loans would be available, will increase the Company's liabilities and future cash commitments. If the Company is unable to obtain financing in the amounts and on terms deemed acceptable, the business and future success may be adversely affected. 8 <PAGE> UPSTREAM BIOSCIENCES, INC (A DEVELOPMENT STAGE COMPANY) NOTES TO INTERIM CONSOLIDATED FINANCIAL STATEMENTS RESTATED MARCH 31, 2006 (UNAUDITED) BASIS OF PRESENTATION The unaudited interim consolidated financial statements included herein have been prepared in accordance with generally accepted accounting principles for interim financial information and with the instructions to Form 10-QSB and Item 310(b) of Regulation S-B. In the opinion of management, all adjustments (consisting of normal recurring accruals and stock transactions) considered necessary for a fair presentation have been included. Operating results for the restated three months ended March 31, 2006 are not necessarily indicative of the results that may be expected for any interim period or the entire year. For further information, these interim consolidated financial statements and the related notes should be read in conjunction with the Company's audited financial statements for the year ended December 31, 2005, included in the Company's annual report on Form 10-KSB. (2) SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (A) CONSOLIDATED FINANCIAL STATEMENTS The consolidated financial statements include the accounts of the Company and its wholly-owned subsidiary, Upstream Canada, which was acquired by reverse acquisition on February 24, 2006. All significant inter-company transactions and account balances have been eliminated. (B) CASH AND CASH EQUIVALENTS Cash equivalents consist of highly liquid investments that are readily convertible into cash with maturity of three months or less when purchased. As at March 31, 2006, the cash and cash equivalents consists of bank deposits. (C) FURNITURE AND EQUIPMENT Furniture and equipment is recorded at cost. Depreciation is computed to depreciate the cost of the furniture and equipment less residual values over its useful lives, estimated to be 4 years from date of acquisition. (D) DISPOSAL OF LONG-LIVED ASSETS In accordance with SFAS 144, "Accounting for the Impairment on Disposal of Long-Lived Assets" ("SFAS 144"), the Company measures all long-lived assets that are to be disposed of by sale at the lower of book value or fair value less disposal costs. As of March 31, 2006, management has determined that there are no material asset impairment obligations on disposal of long-lived assets. (E) FOREIGN CURRENCY TRANSACTIONS The functional currency of the Company is the US dollar and of Upstream Canada is the Canadian dollar. In accordance with SFAS No. 52, "Foreign Currency Translation", the foreign currency financial statements of Upstream Canada are re-measured into U.S. dollars. Monetary assets and liabilities are remeasured using the foreign exchange rate that prevailed at the balance sheet date. Revenue and expenses are translated at weighted average rates of exchange during the period and stockholders' equity accounts and capital asset accounts are translated by using historical exchange rates. The resulting re-measurement gain or loss is included in the consolidated statement of operations. (F) REVENUE RECOGNITION Revenue from all sources is recognized when the amount is fixed or determinable, delivery has occurred or initial services have been performed, and collection is reasonably assured. Any amounts received in advance of the goods being delivered or services being performed are recorded as deferred revenue. 9 <PAGE> UPSTREAM BIOSCIENCES, INC (A DEVELOPMENT STAGE COMPANY) NOTES TO INTERIM CONSOLIDATED FINANCIAL STATEMENTS RESTATED MARCH 31, 2006 (UNAUDITED) (G) GOVERNMENT ASSISTANCE The Company has received and may receive government assistance in the future regarding the research and development work of certain Company employees. When the work is performed, the related assistance amount is set up in receivables and credited to compensation expense. (H) INCOME TAXES The Company follows the liability method of accounting for income taxes. Under this method, deferred tax assets and liabilities are recognized for the deferred tax consequences attributable to differences between the financial statement carrying amounts of assets and liabilities and their respective tax balances. Deferred tax assets and liabilities are measured using enacted tax rates expected to apply to the taxable income in the years in which those differences are expected to be recovered or settled. The effect on deferred tax assets and liabilities of a change in tax rates is recognized in income in the period that includes the date of enactment. For deferred tax assets, the full amount of the potential future benefit is recorded. A valuation allowance is then used to adjust for the probability of realization. (I) FINANCIAL INSTRUMENTS In accordance with the requirements of SFAS No. 107, the Company has determined the estimated fair value of financial instruments using available market information and appropriate valuation methodologies. The fair value of financial instruments classified as current assets or liabilities (cash, receivables, accounts payable and advances from related parties) approximate carrying value due to the immediate or short-term maturity of these financial instruments. Fair values of long-term debt are based on market prices where available. When quoted market prices are not available, fair values are estimated using discounted cash flow analysis, based on the Company's current incremental borrowing rates for similar types of borrowing arrangements. (J) USE OF ESTIMATES The preparation of financial statements in conformity with accounting principles generally accepted in the United States of America requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of revenue and expenses during the reporting period. Actual results could differ from these estimates. Significant estimates used in preparing these financial statements are: (i) the capital transactions pertaining to the convertible debenture, including the fair value calculation of the detachable warrants and the embedded beneficial conversion feature; and (ii) the fair value of stock compensation expense. (K) STOCK-BASED COMPENSATION In December 2004, the Financial Accounting Standards Board ("FASB") issued SFAS No. 123R, "Share-Based Payment", which replaced SFAS No. 123, "Accounting for Stock-Based Compensation" and superseded APB Opinion No. 25, "Accounting for Stock Issued to Employees". In January 2005, the Securities and Exchange Commission ("SEC") issued Staff Accounting Bulletin ("SAB") No. 107, "Share-Based Payment", which provides supplemental implementation guidance for SFAS No. 123R. SFAS No. 123R requires all share-based payments to employees, including grants of employee stock options, to be recognized in the financial statements based on the grant date fair value of the award. SFAS No. 123R was to 10 <PAGE> UPSTREAM BIOSCIENCES, INC (A DEVELOPMENT STAGE COMPANY) NOTES TO INTERIM CONSOLIDATED FINANCIAL STATEMENTS RESTATED MARCH 31, 2006 (UNAUDITED) be effective for interim or annual reporting periods beginning on or after June 15, 2005, but in April 2005 the SEC issued a rule that will permit most registrants to implement SFAS No. 123R at the beginning of their next fiscal year, instead of the next reporting period as required by SFAS No. 123R. The pro-forma disclosures previously permitted under SFAS No. 123 no longer will be an alternative to financial statement recognition. Under SFAS No. 123R, the Company must determine the appropriate fair value model to be used for valuing share-based payments, the amortization method for compensation cost and the transition method to be used at date of adoption. The transition methods include prospective and retroactive adoption options. Under the retroactive options, prior periods may be restated either as of the beginning of the year of adoption or for all periods presented. The prospective method requires that compensation expense be recorded for all unvested stock options and restricted stock at the beginning of the first quarter of adoption of SFAS No. 123R, while the retroactive methods would record compensation expense for all unvested stock options and restricted stock beginning with the first period restated. The Company adopted the modified prospective approach of SFAS No. 123R for the fiscal year beginning on January 1, 2006. The Company recorded compensation expense in the first quarter of 2006 because there were vested stock options existing prior to the adoption. Stock-based compensation expense for awards granted prior to January 1, 2006 were based on the grant date fair-value as determined under the pro-forma provisions of SFAS No. 123. (L) EARNINGS (LOSS) PER SHARE The computation of basic earnings (loss) per share is computed by dividing net earnings (loss) available to common stockholders by the weighted average number of outstanding common shares of the company during the period. The diluted loss per share gives effect to all potentially dilutive common shares outstanding during the period. The computation of diluted loss per share does not assume conversion, exercise or contingent exercise of securities that would have an anti-dilutive effect on net loss. As of March 31, 2006, the Company had 600,000 potentially dilutive securities outstanding in the form of 200,000 share purchase warrants attached to the convertible debenture and 400,000 stock options granted. The accompanying presentation in the consolidated statements of operations only includes the basic net earnings (loss) per share since the potentially dilutive securities are anti-dilutive to the basic net earnings (loss) per share. (M) COMPARATIVE FIGURES Certain comparative figures have been reclassified to conform to the current period's presentation. (N) RECENT ACCOUNTING PRONOUNCEMENTS In February 2006, the FASB issued SFAS No. 155, "Accounting for Certain Hybrid Financial Instruments-an amendment of FASB Statements No. 133 and 140", to simplify and make more consistent the accounting for certain financial instruments. SFAS No. 155 amends SFAS No. 133, "Accounting for Derivative Instruments and Hedging Activities", to permit fair value re-measurement for any hybrid financial instrument with an embedded derivative that otherwise would require bifurcation, provided that the whole instrument is accounted for on a fair value basis. SFAS No. 155 amends SFAS No. 140, "Accounting for the Impairment or Disposal of Long-Lived Assets", to allow a qualifying special-purpose entity to hold a derivative financial instrument that pertains to a beneficial interest other than another derivative financial instrument. SFAS No. 155 applies to all financial instruments acquired or issued after the beginning of an entity's first fiscal year that begins after September 15, 2006, with earlier application allowed. This standard is not expected to have a significant effect on the Company's future reported financial position or results of operations. 11 <PAGE> UPSTREAM BIOSCIENCES, INC (A DEVELOPMENT STAGE COMPANY) NOTES TO INTERIM CONSOLIDATED FINANCIAL STATEMENTS RESTATED MARCH 31, 2006 (UNAUDITED) In March 2006, the FASB issued SFAS No. 156, "Accounting for Servicing of Financial Assets, an amendment of FASB Statement No. 140, Accounting for Transfers and Servicing of Financial Assets and Extinguishments of Liabilities". This statement requires all separately recognized servicing assets and servicing liabilities be initially measured at fair value, if practicable, and permits for subsequent measurement using either fair value measurement with changes in fair value reflected in earnings or the amortization and impairment requirements of Statement No. 140. The subsequent measurement of separately recognized servicing assets and servicing liabilities at fair value eliminates the necessity for entities that manage the risks inherent in servicing assets and servicing liabilities with derivatives to qualify for hedge accounting treatment and eliminates the characterization of declines in fair value as impairments or direct write-downs. SFAS No. 156 is effective for an entity's first fiscal year beginning after September 15, 2006. This standard is not expected to have a significant effect on the Company's future reported financial position or results of operations. (3) SHARE EXCHANGE AGREEMENT WITH UPSTREAMCANADA On February 24, 2006, the Company entered into an amended and restated share exchange agreement with Upstream Canada and the former shareholders of Upstream Canada. The amended share exchange agreement amended and restated the terms of a share exchange agreement initially dated February 3, 2006 that was entered into among the same parties. The closing of the transactions contemplated in the amended share exchange agreement and the acquisition of all of the issued and outstanding common stock of Upstream Canada occurred on March 1, 2006. In accordance with the closing of this agreement, the Company issued 24,000,000 common shares to the former shareholders of Upstream Canada in exchange for the acquisition by the Company of all 6,000,000 issued and outstanding common shares of Upstream Canada on the basis of four common shares of the company for every one common share of Upstream Canada. The Company had 44,300,000 common shares issued and outstanding as of March 1, 2006 after the issuance of the 24,000,000 common shares to former shareholders of Upstream Canada and the cancellation without consideration of 68,650,000 common shares held by two former significant shareholders of the Company. As of the closing date, the former shareholders of Upstream Canada held 24,000,000 common shares, representing approximately 54.2% of the issued and outstanding common shares of our company. The share exchange was deemed to be a reverse acquisition for accounting purposes whereby Upstream Canada is treated as the accounting parent (legal subsidiary) and UBSI is treated as the accounting subsidiary (legal parent). Upstream Canada, the acquired entity, is regarded as the predecessor entity as of March 1, 2006. 