-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 Fw8nORQWEVvUNuFX2uNeciP18vnHmttaXidEYCyQKOhCerzjfRAKsFV45eNz64jh
 I39po7TO/a8omAWp7ZTlMA==

<SEC-DOCUMENT>0001225208-10-020110.txt : 20100901
<SEC-HEADER>0001225208-10-020110.hdr.sgml : 20100901
<ACCEPTANCE-DATETIME>20100901143110
ACCESSION NUMBER:		0001225208-10-020110
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20100831
FILED AS OF DATE:		20100901
DATE AS OF CHANGE:		20100901

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			KLEPPER KENNETH O
		CENTRAL INDEX KEY:			0001203666

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-31312
		FILM NUMBER:		101052256

	MAIL ADDRESS:	
		STREET 1:		MEDCO HEALTH SOLUTIONS, INC.
		STREET 2:		100 PARSONS POND DRIVE
		CITY:			FRANKLIN LAKES
		STATE:			NJ
		ZIP:			07417

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			MEDCO HEALTH SOLUTIONS INC
		CENTRAL INDEX KEY:			0001170650
		STANDARD INDUSTRIAL CLASSIFICATION:	RETAIL-DRUG STORES AND PROPRIETARY STORES [5912]
		IRS NUMBER:				223461740
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1226

	BUSINESS ADDRESS:	
		STREET 1:		100 PARSONS POND DR
		CITY:			FRANKLIN LAKES
		STATE:			NJ
		ZIP:			07417
		BUSINESS PHONE:		2012693400

	MAIL ADDRESS:	
		STREET 1:		100 PARSONS POND DR
		CITY:			FRANKLIN LAKES
		STATE:			NJ
		ZIP:			07417

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	MEDCOHEALTH SOLUTIONS INC
		DATE OF NAME CHANGE:	20020528

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	MERCK MEDCO MANAGED CARE LLC
		DATE OF NAME CHANGE:	20020404
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>doc4.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0303</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2010-08-31</periodOfReport>

    <issuer>
        <issuerCik>0001170650</issuerCik>
        <issuerName>MEDCO HEALTH SOLUTIONS INC</issuerName>
        <issuerTradingSymbol>MHS</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001203666</rptOwnerCik>
            <rptOwnerName>KLEPPER KENNETH O</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>100 PARSONS POND DRIVE</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>FRANKLIN LAKES</rptOwnerCity>
            <rptOwnerState>NJ</rptOwnerState>
            <rptOwnerZipCode>07417</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isOfficer>1</isOfficer>
            <officerTitle>President-Chief Oper. Officer</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2010-08-31</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>F</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>3106.0000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>43.4800</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>214439.0000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes></footnotes>

    <ownerSignature>
        <signatureName>Colleen M. McIntosh, Attorney in Fact</signatureName>
        <signatureDate>2010-09-01</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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