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License and Other Agreements - Additional Information (Details) - USD ($)	1 Months Ended			12 Months Ended
	Jun. 30, 2021	Jan. 31, 2020	Nov. 30, 2017	Dec. 31, 2021	Dec. 31, 2020	Mar. 31, 2021
License Agreements [Line Items]
Research and development				$ 102,107,000	$ 72,088,000
Revenue				10,831,000	320,000
Purchase obligation, year 2022 through 2023						$ 14,000,000
Purchase obligation, year 2024						37,000,000
Purchase obligation, year 2025 through 2031						$ 48,000,000
Duke University
License Agreements [Line Items]
Sale of licensed products or services				0
Fees payment				300,000
Nonroyalty payment received				1,000,000
Research and development				0
Wacker
License Agreements [Line Items]
Research and development				400,000	300,000
Viamet Pharmaceuticals Holdings, LLC
License Agreements [Line Items]
Research and development				0	100,000
License agreement upfront payment		$ 100,000
Achievement Of Certain Pre-Revenue Regulatory Milestones \| Alfasigma S.p.A.
License Agreements [Line Items]
Potential milestone payments	$ 35,000,000
Potential milestones payment receivable	35,000,000
Achievement Of Certain Commercial Milestones And Tiered Royalty Payments On Net Sales \| Alfasigma S.p.A.
License Agreements [Line Items]
Potential milestone payments	190,000,000
EMA Approval Of Application For Licensed Product \| Alfasigma S.p.A.
License Agreements [Line Items]
Potential milestones payment receivable	10,000,000
Achievement Of Conditional Regulatory Approval From EMA \| Alfasigma S.p.A.
License Agreements [Line Items]
Potential milestones payment receivable	12,500,000
Achievement Of Unconditional Regulatory Approval From EMA \| Alfasigma S.p.A.
License Agreements [Line Items]
Potential milestones payment receivable	12,500,000
Maximum \| Achievement of Clinical Development and Regulatory Milestones \| Duke University
License Agreements [Line Items]
Potential milestone payments				2,200,000
Maximum \| Commercial Milestones \| Duke University
License Agreements [Line Items]
Potential milestone payments				400,000
Maximum \| Commercial Milestones \| Viamet Pharmaceuticals Holdings, LLC
License Agreements [Line Items]
Potential milestone payments		142,500,000
Maximum \| Payment Upon Achievement of Certain Development and Intellectual Property Milestones \| Viamet Pharmaceuticals Holdings, LLC
License Agreements [Line Items]
Potential milestone payments		$ 5,100,000
Minimum \| Duke University
License Agreements [Line Items]
Aggregate royalties payment				200,000
MedImmune Limited
License Agreements [Line Items]
Milestone payments			$ 3,000,000
MedImmune Limited \| Maximum \| Achievement of Clinical Development and Regulatory Milestones
License Agreements [Line Items]
Potential milestone payments			15,000,000
MedImmune Limited \| Maximum \| Commercial Milestones
License Agreements [Line Items]
Potential milestone payments			$ 50,000,000
Alfasigma S.p.A.
License Agreements [Line Items]
Upfront payment from sublicense agreement	$ 20,000,000
Revenue				$ 10,831,000	$ 0