12 <PAGE> UPSTREAM BIOSCIENCES, INC (A DEVELOPMENT STAGE COMPANY) NOTES TO INTERIM CONSOLIDATED FINANCIAL STATEMENTS RESTATED MARCH 31, 2006 (UNAUDITED) (4) CONVERTIBLE DEBENTURE During the restated three months ended March 31, 2006, the Company issued a three year 5% $500,000 convertible debenture due on February 1, 2009. The debenture is convertible into 500,000 shares of common stock anytime at the Company's option. In addition, 200,000 share purchase warrants were issued to the debenture holder exercisable at $1.25 per share until the earlier of (a) December 31, 2006 or (b) when two patents have been filed with the US patent office claiming novel applications of the Company's technology to assist in the diagnosis of two diseases other than prostate cancer. The 5% interest is being accrued during the three year term of the debenture but is not payable until maturity. At restated March 31, 2006, accrued interest of $4,167 has been recorded. In accordance with EITF 98-5 "Accounting for Convertible Securities with Beneficial Conversion Features or Contingently Adjustable Conversion Ratios", the Company recognized the value of the embedded beneficial conversion feature of $134,482. This value was recorded immediately as non-cash interest expense for the three months ended March 31, 2006 since the debenture can be converted at any time. In addition and in accordance with EITF 00-27 "Application of Issue No. 98-5 to Certain Convertible Instruments", the Company has allocated the proceeds of issuance between the convertible debt and the detachable warrants based on their relative fair values. Accordingly, the Company recognized the fair value of the detachable warrants of $180,482 as additional paid-in capital and will record further interest expense over the term of the Convertible Debenture resulting from this difference between the stated value and carrying value at the date of issuance. As an offset, the carrying value of the Convertible Debenture will be accreted to the face value of $500,000 at maturity. In this connection, interest expense of $10,027 has been accreted for the restated three months ended March 31, 2006, increasing the carrying value of the Convertible Debenture from $319,516 at the date funds were received to $329,543 at March 31, 2006. (5) COMMON STOCK The authorized capital of the Company consists of 750,000,000 voting common shares with $0.001 par value. The combined changes in common stock and additional paid-in capital for the restated three months ended March 31, 2006 are as follows: <TABLE> <CAPTION> No. of Shares Amount ---------- ------ <S> <C> <C> $ Balance December 31, 2005 88,950,000 49,000 Shares issued in exchange for 100% of Upstream Canada shares 24,000,000 Shares of former Company shareholders cancelled as part of the acquisition (68,650,000) ----------- --------- Balance March 1, 2006 after share exchange 44,300,000 49,000 Shares issued as compensation to a consultant 500,000 600,000 Fair value of stock options granted 100,150 Capital transactions re. convertible debenture Fair value of detachable warrants 180,482 Embedded beneficial conversion feature 134,482 Par value of Upstream Canada shares issued 345 Consolidation elimination at date of acquisition (49,000) ----------- --------- Balance March 31, 2006 44,800,000 1,015,459 =========== ========= </TABLE> 13 <PAGE> UPSTREAM BIOSCIENCES, INC (A DEVELOPMENT STAGE COMPANY) NOTES TO INTERIM CONSOLIDATED FINANCIAL STATEMENTS RESTATED MARCH 31, 2006 (UNAUDITED) During the three months ended March 31, 2006: (i) the Company issued 24,000,000 shares of common stock to the former shareholders of Upstream Canada, representing 54.2% of the Company's outstanding shares at the closing date, in exchange for 100% of the shares of Upstream Canada. At the same time, 68,650,000 shares held by two former significant shareholders of the Company were cancelled without consideration. (See Note 3) (ii) the Company issued 500,000 shares of common stock and 400,000 stock options pursuant to a consulting agreement for financial and administrative services. The estimated fair values were $600,000 and $100,150 respectively, based on the Black-Scholes option pricing model, which amounts were recorded as compensation expense in the three months ended March 31, 2006. STOCK PURCHASE WARRANTS At March 31, 2006, the Company had 200,000 detachable warrants outstanding for the purchase of 200,000 common shares exercisable at $1.25 per share in connection with the convertible debenture described in Note 5. STOCK OPTIONS At March 31, 2006, the Company has granted 400,000 stock options to one Company officer exercisable until March 1, 2016 in accordance with the terms and conditions of a stock option plan currently under development, with 100,000 options vesting immediately and 300,000 options vesting at the rate of 100,000 per year over the following three years until February 2009. In addition, the Company has agreed to grant 800,000 stock options to two Company officers in the future under the terms and conditions of a stock option plan presently under development. Of this 800,000 stock options, 300,000 options will vest on February 28, 2007, 300,000 on February 28, 2008 and the balance of 200,000 on February 20, 2009. (6) SUPPLEMENTAL DISCLOSURE WITH RESPECT TO CASH FLOWS <TABLE> <CAPTION> Cumulative From Inception Six months ended Six months ended (June 14, 2004) to March 31, 2006 March 31, 2005 March 31, 2006 -------------- -------------- -------------- <S> <C> <C> <C> Cash paid during period for: Interest and bank charges $4,525 $ -- $4,757 Income taxes -- -- -- ====== ====== ====== </TABLE> 14 <PAGE> UPSTREAM BIOSCIENCES, INC (A DEVELOPMENT STAGE COMPANY) NOTES TO INTERIM CONSOLIDATED FINANCIAL STATEMENTS RESTATED MARCH 31, 2006 (UNAUDITED) A summary of the shares of common stock issued by the Company for non-cash consideration during the six months ended June 30, 2006 is presented below. During the restated three months ended March 31, 2006: (i) the Company issued 24,000,000 shares of common stock to the former shareholders of Upstream Canada, representing 54.2% of the Company's outstanding shares at the closing date, in exchange for 100% of the shares of Upstream Canada. At the same time, 68,650,000 shares held by two former significant shareholders of the Company were cancelled without consideration. (See Note 3) (ii) the Company issued 500,000 shares of common stock and 400,000 stock options pursuant to a consulting agreement for financial and administrative services. The estimated fair values were $600,000 and $100,150 respectively, based on the Black-Scholes option pricing model, which amounts were recorded as compensation expense in the three months ended March 31, 2006. (7) COMMITMENTS AND CONTINGENCIES (A) LICENSE AGREEMENT WITH THE UNIVERSITY OF BRITISH COLUMBIA Upstream Canada entered into a License Agreement with the University of British Columbia ("UBC") on March 23, 2005 for a term of ten years regarding bioinformatics technology developed at UBC. Under the contract, Upstream Canada agreed to pay a license fee consisting of $7,500 cash and an equity component yet to be determined. Due to the share exchange agreement with Upstream Canada described in Note 3, the Company is currently negotiating with the University of British Columbia to issue common shares of the Company instead of Upstream Canada shares in order to meet the equity portion of the license fee commitment. In addition to the license fee, Upstream Canada has agreed to pay minimum annual royalties commencing in March 2005 as follows: Years 1 and 2 $ 7,500 Years 3 through 7 15,000 Years 8 through 10 20,000 (B) LICENSE AGREEMENT WITH BRITISH COLUMBIA CANCER AGENCY BRANCH The Company entered into a License Agreement with the British Columbia Cancer Agency Branch ("BCCA") on March 10th, 2005 for a term of three years regarding Bioinformatics technology developed at UBC. Under the terms of the contract, the Company has agreed to pay a license fee of $20,000, payable in shares of the Company at a fair value which is subject to BCCA approval. In addition to the license fee, the Company has agreed to pay annual royalties equal to 10% of gross revenue from the sales of licensed product or $10,000, whichever is greater. (C) EMPLOYMENT CONTRACTS WITH COMPANY OFFICERS The Company has entered into employment contracts with three officers of the Company. The total annual compensation commitment is $300,000 with an additional $50,000 bonus payable to two of the officers pending the filing of US patents for DNA biomarkers for two additional diseases. 15 <PAGE> UPSTREAM BIOSCIENCES, INC (A DEVELOPMENT STAGE COMPANY) NOTES TO INTERIM CONSOLIDATED FINANCIAL STATEMENTS RESTATED MARCH 31, 2006 (UNAUDITED) (C) EMPLOYMENT CONTRACTS WITH COMPANY OFFICERS CONT'D After the first year anniversary of April 30, 2007, a 40% bonus will be payable to the two officers based on achieving the yet to be determined mutually agreed performance milestones. In addition and pursuant to these contracts: (i) 500,000 shares were issued as a signing bonus of which 300,000 shares were issued immediately and 200,000 shares were put into escrow pending achievement of specific performance; and (ii) 400,000 stock options were granted and 800,000 stock options were committed to be granted all in accordance with the terms and conditions of a stock option plan currently under development. In the event of contract termination and subject to a 90 day termination clause under two of the three contracts, retiring allowances of approximately $300,000 will become immediately payable to the three Company officers and have been expensed in the current reporting period. 