Deferred Sublicense Revenue (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Cumulative Sublicense Revenue Recognized	$ 10,831	$ 320
Less current portion of long-term deferred sublicense revenue	(1,547)	0
Total long-term deferred sublicense revenue	7,622	0
Alfasigma S.p.A.
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Transaction Price	20,000
Cumulative Sublicense Revenue Recognized	10,831	$ 0
Deferred Sublicense Revenue	9,169
Less current portion of long-term deferred sublicense revenue	(1,547)
Total long-term deferred sublicense revenue	7,622
License | Alfasigma S.p.A.
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Transaction Price	10,223
Cumulative Sublicense Revenue Recognized	10,223
Deferred Sublicense Revenue	0
Development and Regulatory Services | Alfasigma S.p.A.
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Transaction Price	2,647
Cumulative Sublicense Revenue Recognized	608
Deferred Sublicense Revenue	2,039
Supply of License Product | Alfasigma S.p.A.
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Transaction Price	7,130
Cumulative Sublicense Revenue Recognized	0
Deferred Sublicense Revenue	$ 7,130