Deferred Sublicense Revenue (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021	Dec. 31, 2021
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Cumulative Sublicense Revenue Recognized	$ 117	$ 0
Less current portion of long-term deferred sublicense revenue	(1,594)		$ (1,547)
Total long-term deferred sublicense revenue	7,458		$ 7,622
Alfasigma S.p.A.
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Transaction Price	20,000
Cumulative Sublicense Revenue Recognized	10,948
Deferred Sublicense Revenue	9,052
Less current portion of long-term deferred sublicense revenue	(1,594)
Total long-term deferred sublicense revenue	7,458
License | Alfasigma S.p.A.
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Transaction Price	10,223
Cumulative Sublicense Revenue Recognized	10,223
Deferred Sublicense Revenue	0
Development and Regulatory Services | Alfasigma S.p.A.
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Transaction Price	2,647
Cumulative Sublicense Revenue Recognized	725
Deferred Sublicense Revenue	1,922
Supply of License Product | Alfasigma S.p.A.
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Transaction Price	7,130
Cumulative Sublicense Revenue Recognized	0
Deferred Sublicense Revenue	$ 7,130