8) RESTATEMENTS The Company has restated its financial statements for the three months ended March 31, 2006 to reflect the following adjustments: <TABLE> <CAPTION> As At March 31, 2006 ---------------------------------------------------------- As Originally Reported Adjustments As Restated -------- ----------- ----------- <S> <C> <C> <C> $ $ $ BALANCE SHEET Advances to related parties 98,690 300,000 398,690 Accumulated deficit (1,172,594) (300,000) (1,472,594) For The Three Months Ended March 31, 2006 ---------------------------------------------------------- As Originally Reported Adjustments As Restated -------- ----------- ----------- $ $ $ STATEMENT OF OPERATIONS AND DEFICIT Management compensation 77,429 300,000 377,429 Net Loss increase (992,767) (300,000) (1,292,767) STATEMENT OF CASH FLOWS Net cash flow (used in) operating activities (182,184) (320,203) (161,981) Net cash flow from financing activities 520,203 320,203 500,000 </TABLE> 16 <PAGE> UPSTREAM BIOSCIENCES, INC (A DEVELOPMENT STAGE COMPANY) NOTES TO INTERIM CONSOLIDATED FINANCIAL STATEMENTS RESTATED MARCH 31, 2006 (UNAUDITED) <TABLE> <CAPTION> Cumulative From Inception (June 14, 2004) to March 31, 2006 ------------------------------------------------------------ As Originally Reported Adjustments As Restated -------- ----------- ----------- <S> <C> <C> <C> $ $ $ STATEMENT OF OPERATIONS AND DEFICIT Management compensation 180,060 300,000 480,060 Net Loss increase (1,142,348) (300,000) (1,442,348) STATEMENT OF CASH FLOWS Net cash flow (used in) operating activities (239,582) (320,203) (140,892) Net cash flow from financing activities 599,035 (98,690) 500,345 </TABLE> (i) Employment Contract with Comp any Officers In connection with the employment contract with company officers, the Company has corrected the following: - The entire $300,000 of severance payable to officers and directors of the company has now been recognized in the March 31, 2006 reporting period rather than deferred over the life of the contracts as previously recorded. (ii) Other The net loss per share increased from $0.01 to $0.02 resulting from the restatement 17 <PAGE> ITEM 2. MANAGEMENT'S DISCUSSION AND ANALYSIS OR PLAN OF OPERATION. FORWARD-LOOKING STATEMENTS This quarterly report contains forward-looking statements as that term is defined in Section 27A of the United States Securities Act of 1933 and section 21E of the United States Securities Exchange Act of 1934. These statements relate to future events or our future financial performance. In some cases, you can identify forward-looking statements by terminology such as "may", "should", "expects", "plans", "anticipates", "believes", "estimates", "predicts", "potential" or "continue" or the negative of these terms or other comparable terminology. These statements are only predictions and involve known and unknown risks, uncertainties and other factors, including the risks in the section entitled "Risk Factors", that may cause our or our industry's actual results, levels of activity, performance or achievements to be materially different from any future results, levels of activity, performance or achievements expressed or implied by these forward-looking statements. Although we believe that the expectations reflected in the forward-looking statements are reasonable, we cannot guarantee future results, levels of activity, performance or achievements. Except as required by applicable law, including the securities laws of the United States, we do not intend to update any of the forward-looking statements to conform these statements to actual results. Our financial statements are stated in United States dollars and are prepared in conformity with generally accepted accounting principles in the United States of America for interim financial statements. The following discussion should be read in conjunction with our financial statements and the related notes that appear elsewhere in this quarterly report. As used in this quarterly report and unless otherwise indicated, the terms "we", "us" and "our" refer to Upstream Biosciences Inc., formerly known as Integrated Brand Solutions Inc., and our wholly-owned subsidiary. The term "Upstream Nevada" specifically refers to our company and the term "Upstream Canada" specifically refers to our wholly-owned subsidiary, Upstream Biosciences Inc., a Canadian corporation. Unless otherwise specified, all dollar amounts are expressed in United States dollars and all references to "common shares" refer to the common shares in our capital stock. CORPORATE HISTORY We were incorporated pursuant to the laws of the State of Nevada on March 20, 2002 under the name Integrated Brand Solutions Inc. On February 6, 2006, we changed our name to Upstream Biosciences Inc. after we entered into a share exchange agreement dated February 3, 2006 with Upstream Canada. The share exchange agreement contemplated our company acquiring all of the issued and outstanding common shares of Upstream Canada in exchange for the issuance by our company of 18,000,000 common shares. Following negotiations amongst the parties to the share exchange agreement, however, we entered into an amended and restated share exchange agreement dated February 24, 2006, whereby our company agreed to acquire all of the issued and outstanding stock of Upstream Canada in exchange for the issuance by our company of 24,000,000 common shares. The closing of the transactions contemplated in the amended share exchange agreement and the acquisition of all of the issued and outstanding shares of Upstream Canada occurred on March 1, 2006. As at the closing date, the former shareholders of Upstream Canada held approximately 54.2% of the issued and outstanding common shares of our company. The acquisition of Upstream Canada was deemed to be a reverse acquisition for accounting purposes. Upstream Canada, the acquired entity, is regarded as the predecessor entity as of March 1, 2006. Following our incorporation, we commenced the business as a start-up integrated marketing services company. We offered integrated marketing services such as advertising design, advertisement placement strategies, advertising sales, branding services, website development, marketing plans, and tools to establish focus groups and media strategies to prospective clients. Additionally, we offered advertising and integrated marketing and branding services in hopes of assisting companies in describing their products and services. We were not successful in implementing our business plan as a marketing and branding services business. As management of our company investigated opportunities and challenges in the business of being a marketing and branding 18 <PAGE> services company, management realized that the business did not present the best opportunity for our company to realize value for our shareholders. Accordingly, we abandoned our previous business plan and focussed on the identification of suitable businesses with which to enter into a business opportunity or business combination. SHARE EXCHANGE WITH UPSTREAM CANADA On February 24, 2006, we entered into an amended and restated share exchange agreement with Upstream Canada and the former shareholders of Upstream Canada. The amended share exchange agreement amended and restated the terms of a share exchange agreement dated February 3, 2006 that was entered into among the same parties. The closing of the transactions contemplated in the amended share exchange agreement and the acquisition of all of the issued and outstanding common stock of Upstream Canada occurred on March 1, 2006. In accordance with the closing of the amended share exchange agreement, we issued 24,000,000 common shares to the former shareholders of Upstream Canada in exchange for the acquisition by our company of all of the 6,000,000 issued and outstanding common shares of Upstream Canada on the basis of four common shares of our company for every one common share of Upstream Canada. Our company had 44,300,000 common shares issued and outstanding as of March 1, 2006 as a result of the issuance of 24,000,000 common shares to the former shareholders of Upstream Canada and the cancellation without consideration of 68,650,000 common shares held by two former significant shareholders of our company. As of the closing date, the former shareholders of Upstream Canada held 24,000,000 common shares, representing approximately 54.2% of the issued and outstanding common shares of our company. The share exchange was deemed to be a reverse acquisition for accounting purposes. Upstream Canada, the acquired entity, is regarded as the predecessor entity as of March 1, 2006. BUSINESS SUBSEQUENT TO THE ACQUISITION OF UPSTREAM CANADA As of the closing date of the amended share exchange agreement on March 1, 2006, our company commenced the business of developing genetic diagnostic biomarkers for use in determining a patient's susceptibility to disease and predicting a patient's response to drugs. Our business strategy is to generate revenues through licensing our technologies or collaborating with third parties in the disease susceptibility, biomarkers identification, and drug response areas of cancer, primarily to companies that develop and/or market developing diagnostic products. Our company focuses our research on variations in the untranslated regions of the human genome. Variations in these regions can be used as diagnostic markers to predict or aid in the prediction of susceptibility to disease or to predict a patient's response to drugs. We have identified and filed a provisional patent application on genetic markers that, following successful development and testing, may assist in determining the susceptibility of patients to liver cancer. These markers may also be important for determining the susceptibility of patients to other types of cancer, such as prostate or colorectal cancer. We have also filed a provisional patent application on an assay for identifying genetic markers that may predict a patient's response to a drug. On March 22, 2006, we have identified and filed a provisional patent application on genetic markers that, following successful development and testing, may assist in determining the susceptibility of patients to prostate cancer. We incorporate data, ideas and methods from disciplines such as mathematics, computer science, biochemistry, evolutionary biology, literature mining, pattern recognition and network analysis and apply such information in a manner that permits us to understand the genetic basis of human disease and the role that variations in genes and their related gene regulatory regions play in the onset of disease, particularly cancer. If successful, we believe that our research and development will result in predictive models, discovery engines and related technologies, which will enable us to develop potential diagnostic markers. The presence, absence, varying quantities, and varying composition of molecules provide information about the development of a disease or other physiological condition. A molecule that provides this information is referred to as a diagnostic marker. In order to develop a diagnostic marker, we must identify a correlation between the presence of a particular variation of a molecule and a disease or other physiological condition. Once a correlation is identified, we must develop a method for identifying the correlation. Our goal is to develop our research into marketable diagnostic markers that are easy to perform, sensitive, consistent, safe, inexpensive and cover an attractive market segment. 19 <PAGE> We are currently developing platforms and related technologies that we hope will enable the discovery of marketable diagnostic markers to aid in the disease susceptibility and drug response areas of cancer. We are currently developing our technologies which will enable us to identify and prioritize potential diagnostic markers. Our goal is to develop our platforms and related technologies to identify a variety of novel gene regulatory regions with potential applications in diagnostics. Our business strategy is to understand the relationship between genetic regulation, proteins and human diseases in order to develop molecular diagnostic products. Through our research and development, we intend to identify important disease genes, the proteins they produce, and the biological pathways in which they are involved to better understand the underlying molecular basis for the cause of human disease. We have not generated any revenues from our technologies to date, including the quarter ended March 31, 2006. We are a development stage company and we anticipate that we will require significant time and financing before our technologies are developed to a marketable state. Once we have developed our technologies to commercialization, we intend to generate revenues in one of two ways. We may elect to license our diagnostic biomarkers to third parties or we may elect to enter into joint ventures or other collaborations with third parties such as pharmaceutical, biotechnology and diagnostics companies, with the aim that they will develop and commercialize our discoveries into therapeutic or diagnostic products. If such a collaboration is successful, we will seek to receive payments upon the successful completion of certain predetermined developmental stages and milestones, and receive royalties from the sales of the drugs and/or diagnostics kits, which will be based on our discoveries. During the three months ended March 31, 2006, we did not generate any revenues from the licensing of our technologies. Our company had 44,800,000 common shares issued and outstanding as of March 31, 2006 PLAN OF OPERATIONS As of March 31, 2006, our company had cash and cash equivalents of $359,453 and working capital deficiency of $127,590. We estimate our operating expenses and working capital requirements for the next twelve month period to be as follows: Estimated Expenses for the Next Twelve Month Period Operating Expenses Employee and Consultant Compensation $480,000 Business Development and Travel Expenses $194,000 Professional Fees $170,000 Royalties $ 50,000 General and Administrative Expenses $ 40,000 -------- Total $934,000 ======== PRODUCT RESEARCH AND DEVELOPMENT Except for approximately $15,000 that we may spend in connection with the development of our website, we do not anticipate that we will expend any significant additional funds on research and development, other than the salaries of Joel Bellenson, our Chief Executive Officer, and Dexster Smith, our President, over the next twelve month period. PURCHASE OF SIGNIFICANT EQUIPMENT We do not intend to purchase any significant equipment over the twelve months period. EMPLOYEES As of May 10, 2006, we had four employees consisting of Joel Bellenson as our Chief Executive Officer, Dexster Smith as our President, Tim Fernback as our Chief Financial Officer and Steve Bajic as our Secretary and Treasurer. We plan to hire additional employees when circumstances warrant. 