Deferred Sublicense Revenue (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021	Dec. 31, 2021
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Cumulative Sublicense Revenue Recognized	$ 208	$ 10,338	$ 325	$ 10,338
Less current portion of long-term deferred sublicense revenue	(1,400)		(1,400)		$ (1,547)
Total long-term deferred sublicense revenue	7,443		7,443		$ 7,622
Alfasigma S.p.A.
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Transaction Price			20,000
Cumulative Sublicense Revenue Recognized			11,157
Deferred Sublicense Revenue	8,843		8,843
Less current portion of long-term deferred sublicense revenue	(1,400)		(1,400)
Total long-term deferred sublicense revenue	7,443		7,443
License | Alfasigma S.p.A.
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Transaction Price			10,223
Cumulative Sublicense Revenue Recognized			10,223
Deferred Sublicense Revenue	0		0
Development and Regulatory Services | Alfasigma S.p.A.
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Transaction Price			2,647
Cumulative Sublicense Revenue Recognized			934
Deferred Sublicense Revenue	1,713		1,713
Supply of License Product | Alfasigma S.p.A.
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Transaction Price			7,130
Cumulative Sublicense Revenue Recognized			0
Deferred Sublicense Revenue	$ 7,130		$ 7,130