Deferred Sublicense Revenue (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2021	Sep. 30, 2020	Sep. 30, 2021	Sep. 30, 2020	Dec. 31, 2020
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Cumulative Sublicense Revenue Recognized	$ 335	$ 0	$ 10,673	$ 320
Less current portion of long-term deferred sublicense revenue	(1,414)		(1,414)		$ 0
Total long-term deferred sublicense revenue	7,913		7,913		$ 0
Alfasigma S.p.A.
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Transaction Price			20,000
Cumulative Sublicense Revenue Recognized			10,673
Deferred Sublicense Revenue	9,327		9,327
Less current portion of long-term deferred sublicense revenue	(1,414)		(1,414)
Total long-term deferred sublicense revenue	7,913		7,913
License | Alfasigma S.p.A.
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Transaction Price			10,223
Cumulative Sublicense Revenue Recognized			10,223
Deferred Sublicense Revenue	0		0
Development and Regulatory Services | Alfasigma S.p.A.
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Transaction Price			2,647
Cumulative Sublicense Revenue Recognized			450
Deferred Sublicense Revenue	2,197		2,197
Supply of License Product | Alfasigma S.p.A.
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Transaction Price			7,130
Cumulative Sublicense Revenue Recognized			0
Deferred Sublicense Revenue	$ 7,130		$ 7,130