20 <PAGE> EMPLOYEE AND CONSULTANT COMPENSATION We estimate that our employee and consultant compensation expenses for the next twelve month period will be approximately $480,000. Most of our employee and consultant compensation expense consists of research and development costs of our technology by Joel Bellenson, our Chief Executive Officer, and Dexster Smith, our President. All of our current research and development is carried out by Mr. Bellenson and Mr. Smith. Both individuals have entered into employment agreements with our company. Pursuant to the terms of the employment agreements, our company agreed to pay Mr. Bellenson and Mr. Smith a base salary of $85,000. Upon our company's filing of a provisional patent application on the application of our DNA biomarkers to enhance the accuracy of existing prostrate cancer diagnostic tests, our company increased their respective salaries to $120,000. Our company is also required to increase the respective salaries to $150,000 if our company files provisional patent applications for DNA biomarkers for two additional diseases. In addition to options that are anticipated to be issued to Mr. Bellenson and Mr. Smith, our company has also agreed to pay a bonus of $25,000 upon the filing of a provisional patent application on the same terms set out above. This bonus was paid to Mr. Bellenson and Mr. Smith on March 31, 2006, in conjunction with reaching this provisional patent application milestone. Our company has also agreed to pay a further bonus of $25,000 upon the filing of provisional patent applications for DNA biomarkers for two additional diseases. Our company has also retained TCF Ventures Corp., a company beneficially owned by Mr. Tim Fernback, as a consultant to provide financial advisory services to our company pursuant to the terms of a Consultant Engagement Agreement dated February 7, 2006, as amended on February 13, 2006. In addition to the issuance of common shares and options as set out in the agreement, our company has agreed to pay the consultant $4,510 (CDN$5,000) per month plus applicable taxes subject to adjustment as set out in the consulting agreement. Upon reaching the first milestone as described in the consulting agreement on March 31, 2006, our company has agreed to pay the consultant approximately $5,410 (CDN$6,000) per month plus applicable taxes subject to further adjustment as set out in the consulting agreement. On April 12, 2006, Mr. Fernback became our company's Chief Financial Officer. Although our company anticipates that the majority of our research and development requirements will be met from the efforts of Mr. Bellenson and Mr. Smith, we may retain additional services as and when circumstances warrant. In the event we require such services, we intend to hire such persons as independent contractors based upon terms to be determined when needed. BUSINESS DEVELOPMENT AND TRAVEL EXPENSES We estimate our business development and travel expenses for the next twelve month period to be the approximately $194,000. We anticipate that will incur $94,000 in investor relations and marketing costs and $100,000 in travel costs and attending industry conferences. We have hired an investor relations person to, among other things, produce investor and marketing materials. Our company also intends to incur traveling expenses to attend biotech related conferences and investigate additional financing opportunities should our company require additional financing during the next twelve month period. PROFESSIONAL FEES We expect to incur significant legal expenses to prepare and file a number of provisional patent applications over the next twelve month period, as new discoveries are made in our research and development process. Furthermore, as a publicly traded company, we expect the incur on-going legal and accounting expenses to comply with our reporting responsibilities as public company under the United States Securities Exchange Act of 1934, as amended. During the next twelve month period, we intend to obtain director and officer insurance and perhaps general insurance for our company. We estimate our legal, accounting and insurance expenses for the next fiscal year to be approximately $170,000. 21 <PAGE> ROYALTIES We estimate our royalty related expenditures on licensing complementary technology for the next twelve month period to be in the aggregate amount of $50,000. GENERAL AND ADMINISTRATIVE EXPENSES We anticipate spending $40,000 on general and administrative costs in the next twelve month period. These costs primarily consist of expenses such as rent, office supplies and office equipment. TRENDS AND UNCERTAINTIES Our ability to generate revenues in the future is dependent on whether we successfully develop our technologies and create a marketable product and license or otherwise commercialize our products. We cannot predict whether or when this may happen and this causes uncertainty with respect to the growth of our company and our ability to generate revenues. FINANCING To date, we have had negative cash flows from operations and we have been dependent on sales of our equity securities and debt financing to meet our cash requirements. We expect this situation to continue for the foreseeable future. We anticipate that we will have negative cash flows in the next twelve month period. Our company incurred a loss of $1,292,767 for the three months ended March 31, 2006. The majority of this loss was a direct result of incurring a stock compensation expense of $700,150. As of March 31, 2006, we had working a capital deficiency of $127,590. On March 1, 2006, effective February 1, 2006, we issued a 5% $1,000,000 convertible debenture and 400,000 warrants to purchase shares of our common stock. Each warrant entitles the holder to purchase one share of our common stock for an exercise price of $1.25 per share. The terms of the convertible debenture are set out in Item 1.01 of our Current Report on Form 8-K filed on March 7, 2006. As indicated above, our estimated working capital requirements and projected operating expenses for the next twelve month period total $934,000. As we had cash of $359,453 and current assets of $364,446 as at March 31, 2006, we anticipate that such funds will not be sufficient to pay our estimated expenses for the next twelve month period. We intend to fulfill any additional cash requirement through the sale of our equity securities. There are no assurances that we will be able to obtain funds required for our continued operation. There can be no assurance that additional financing will be available to us when needed or, if available, that it can be obtained on commercially reasonable terms. If we are not able to obtain additional financing on a timely basis, we will not be able to meet our other obligations as they become due and we will be forced to scale down or perhaps even cease the operation of our business. Given that we are a development stage company and have not generated significant revenues to date, our cash flow projections are subject to numerous contingencies and risk factors beyond our control, including market acceptance of our products, competition from well-funded competitors, and our ability to manage our expected growth. We can offer no assurance that our company will generate cash flow sufficient to meet our cash flow projections or that our expenses will not exceed our projections. If our expenses exceed estimates, we will require additional monies during the next twelve months to execute our business plan. There is substantial doubt about our ability to continue as a going concern as the continuation of our business is dependent upon obtaining further long-term financing, successful development of our technologies into a marketable product and successful and sufficient market acceptance of our products once developed and, finally, achieving a profitable level of operations. The issuance of additional equity securities by us could result in a significant dilution in the equity interests of our current stockholders. Obtaining commercial loans, assuming those loans would be available, will increase our liabilities and future cash commitments. 22 <PAGE> LIQUIDITY AND CAPITAL RESOURCES As of March 31, 2006, we had cash and cash equivalents of $359,453 and $492,036 in current liabilities. The current liabilities primarily consisted of accrued license fees of $23,706, amounts due to shareholders in the amount of $398,690 and accounts payable and accrued liabilities of $69,640. We had a working capital deficiency of $127,590 as of March 31, 2006. During the three months ended March 31, 2006, our company issued a 5% $1,000,000 convertible debenture on March 1, 2006, effective as of February 1, 2006 to Novar Capital Corp. The terms of the convertible debenture are set out in Item 1.01 of our Current Report on Form 8-K filed on March 7, 2006. There are no assurances that we will be able to obtain further funds required for our continued operations. We intend to pursue various financing alternatives to meet our immediate and long-term financial requirements. There can be no assurance that additional financing will be available to us when needed or, if available, that it can be obtained on commercially reasonable terms. If we are not able to obtain additional financing on a timely basis, we will be unable to conduct our operations as planned, and we will not be able to meet our other obligations as they become due. In such event, we will be forced to scale down or perhaps even cease our operations. GOING CONCERN Due to the uncertainty of our ability to meet our current operating and capital expenses, in their report on Upstream Canada's audited financial statements for the year ended December 31, 2005, Upstream Canada's independent auditors included an explanatory paragraph regarding substantial doubt about its ability to continue as a going concern. Our financial statements contain additional note disclosures describing the circumstances that lead to this disclosure by our independent auditors. Our March 31, 2006 financial statements also reflect an explanatory paragraph regarding substantial doubt about our ability to continue as a going concern. OFF-BALANCE SHEET ARRANGEMENTS Our company has no outstanding derivative financial instruments, off-balance sheet guarantees, interest rate swap transactions or foreign currency contracts. Neither our company nor our operating subsidiary engages in trading activities involving non-exchange traded contracts. CAPITAL EXPENDITURES We incurred a negligible amount of capital expenditures during the three months ended March 31, 2006 and 2005. As of May 10, 2006, our company did not have any material commitments for capital expenditures and management does not anticipate that our company will spend additional material amounts on capital expenditures in the next twelve month period. CRITICAL ACCOUNTING POLICIES The preparation of financial statements in conformity with United States generally accepted accounting principles requires management to make estimates and assumptions that affect the amounts reported in the financial statements and accompanying disclosures of our company. Although these estimates are based on management's knowledge of current events and actions that our company may undertake in the future, actual results may differ from such estimates. DEFERRED INCOME TAX We use the liability method in accounting for income taxes. Under this method, our future tax assets and liabilities are determined based on differences between the financial reporting and tax bases of assets and liabilities and unutilized non-capital assets, and measured using the substantially enacted rates and laws that are in effect when the differences are expected to reverse. Future tax expense was based on the benefits of tax losses that was reported in different years in the financial statements and tax returns and measured at the 23 <PAGE> tax rate in effect in the year the difference originated. The carrying in value of future income tax assets is limited to the amount that is more likely than not to be realized. RISK FACTORS Much of the information included in this current report includes or is based upon estimates, projections or other "forward-looking statements". Such forward-looking statements include any projections