Income Taxes - Additional Information (Details) - USD ($)	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Income Taxes [Line Items]
Provision for income taxes	$ 1,600,000	$ 0
Deferred tax assets, valuation allowance	114,349,000	78,065,000
Deferred tax assets, increase (decrease) in valuation allowance	36,300,000	28,100,000
Unrecognized tax benefits that would affect effective tax rate	0
Unrecognized tax benefits	4,636,000	$ 3,345,000	$ 2,560,000
Federal
Income Taxes [Line Items]
Operating loss carryforwards available to offset future taxable income, amount	167,500,000
Federal | Tax Year 2018
Income Taxes [Line Items]
Net operating loss carryforwards	259,100,000
Federal | Tax Year 2018 | Research and Development
Income Taxes [Line Items]
Tax credit carryforwards, amount	$ 7,000,000
Tax credit carryforwards, expiration year	2028
Federal | Tax Year 2018 | Orphan Drug
Income Taxes [Line Items]
Tax credit carryforwards, amount	$ 8,500,000
Tax credit carryforwards, expiration year	2036
Federal | Maximum | Tax Year 2018
Income Taxes [Line Items]
Percentage of utilization net operating loss carryforwards to taxable income	80.00%
Federal | Maximum | Prior to 2018
Income Taxes [Line Items]
Percentage of utilization net operating loss carryforwards to taxable income	100.00%
State
Income Taxes [Line Items]
Operating loss carryforwards available to offset future taxable income, amount	$ 125,800,000
State | Tax Year 2018
Income Taxes [Line Items]
Net operating loss carryforwards	$ 227,600,000
Percentage of utilization net operating loss carryforwards to taxable income	40.00%
Net operating loss carryforwards expiration beginning year	2029
State | Tax Year 2018 | Research and Development
Income Taxes [Line Items]
Tax credit carryforwards, amount	$ 800,000
Tax credit carryforwards, expiration year	2029