or estimates made by us and our management in connection with our business operations. While these forward-looking statements, and any assumptions upon which they are based, are made in good faith and reflect our current judgment regarding the direction of our business, actual results will almost always vary, sometimes materially, from any estimates, predictions, projections, assumptions or other future performance suggested herein. Such estimates, projections or other "forward-looking statements" involve various risks and uncertainties as outlined below. We caution the reader that important factors in some cases have affected and, in the future, could materially affect actual results and cause actual results to differ materially from the results expressed in any such estimates, projections or other "forward-looking statements". Our common shares are considered speculative during the development of our new business operations. Prospective investors should consider carefully the risk factors set out below. RISKS RELATED TO OUR BUSINESS WE HAVE HAD NEGATIVE CASH FLOWS FROM OPERATIONS SINCE INCEPTION. WE WILL REQUIRE SIGNIFICANT ADDITIONAL FINANCING, THE AVAILABILITY OF WHICH CANNOT BE ASSURED, AND IF OUR COMPANY IS UNABLE TO OBTAIN SUCH FINANCING, OUR BUSINESS MAY FAIL. To date, we have had negative cash flows from operations and have depended on sales of our equity securities and debt financing to meet our cash requirements. Our ability to develop and, if warranted, commercialize our technologies, will be dependent upon our ability to raise significant additional financing. If we are unable to obtain such financing, we will not be able to fully develop our business. Specifically, we will need to raise additional funds to: - support our planned growth and carry out our business plan; - continue scientific progress in our research and development programs; - address costs and timing of conducting clinical trials and seek regulatory approvals and patent prosecutions; - address competing technological and market developments; - establish additional collaborative relationships; and - market and develop our technologies. We may not be able to obtain additional equity or debt financing on acceptable terms as required. Even if financing is available, it may not be available on terms that are favorable to us or in sufficient amounts to satisfy our requirements. If we require, but are unable to obtain, additional financing in the future, we may be unable to implement our business plan and our growth strategies, respond to changing business or economic conditions, withstand adverse operating results and compete effectively. More importantly, if we are unable to raise further financing when required, we may be forced to scale down our operations and our ability to generate revenues may be negatively affected. WE HAVE A HISTORY OF LOSSES AND NOMINAL OPERATING RESULTS, WHICH RAISE SUBSTANTIAL DOUBT ABOUT OUR ABILITY TO CONTINUE AS A GOING CONCERN. 24 <PAGE> Since inception through March 31, 2006, we have incurred aggregate net losses of $1,472,594 from operations. We can offer no assurance that we will operate profitably or that we will generate positive cash flow in the future. In addition, our operating results in the future may be subject to significant fluctuations due to many factors not within our control, such as the level of competition and general economic conditions. Our company's operations will be subject to all the risks inherent in the establishment of a developing enterprise and the uncertainties arising from the absence of a significant operating history. No assurance can be given that we may be able to operate on a profitable basis. Due to the nature of our business and the early stage of our development, our securities must be considered highly speculative. We are engaged in the business of developing and commercializing genetic biomarkers, which technology is in the development stage and we have not commenced the regulatory approval process for our technology. We have not realized a profit from our operations to date and there is little likelihood that we will realize any profits in the short or medium term. Any profitability in the future from our business will be dependent upon the successful commercialization or licensing of our core technology, which itself is subject to numerous risk factors as set forth herein. We expect to continue to incur development costs and operating costs. Consequently, we expect to incur operating losses and negative cash flows until our technology gains market acceptance sufficient to generate a sustainable level of income from the commercialization or licensing of our technology. Our history of losses and nominal operating results raise substantial doubt about our ability to continue as a going concern, as described in the explanatory paragraph in Upstream Canada's independent registered public accounting firm's report dated February 14, 2006, as well as in the notes to our March 31, 2006 quarterly financial statements. WE HOLD NO PATENTS ON OUR PROPRIETARY TECHNOLOGY AND IF WE ARE NOT ABLE TO PROTECT OUR PROPRIETARY TECHNOLOGY, OUR COMPANY WILL SUFFER A MATERIAL ADVERSE EFFECT. We currently have three provisional patent applications of our technologies. We currently rely on the provisional patent applications and trade secrets to protect our proprietary intellectual property. The departure of any of our management or any significant technical personnel or consultants we hire in the future, the breach of their confidentiality and non-disclosure obligations, or the failure to achieve our intellectual property objectives may have a material adverse effect on our business, financial condition and results of operations. We believe our success depends upon the knowledge and experience of our management and our ability to market our existing technology and to develop new technologies. While we believe that we have adequately protected our proprietary technology, and we intend to take all appropriate and reasonable legal measures to protect it in the future, the use of our technology by a competitor could have a material adverse effect on our business, financial condition and results of operations. Our ability to compete successfully and achieve future revenue growth will depend, in part, on our ability to protect our proprietary technology and operate without infringing upon the rights of others. We may not be able to successfully protect our proprietary technology, and our proprietary technology may otherwise become known or similar technology may be independently developed by competitors. Competitors may discover novel uses, develop similar or more marketable technologies or offer services similar to our company at lower prices. We cannot predict whether our technologies and services will compete successfully with the technologies and services of existing or emerging competitors. OUR INABILITY TO COMPLETE OUR PRODUCT DEVELOPMENT ACTIVITIES SUCCESSFULLY MAY SEVERELY LIMIT OUR ABILITY TO OPERATE AND FINANCE OPERATIONS. Commercialization of our core technology will require significant additional research and development as well as substantial clinical trials. We believe that the United States will be the principal market for our technology, although we may elect to expand into Japan and Western Europe. We may not be able to successfully complete development of our core technology, or successfully market our technology. We, and any of our potential collaborators, may encounter problems and delays relating to research and development, regulatory approval and intellectual property rights of our technology. Our research and development programs may not be successful. Our core technology may not prove to be safe and efficacious in clinical trials, and we may not obtain the intended regulatory approvals for our core technology. Whether or not any of these events occur, we 25 <PAGE> may not have adequate resources to continue operations for the period required to resolve the issue delaying commercialization and we may not be able to raise capital to finance our continued operation during the period required for resolution of that issue. WE MAY LOSE OUR COMPETITIVENESS IF WE ARE NOT ABLE TO PROTECT OUR PROPRIETARY TECHNOLOGY AND INTELLECTUAL PROPERTY RIGHTS AGAINST INFRINGEMENT, AND ANY RELATED LITIGATION MAY BE TIME-CONSUMING AND COSTLY. Our success and ability to compete depends to a significant degree on our proprietary technology. If any of our competitors copy or otherwise gain access to our proprietary technology or develop similar technologies independently, we may not be able to compete as effectively. The measures we have implemented to protect our proprietary technology and other intellectual property rights are currently based upon a combination of provisional patent applications and trade secrets. This, however, may not be adequate to prevent the unauthorized use of our proprietary technology and our other intellectual property rights. Further, the laws of foreign countries may provide inadequate protection of such intellectual property rights. We may need to bring legal claims to enforce or protect such intellectual property rights. Any litigation, whether successful or unsuccessful, may result in substantial costs and a diversion of our company's resources. In addition, notwithstanding our rights to our intellectual property, other persons may bring claims against us alleging that we have infringed on their intellectual property rights or claims that our intellectual property rights are not valid. Any claims against us, with or without merit, could be time consuming and costly to defend or litigate, divert our attention and resources, result in the loss of goodwill associated with our business or require us to make changes to our technology. IF OUR PROVISIONAL PATENT APPLICATIONS AND PROPRIETARY RIGHTS DO NOT PROVIDE SUBSTANTIAL PROTECTION, THEN OUR BUSINESS AND COMPETITIVE POSITION WILL SUFFER. Our success depends in large part on our ability to develop, commercialize and protect our proprietary technology. However, patents may not be granted on any of our provisional or future patent applications. Also, the scope of any future patent may not be sufficiently broad to offer meaningful protection. In addition, any patents granted to us in the future may be successfully challenged, invalidated or circumvented so that such patent rights may not create an effective competitive barrier. OUR COMPANY MAY BECOME SUBJECT TO INTELLECTUAL PROPERTY LITIGATION WHICH MAY HARM OUR BUSINESS. Our success depends in part on our ability to develop commercially viable products without infringing the proprietary rights of others. Although we have not been subject to any filed infringement claims, other patents could exist or could be filed which may prohibit or limit our ability to market our products or maintain a competitive position. In the event of an intellectual property dispute, we may be forced to litigate. Intellectual property litigation may divert management's attention from developing our technology and may force us to incur substantial costs regardless of whether we are successful. An adverse outcome could subject us to significant liabilities to third parties, and force us to curtail or cease the development and commercialization of our technology. IF OUR COMPANY COMMERCIALIZES OR TESTS OUR TECHNOLOGY, OUR COMPANY WILL BE SUBJECT TO POTENTIAL PRODUCT LIABILITY CLAIMS WHICH MAY AFFECT OUR EARNINGS AND FINANCIAL CONDITION. We face an inherent business risk of exposure to product liability claims in the event that the use of our core technology during research and development efforts, including clinical trials, or after commercialization, results in adverse affects. As a result, we may incur significant product liability exposure, which may exceed any insurance coverage that we obtain in the future. Even if we elect to purchase such issuance in the future, we may not be able to maintain adequate levels of insurance at reasonable cost and/or reasonable terms. Excessive insurance costs or uninsured claims may increase our operating loss and affect our financial condition. WE HAVE NOT GENERATED ANY REVENUES FROM OPERATIONS AND IF WE ARE UNABLE TO DEVELOP MARKET SHARE AND GENERATE SIGNIFICANT REVENUES FROM THE COMMERCIALIZATION OR LICENSING OF OUR TECHNOLOGY, THEN OUR BUSINESS MAY FAIL. We operate in a highly competitive industry and our failure to compete effectively and generate income through the commercialization or licensing of our technology may adversely affect our ability to generate revenue. The business of developing genetic biomarkers is highly competitive and subject to frequent technological innovation with improved price and/or performance characteristics. There can be no assurance that our new or existing technologies will gain market acceptance. Management is aware of similar technologies which 26 <PAGE> our technology, when developed to a stage of commercialization, will compete directly against. Many of our competitors have greater financial, technical, sales and marketing resources, better name recognition and a larger customer base than ours. In addition, many of our large competitors may offer customers a broader or superior range of services and technologies. Some of our competitors may conduct more extensive promotional activities and offer lower commercialization and licensing costs to customers than we do, which could allow them to gain greater market share or prevent us from establishing and increasing our market share. Increased competition in the genetic biomarker industry may result in significant price competition, reduced profit margins or loss of market share, any of which may have a material adverse effect on our ability to generate revenues and successfully operate our business. Our competitors may develop technologies superior to those that our company is currently developing. In the future, we may need to decrease our prices if our competitors lower their prices. Our competitors may be able to respond more quickly to new or changing opportunities, technologies and customer requirements. Such competition will potentially affect our chances of achieving profitability, and ultimately affect our ability to continue as a going concern. RAPID TECHNOLOGICAL CHANGES IN OUR INDUSTRY MAY RENDER OUR TECHNOLOGY NON-COMPETITIVE OR OBSOLETE AND CONSEQUENTLY AFFECT OUR ABILITY TO GENERATE FUTURE REVENUES. The genetic biomarker industry is characterized by rapidly changing technology, evolving industry standards and varying customer demand. We believe that our success will depend on our ability to generate income through the commercialization and licensing of our technology and that it will require us to continuously develop and enhance our technology that is currently being developed and introduce new and more technologically advanced technologies promptly into the market. We can make no assurance that our technology will not become obsolete due to the introduction of alternative technologies. If we are unable to continue to develop and introduce new genetic biomarkers to meet technological changes and changes in market demands, our business and operating results, including our ability to generate revenues, may be adversely affected. IF WE FAIL TO EFFECTIVELY MANAGE THE GROWTH OF OUR COMPANY AND THE COMMERCIALIZATION OR LICENSING OF OUR TECHNOLOGY, OUR FUTURE BUSINESS RESULTS COULD BE HARMED AND OUR MANAGERIAL AND OPERATIONAL RESOURCES MAY BE STRAINED. As we proceed with the development of our technology and the expansion of our marketing and commercialization efforts, we expect to experience significant growth in the scope and complexity of our business. We will need to add staff to market our services, manage operations, handle sales and marketing efforts and perform finance and accounting functions. We anticipate that we will be required to hire a broad range of additional personnel in order to successfully advance our operations. This growth is likely to place a strain on our management and operational resources. The failure to develop and implement effective systems, or to hire and retain sufficient personnel for the performance of all of the functions necessary to effectively service and manage our potential business, or the failure to manage growth effectively, could have a material adverse effect on our business and financial condition. FAILURE TO OBTAIN AND MAINTAIN REQUIRED REGULATORY APPROVALS WILL SEVERELY LIMIT OUR ABILITY TO COMMERCIALIZE OUR TECHNOLOGY. We believe that it is important for the success of our business to obtain the approval of the Food and Drug Administration in the United States (FDA) before we commence commercialization of our technology in the United States, the principal market for our technology. We may also be required to obtain additional approvals from foreign regulatory authorities to apply for any sales activities we may carry out in those jurisdictions. If we cannot demonstrate the safety, reliability and efficacy of our technology, the FDA or other regulatory authorities could delay or withhold regulatory approval of our technology. Even if we obtain regulatory approval of our technology, that approval may be subject to limitations on the indicated uses for which it may be marketed. Even after granting regulatory approval, the FDA and other regulatory agencies and governments in other countries will continue to review and inspect any future marketed products as well as any manufacturing facilities that we may establish in the future. Later discovery of previously unknown problems with a product or facility may result in restrictions on the product, including a withdrawal of the product from the market. Further, governmental regulatory agencies may establish additional regulations which could prevent or delay regulatory approval of our technology. 27 <PAGE> EVEN IF WE OBTAIN REGULATORY APPROVAL TO COMMERCIALIZE OUR TECHNOLOGY, LACK OF COMMERCIAL ACCEPTANCE MAY IMPAIR OUR BUSINESS. Our product development efforts are primarily directed toward obtaining regulatory approval to market genetic diagnostic markers. Diagnostic markers for cancer have been widely available for a number of years, and our technology may not be accepted by the marketplace as readily as these or other competing products, processes and methodologies. Additionally, our technology may not be employed in all potential applications being investigated, and any reduction in applications may limit the market acceptance of our technology and our potential revenues. As a result, even if our technology is developed into a marketable technology and we obtain all required regulatory approvals, we cannot be certain that our technology will be adopted at a level that would allow us to operate profitably. IF WE DO NOT KEEP PACE WITH OUR COMPETITORS, TECHNOLOGICAL ADVANCEMENTS AND MARKET CHANGES, OUR TECHNOLOGY MAY BECOME OBSOLETE AND OUR BUSINESS MAY SUFFER. The market for our technology is very competitive, is subject to rapid technological changes and varies for different individual products. We believe that there are potentially many competitive approaches being pursued that compete with our technology, including some by private companies for which information is difficult to obtain. Many of our competitors have significantly greater resources and have developed products and processes that directly compete with our technology. Our competitors may develop, or may in the future develop, new technologies that directly compete with our technology or even render our technology obsolete. Our technology is designed to develop diagnostic products. Even if we are able to demonstrate improved or equivalent results from our technology, researchers and practitioners may not use our technology and we may suffer a competitive disadvantage. Finally, to the extent that others develop new technologies that address the targeted application for our current technology, our business will suffer. OUR ABILITY TO HIRE AND RETAIN KEY PERSONNEL WILL BE AN IMPORTANT FACTOR IN THE SUCCESS OF OUR BUSINESS AND A FAILURE TO HIRE AND RETAIN KEY PERSONNEL MAY RESULT IN OUR INABILITY TO MANAGE AND IMPLEMENT OUR BUSINESS PLAN. We are highly dependent upon our management personnel such Joel Bellenson and Dexster Smith because of their experience developing genetic diagnostic markers. The loss of the services of one or more of these individuals may impair management's ability to operate our company. We have not purchased key man insurance on any of these individuals, which insurance would provide us with insurance proceeds in the event of their death. Without key man insurance, we may not have the financial resources to develop or maintain our business until we could replace the individual or to replace any business lost by the death of that person. The competition for qualified personnel in the markets in which we operate is intense. In addition, in order to manage growth effectively, we must implement management systems and recruit and train new employees. We may not be able to attract and retain the necessary qualified personnel. If we are unable to retain or to hire qualified personnel as required, we may not be able to adequately manage and implement our business. WE WILL DEPEND UPON THE ESTABLISHMENT OF RELATIONSHIPS WITH THIRD PARTIES TO TEST OUR TECHNOLOGIES AND ANY RELATIONSHIP MAY REQUIRE OUR COMPANY TO SHARE REVENUES AND TECHNOLOGY. Management anticipates that it will be crucial to identify the degree of elevated or reduced risk of a particular disease or medication based on a particular variation or combination of variations. To do so will require access to samples of patients who have had the diseases in question as well as normal populations. And for each of these collections of samples, it will be important to note the demographic and epidemiological ranges covered by the collection. This would entail establishing relationships with clinics, hospitals, universities and companies that have repositories of biological samples with carefully curated patient disease and demographic information. These relationships have various confidentiality provisions that require negotiations that can span several months. In addition, some of these institutions have national or provincial mandates for providing access to these samples that may require us to make our test results publicly available for these jurisdictions or institutions at a reduced rate and could also require us to provide a flow back of intellectual property licensing for their further research process. Any such requirement may reduce our revenues. 28 <PAGE> OUR COMPANY WILL BE DEPENDENT ON VARIOUS OUTSOURCING ACTIVITIES FOR TESTING OUR TECHNOLOGY AND FAILURE TO OUTSOURCE CERTAIN ACTIVITIES WILL HAVE A MATERIAL ADVERSE EFFECT ON OUR COMPANY. We intend to establish relationships with various vendors of biological laboratory services. Such laboratory services may include DNA SNP profiling, gene expression profiling, cell culturing, recombinant techniques for inserting reporter genes into artificial constructs for testing purposes, profiling of transcription factors active in different disease states, and other laboratory and analytical services depending upon the outcome of the results at various stages. Our ability to secure and maintain these future relationships will be critical to the success of our business objectives, and conversely the inability to secure these future relationships on reasonable commercial terms represents a risk and could have a material adverse effect on our operations or financial condition. MOST OF OUR ASSETS AND ALL OF OUR DIRECTORS AND OFFICERS ARE OUTSIDE THE UNITED STATES, WITH THE RESULT THAT IT MAY BE DIFFICULT FOR INVESTORS TO ENFORCE WITHIN THE UNITED STATES ANY JUDGMENTS OBTAINED AGAINST US OR ANY OF OUR DIRECTORS OR OFFICERS. Although we are organized under the laws of the State of Nevada, United States, our principal business office is located in Vancouver, British Columbia, Canada. Outside the United States, it may be difficult for investors to enforce judgements against us that are obtained in the United States in any action, including actions predicated upon civil liability provisions of federal securities laws. In addition, all of our directors and officers reside outside the United States, and nearly all of the assets of these persons and our assets are located outside of the United States. As a result, it may not be possible for investors to effect service of process within the United States upon such persons or to enforce against us or such persons judgements predicated upon the liability provisions of United States securities laws. There is substantial doubt as to the enforceability against us or any of our directors and officers located outside the United States in original actions or in actions of enforcement of judgments of United States courts or liabilities predicated on the civil liability provisions of United States federal securities laws. In addition, as the majority of our assets are located outside of the United States, it may be difficult to enforce United States bankruptcy proceedings against us. Under bankruptcy laws in the United States, courts typically have jurisdiction over a debtor's property, wherever it is located, including property situated in other countries. Courts outside of the United States may not recognize the United States bankruptcy court's jurisdiction. Accordingly, you may have trouble administering a United States bankruptcy case involving a Nevada company as debtor with most of its property located outside the United States. Any orders or judgements of a bankruptcy court obtained by you in the United States may not be enforceable. OUR BUSINESS IS SUBJECT TO COMPREHENSIVE GOVERNMENT REGULATION AND ANY CHANGE IN SUCH REGULATION MAY HAVE A MATERIAL ADVERSE EFFECT ON OUR COMPANY. There is no assurance that the laws, regulations, policies or current administrative practices of any government body, organization or regulatory agency in the United States or any other jurisdiction, will not be changed, applied or interpreted in a manner which will fundamentally alter the ability of our company to carry on our business. The actions, policies or regulations, or changes thereto, of any government body or regulatory agency, or other special interest groups, may have a detrimental effect on our company. Any or all of these situations may have a negative impact on our operations. RISKS RELATED TO OUR COMMON STOCK A DECLINE IN THE PRICE OF OUR COMMON STOCK COULD AFFECT OUR ABILITY TO RAISE FURTHER WORKING CAPITAL AND ADVERSELY IMPACT OUR ABILITY TO CONTINUE OPERATIONS. A prolonged decline in the price of our common stock could result in a reduction in the liquidity of our common stock and a reduction in our ability to raise capital. Because a significant portion of our operations has been and will be financed through the sale of equity securities, a decline in the price of our common stock could be especially detrimental to our liquidity and our operations. Such reductions may force us to reallocate funds from other planned uses and may have a significant negative effect on our business plans and operations, including our ability to develop new products and continue our current operations. If our stock price declines, we can offer no assurance that we will be able to raise additional capital or generate funds from operations sufficient to meet our obligations. If we are unable to raise sufficient capital in the future, we may not be able to have the resources to continue our normal operations. 29 <PAGE> The market price for our common stock may also be affected by our ability to meet or exceed expectations of analysts or investors. Any failure to meet these expectations, even if minor, may have a material adverse effect on the market price of our common stock. IF WE ISSUE ADDITIONAL SHARES IN THE FUTURE, IT WILL RESULT IN THE DILUTION OF OUR EXISTING SHAREHOLDERS. Our certificate of incorporation authorizes the issuance of up to 750,000,000 shares of common stock. Our board of directors may choose to issue some or all of such shares to acquire one or more businesses or to provide additional financing in the future. The issuance of any such shares will result in a reduction of the book value and market price of the outstanding shares of our common stock. If we issue any such additional shares, such issuance will cause a reduction in the proportionate ownership and voting power of all current shareholders. Further, such issuance may result in a change of control of our corporation. TRADING OF OUR STOCK MAY BE RESTRICTED BY THE SECURITIES EXCHANGE COMMISSION'S PENNY STOCK REGULATIONS, WHICH MAY LIMIT A STOCKHOLDER'S ABILITY TO BUY AND SELL OUR STOCK. The Securities and Exchange Commission has adopted regulations which generally define "penny stock" to be any equity security that has a market price (as defined) less than $5.00 per share or an exercise price of less than $5.00 per share, subject to certain exceptions. Our securities are covered by the penny stock rules, which impose additional sales practice requirements on broker-dealers who sell to persons other than established customers and "accredited investors". The term "accredited investor" refers generally to institutions with assets in excess of $5,000,000 or individuals with a net worth in excess of $1,000,000 or annual income exceeding $200,000 or $300,000 jointly with their spouse. The penny stock rules require a broker-dealer, prior to a transaction in a penny stock not otherwise exempt from the rules, to deliver a standardized risk disclosure document in a form prepared by the Securities and Exchange Commission, which provides information about penny stocks and the nature and level of risks in the penny stock market. The broker-dealer also must provide the customer with current bid and offer quotations for the penny stock, the compensation of the broker-dealer and its salesperson in the transaction and monthly account statements showing the market value of each penny stock held in the customer's account. The bid and offer quotations, and the broker-dealer and salesperson compensation information, must be given to the customer orally or in writing prior to effecting the transaction and must be given to the customer in writing before or with the customer's confirmation. In addition, the penny stock rules require that prior to a transaction in a penny stock not otherwise exempt from these rules, the broker-dealer must make a special written determination that the penny stock is a suitable investment for the purchaser and receive the purchaser's written agreement to the transaction. These disclosure requirements may have the effect of reducing the level of trading activity in the secondary market for the stock that is subject to these penny stock rules. Consequently, these penny stock rules may affect the ability of broker-dealers to trade our securities. We believe that the penny stock rules discourage investor interest in and limit the marketability of our common stock. NASD SALES PRACTICE REQUIREMENTS MAY ALSO LIMIT A STOCKHOLDER'S ABILITY TO BUY AND SELL OUR STOCK. In addition to the "penny stock" rules described above, the National Association of Securities Dealers (NASD) has adopted rules that require that in recommending an investment to a customer, a broker-dealer must have reasonable grounds for believing that the investment is suitable for that customer. Prior to recommending speculative low priced securities to their non-institutional customers, broker-dealers must make reasonable efforts to obtain information about the customer's financial status, tax status, investment objectives and other information. Under interpretations of these rules, the NASD believes that there is a high probability that speculative low priced securities will not be suitable for at least some customers. The NASD requirements make it more difficult for broker-dealers to recommend that their customers buy our common stock, which may limit your ability to buy and sell our stock and have an adverse effect on the market for our shares. OUR COMMON STOCK IS ILLIQUID AND THE PRICE OF OUR COMMON STOCK MAY BE NEGATIVELY IMPACTED BY FACTORS WHICH ARE UNRELATED TO OUR OPERATIONS. Our common stock currently trades on a limited basis on the OTC Bulletin Board. Trading of our stock through the OTC Bulletin Board is frequently thin and highly volatile. There is no assurance that a sufficient market will develop in the stock, in which case it could be difficult for shareholders to sell their stock. The market price of our common stock could fluctuate substantially due to 30 <PAGE> a variety of factors, including market perception of our ability to achieve our planned growth, quarterly operating results of our competitors, trading volume in our common stock, changes in general conditions in the economy and the financial markets or other developments affecting our competitors or us. In addition, the stock market is subject to extreme price and volume fluctuations. This volatility has had a significant effect on the market price of securities issued by many companies for reasons unrelated to their operating performance and could have the same effect on our common stock. ITEM 4. CONTROLS AND PROCEDURES. As required by Rule 13a-15 under the Securities Exchange Act of 1934, as of the end of the period covered by this quarterly report, being March 31, 2006, we have carried out an evaluation of the effectiveness of the design and operation of our company's disclosure controls and procedures. This evaluation was carried out under the supervision and with the participation of our company's management, including our company's Chief Executive Officer and our Chief Financial Officer. Based upon that evaluation, our company's Chief Executive Officer and our Chief Financial Officer concluded that our company's disclosure controls and procedures are effective as at the end of the period covered by this report On July 7, 2006, and following the filing of the original Form 10-QSB on May 15, 2006, our board of directors authorized the termination of our previous independent auditor, HLB Cinnamon Jang Willoughby, Chartered Accountants and authorized the appointment of Dale Matheson Carr-Hilton Labonte, Chartered Accountants ("DMCL"), as independent auditor of our company. Our company is of the opinion that DMCL is duly qualified for auditing our financial statements on a going forward basis. In addition to the appointment of DMCL, we appointed a chartered accountant with AYL Enterprises Ltd. to provide additional accounting services to our company in late July 2006. Other than the termination and subsequent appointment of a new independent auditor, and the addition of the accounting services of AYL Enterprises Ltd., there has been no changes in our company's internal controls or in other factors, which could affect internal control subsequent to the date we carried out our evaluation. Disclosure controls and procedures and other procedures that are designed to ensure that information required to be disclosed in our reports filed or submitted under the Securities Exchange Act of 1934 is recorded, processed, summarized and reported, within the time period specified in the Securities and Exchange Commission's rules and forms. Disclosure controls and procedures include, without limitation, controls and procedures designed to ensure that information required to be disclosed in our reports filed under the Securities Exchange Act of 1934 is accumulated and communicated to management including our Chief Executive Officer and our Chief Financial Officer as appropriate, to allow timely decisions regarding required disclosure. PART II - OTHER INFORMATION ITEM 1. LEGAL PROCEEDINGS. We know of no material, active or pending legal proceedings against us, nor are we involved as a plaintiff in any material proceedings or pending litigation. There are no proceedings in which any of our directors, officers or affiliates, or any registered beneficial shareholder are an adverse party or has a material interest adverse to us. ITEM 2. UNREGISTERED SALES OF EQUITY SECURITIES AND USE OF PROCEEDS. On February 13, 2006, we granted stock options to a consultant for the option to purchase an aggregate of 400,000 shares of our common stock at an exercise price of $0.80 per share, exercisable until March 1, 2016. The options are subject to vesting provisions as set forth in the stock option and subscription agreement dated February 13, 2006. We issued the securities to a non U.S. person (as that term is defined in Regulation S of the Securities Act of 1933) in an offshore transaction relying on Regulation S and/or Section 4(2) of the Securities Act of 1933. On April 12, 2006, and subsequent to the end of the quarter ended March 31, 2006, our company appointed the consultant as our Chief Financial Officer. 31 <PAGE> In connection with the closing of the amended and restated share exchange agreement on March 1, 2006, our company issued 24,000,000 shares of our common stock to the two former shareholders of Upstream Canada. The shares were issued to the two former shareholders of Upstream Canada, who were not U.S. Persons (as that term is defined in Regulation S under the Securities Act of 1933), in an offshore transaction relying on Regulation S and/or Section 4(2) of the Securities Act of 1933. Additionally, in connection with the closing of the amended and restated share exchange agreement on March 1, 2006, effective February 1, 2006, our company issued a 5% $1,000,000 convertible debenture and 400,000 warrants. Each warrant entitles the holder to purchase one share of our common stock for an exercise price of $1.25 per share. The terms of the convertible debenture are set out in Item 1.01 of our Current Report on Form 8-K filed on March 7, 2006. Our company received $500,000 of the debenture proceeds following the closing of the share exchange agreement and received the remaining $500,000 on April 4, 2006, subsequent to the quarter ended March 31, 2006. The convertible debenture and the warrants were issued (and the issuance of common shares upon the conversion of the convertible debenture and the exercise of the warrants will be issued) in reliance upon an exemption from registration in an offering of securities in an offshore transaction to a non U.S. Person (as that term is defined in Regulation S of the Securities Act of 1933), relying on Regulation S and/or Section 4(2) of the Securities Act of 1933. On March 17, 2006, we issued 500,000 shares of common stock to a consultant of our company pursuant to a consultant engagement agreement. The shares were issued in consideration for the consultant providing financial services to our company. We issued the shares in an offshore transaction to the consultant as a non-U.S. person (as that term is defined in Regulation S under the Securities Act of 1933) relying on Section 4(2) or Regulation S promulgated under the Securities Act of 1933. On April 12, 2006, and subsequent to the end of the quarter ended March 31, 2006, our company appointed the consultant as our Chief Financial Officer. ITEM 3. DEFAULTS UPON SENIOR SECURITIES. None. ITEM 4. SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS. None. ITEM 5. OTHER INFORMATION. None. ITEM 6. EXHIBITS. Exhibits required by Item 601 of Regulation S-B Exhibit Number Description - ------ ----------- (2) PLAN OF PURCHASE, SALE, REORGANIZATION, ARRANGEMENT, LIQUIDATION OR SUCCESSION 2.1 Share Exchange Agreement dated February 3, 2006, among our company, Upstream Canada, the shareholders of Upstream Canada and Steve Bajic (incorporated by reference from our Current Report on Form 8-K filed on February 6, 2006). 2.2 Amended and Restated Share Exchange Agreement dated February 24, 2006, among our company, Upstream Canada, the shareholders of Upstream Canada and Steve Bajic (incorporated by reference from our Current Report on Form 8-K filed on February 27, 2006). (3) ARTICLES OF INCORPORATION AND BY-LAWS 3.1 Articles of Incorporation (incorporated by reference from our Registration Statement on Form SB-2 filed on July 5, 2002). 32 <PAGE> 3.2 Bylaws (incorporated by reference from our Registration Statement on Form SB-2 Filed on July 5, 2002). 3.3 Certificate of Amendment filed with the Nevada Secretary of State on March 8, 2005 (incorporated by reference from our Current Report on Form 8-K filed on March 10, 2005). 3.4 Certificate of Change filed with the Nevada Secretary of State on December 20, 2005 (incorporated by reference from our Current Report on Form 8-K filed on December 29, 2005). 3.5 Articles of Merger filed with the Nevada Secretary of State on February 6, 2006 (incorporated by reference from our Current Report on Form 8-K filed on February 9, 2006). (10) MATERIAL CONTRACTS 10.1 Master Consulting Services Agreements dated August 6, 2004, between Upstream Canada and Kinexus Bioinformatics Corporation (incorporated by reference from our Current Report on Form 8-K filed on March 7, 2006). 10.2 Collaborative Research Agreement dated August 11, 2004, among Upstream Canada, the University of British Columbia and Vancouver Coastal Health Authority (incorporated by reference from our Current Report on Form 8-K filed on March 7, 2006). 10.3 Contract Service Agreement dated December 20, 2004, between Inimex Pharmaceuticals Inc. and Upstream Canada (incorporated by reference from our Current Report on Form 8-K filed on March 7, 2006). 10.4 License Agreement dated March 10, 2005, between British Columbia Cancer Agency Branch and Upstream Canada (incorporated by reference from our Current Report on Form 8-K filed on March 7, 2006). 10.5 License Agreement dated March 23, 2005, between The University of British Columbia and Upstream Canada (incorporated by reference from our Current Report on Form 8-K filed on March 7, 2006). 10.6 Letter Agreement dated July 17, 2005 between Integrated Brand Solutions Inc. and ABS Capital Finance (incorporated by reference from our Current Report on Form 8-K filed on July 21, 2005). 10.7 Termination Agreement dated September 19, 2005 between Integrated Brand Solutions Inc. and ABS Capital Finance Inc. (incorporated by reference from our Current Report on Form 8-K filed on September 27, 2005). 10.8 5% $1,000,000 Convertible Debenture dated February 1, 2006 issued to Novar Capital Corp. by our company (incorporated by reference from our Current Report on Form 8-K filed on March 7, 2006). 10.9 Consultant Engagement Agreement dated February 7, 2006 among TCF Ventures Corp., our company and Upstream Canada (incorporated by reference from our Current Report on Form 8-K filed on March 7, 2006). 10.10 Stock Option and Subscription Agreement dated February 13, 2006, between our company and TCF Ventures Corp. (incorporated by reference from our Current Report on Form 8-K filed on March 7, 2006). 10.11 Amendment Agreement dated February 13, 2006, among TCF Ventures Corp., our company and Upstream Canada (incorporated by reference from our Current Report on Form 8-K filed on March 7, 2006). 10.12 Assignment of Invention Agreement dated February 27, 2006 among Joel Bellenson, Dexster Smith and our company (incorporated by reference from our Current Report on Form 8-K filed on March 7, 2006). 33 <PAGE> 10.13 Assignment of Invention Agreement dated February 27, 2006 among Joel Bellenson, Dexster Smith and our company (incorporated by reference from our Current Report on Form 8-K filed on March 7, 2006). 10.14 Employment Agreement dated March 1, 2006, between our company and Joel Bellenson (incorporated by reference from our Current Report on Form 8-K filed on March 7, 2006). 10.15 Employment Agreement dated March 1, 2006 between our company and Dexster Smith (incorporated by reference from our Current Report on Form 8-K filed on March 7, 2006). (31) SECTION 302 CERTIFICATIONS 31.1* Section 302 Certification. 31.2* Section 302 Certification. (32) SECTION 906 CERTIFICATIONS 32.1* Section 906 Certification. 32.2* Section 906 Certification. - ---------- * Filed herewith 34 <PAGE> SIGNATURES In accordance with the requirements of the Exchange Act, the registrant caused this report to be signed on its behalf by the undersigned, thereunto duly authorized. UPSTREAM BIOSCIENCES INC. By: /s/ Joel Bellenson - ---------------------------------------------------- Joel Bellenson, Chief Executive Officer and Director (Principal Executive Officer) November 10, 2010 /s/ Tim Fernback - ---------------------------------------------------- Tim Fernback, Chief Financial Officer (Principal Financial Officer and Accounting Officer) November 10, 2010 35 </TEXT> </DOCUMENT> <DOCUMENT> <TYPE>EX-31.1 <SEQUENCE>2 <FILENAME>ex31-1.txt <DESCRIPTION>CEO SECTION 302 CERTIFICATION <TEXT> Exhibit 31.1 CERTIFICATION I, Joel Bellenson, certify that: 1. I have reviewed this report on Form 10-Q/A of Upstream Biosciences Inc.; 2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report; 3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report; 4. I am responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have: a) Designed such disclosure controls and procedures or caused such disclosure controls and procedures to be designed under my supervision, to ensure that material information relating to the registrant is made known to me particularly during the period in which this report is being prepared; b) Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under my supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles; c) Evaluated the effectiveness of the registrant's disclosure controls and procedures and presented in this report my conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and d) Disclosed in this report any change in the registrant's internal control over financial reporting that occurred during the registrant's most recent fiscal quarter (the registrant's fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant's internal control over financial reporting; and 5. I have disclosed, based on my most recent evaluation of internal control over financial reporting, to the registrant's auditors and the audit committee of registrant's board of directors (or persons performing the equivalent functions): a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant's ability to record, process, summarize and report financial information; and b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant's internal control over financial reporting. Date: November 10, 2010 /s/ Joel Bellenson - ---------------------------------------------------- Joel Bellenson, Chief Executive Officer and Director (Principal Executive Officer) </TEXT> </DOCUMENT> <DOCUMENT> <TYPE>EX-31.2 <SEQUENCE>3 <FILENAME>ex31-2.txt <DESCRIPTION>CFO SECTION 302 CERTIFICATION <TEXT> Exhibit 31.2 CERTIFICATION I, Tim Fernback, certify that: 1. I have reviewed this report on Form 10-Q/A of Upstream Biosciences Inc.; 2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report; 3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report; 4. I am responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have: a) Designed such disclosure controls and procedures or caused such disclosure controls and procedures to be designed under my supervision, to ensure that material information relating to the registrant is made known to me particularly during the period in which this report is being prepared; b) Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under my supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles; c) Evaluated the effectiveness of the registrant's disclosure controls and procedures and presented in this report my conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and d) Disclosed in this report any change in the registrant's internal control over financial reporting that occurred during the registrant's most recent fiscal quarter (the registrant's fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant's internal control over financial reporting; and 5. I have disclosed, based on my most recent evaluation of internal control over financial reporting, to the registrant's auditors and the audit committee of registrant's board of directors (or persons performing the equivalent functions): a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant's ability to record, process, summarize and report financial information; and b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant's internal control over financial reporting. Date: November 10, 2010 /s/ Tim Fernback - ---------------------------------------------------- Tim Fernback, Chief Financial Officer (Principal Financial Officer and Accounting Officer) </TEXT> </DOCUMENT> <DOCUMENT> <TYPE>EX-32.1 <SEQUENCE>4 <FILENAME>ex32-1.txt <DESCRIPTION>CEO SECTION 906 CERTIFICATION <TEXT> Exhibit 32.1 CERTIFICATION OF CHIEF EXECUTIVE OFFICER PURSUANT TO 18 U.S.C. SECTION 1350, AS ADOPTED PURSUANT TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002 In connection with the Quarterly Report of Upstream Biosciences Inc. (the "Company") on Form 10-Q/A for the period ending March 31, 2006 as filed with the Securities and Exchange Commission on the date hereof (the "Report"), I, Joel Bellenson, Chief Executive Officer of the Company, certify, pursuant to 18 U.S.C. ss.1350, as adopted pursuant to ss.906 of the Sarbanes-Oxley Act of 2002, that: (1) The Report fully complies with the requirements of section 13(a) or 15(d) of the Securities Exchange Act of 1934; and (2) The information contained in the Report fairly presents, in all material respects, the financial condition and result of operations of the Company. IN WITNESS WHEREOF, the undersigned has executed this certification as of the 10th day of November, 2010. /s/ Joel Bellenson - ---------------------------------------------------- Joel Bellenson, Chief Executive Officer and Director (Principal Executive Officer) </TEXT> </DOCUMENT> <DOCUMENT> <TYPE>EX-32.2 <SEQUENCE>5 <FILENAME>ex32-2.txt <DESCRIPTION>CFO SECTION 906 CERTIFICATION <TEXT> Exhibit 32.2 CERTIFICATION OF CHIEF FINANCIAL OFFICER PURSUANT TO 18 U.S.C. SECTION 1350, AS ADOPTED PURSUANT TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002 In connection with the Quarterly Report of Upstream Biosciences Inc. (the "Company") on Form 10-Q/A for the period ending March 31, 2006 as filed with the Securities and Exchange Commission on the date hereof (the "Report"), I, Tim Fernback, Chief Financial Officer of the Company, certify, pursuant to 18 U.S.C. ss.1350, as adopted pursuant to ss.906 of the Sarbanes-Oxley Act of 2002, that: (1) The Report fully complies with the requirements of section 13(a) or 15(d) of the Securities Exchange Act of 1934; and (2) The information contained in the Report fairly presents, in all material respects, the financial condition and result of operations of the Company. IN WITNESS WHEREOF, the undersigned has executed this certification as of the 10th day of November, 2010. /s/ Tim Fernback - ---------------------------------------------------- Tim Fernback, Chief Financial Officer (Principal Financial Officer and Accounting Officer) </TEXT> </DOCUMENT> </SEC-DOCUMENT> -----END PRIVACY-ENHANCED MESSAGE-----