	UNITED STATES
	SECURITIES AND EXCHANGE COMMISSION
	Washington, D.C. 20549

	SCHEDULE 13D

Under the Securities Exchange Act of 1934
(Amendment No. 2)*

MarkWest Energy Partners, L.P.

(Name of Issuer)

Common Units

(Title of Class of Securities)

570759100

(CUSIP Number)

John M. Fox

MWHC Holding, Inc.

3033 East 1st Avenue

Suite 400

Denver, Colorado 80206

(303) 468-0094

(Name, Address and Telephone Number of Person
Authorized to Receive Notices and Communications)

April 15, 2010

(Date of Event Which Requires Filing of this Statement)

If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box. o

Note: Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See §240.13d-7 for other parties to whom copies are to be sent.

* The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

CUSIP No. 570759100

	1.	Name of Reporting Persons. I.R.S. Identification No(s). of above person(s) (entities only) John M. Fox

	2.	Check the Appropriate Box if a Member of a Group (See Instructions)
		(a)			o
		(b)			o

	3.	SEC Use Only

	4.	Source of Funds (See Instructions) OO

	5.	Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e) o

	6.	Citizenship or Place of Organization United States of America

Number of Shares Beneficially Owned by Each Reporting Person With:			7.	Sole Voting Power 10,948 Common Units

			8.	Shared Voting Power 6,371,313 Common Units

			9.	Sole Dispositive Power 10,948 Common Units

			10.	Shared Dispositive Power 6,371,313 Common Units

	11.	Aggregate Amount Beneficially Owned by Each Reporting Person 6,382,261 Common Units

	12.	Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions) o

	13.	Percent of Class Represented by Amount in Row (11) 9.6%

	14.	Type of Reporting Person (See Instructions) IN

	1.	Name of Reporting Persons. I.R.S. Identification No(s). of above person(s) (entities only) MWHC Holding, Inc.

	2.	Check the Appropriate Box if a Member of a Group (See Instructions)
		(a)			o
		(b)			o

	3.	SEC Use Only

	4.	Source of Funds (See Instructions) OO

	5.	Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e) o

	6.	Citizenship or Place of Organization Colorado

Number of Shares Beneficially Owned by Each Reporting Person With:			7.	Sole Voting Power 5,285,466 Common Units

			8.	Shared Voting Power

			9.	Sole Dispositive Power 5,285,466 Common Units

			10.	Shared Dispositive Power

	11.	Aggregate Amount Beneficially Owned by Each Reporting Person 5,285,466 Common Units

	12.	Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions) o

	13.	Percent of Class Represented by Amount in Row (11) 7.9%

	14.	Type of Reporting Person (See Instructions) CO

INTRODUCTION

This Amendment No. 2 (the “Amendment”) amends and supplements where indicated the Statement on Schedule 13D originally filed on March 3, 2008 by John M. Fox and MWHC Holding, Inc. (“MWHC Holding”) and amended by Amendment No.1 thereto (the “First Amendment”) on August 19, 2009 (as amended by the First Amendment, the “Original Statement”). This Amendment and the Original Statement are collectively referred to herein as the “Schedule 13D.”

Capitalized terms used herein but not defined herein shall have the meanings ascribed to them in the Original Statement. This Amendment amends the Original Statement as specifically set forth herein. Except as set forth below, all previous Items in the Original Statement remain unchanged.

This Amendment is being filed to update the number of Common Units held by the filing parties as a result of the transactions described below.

Since the filing of the First Amendment, Mr. Fox and MWHC Holding have sold Common Units in multiple broker transactions, including those during the last 60 days as reflected herein.

Item 1.	Security and Issuer
This statement on Schedule 13D (this “*Statement”) relates to the Common Units (the “Common Units”) of MarkWest Energy Partners, L.P. (the “Partnership” or “MarkWest*”). The principal executive offices of MarkWest are located at 1515 Arapahoe Street, Tower 2, Suite 700, Denver, Colorado 80202.

Item 2.	Identity and Background
(a) This Statement is being filed by John M. Fox and MWHC Holding, Inc., a Colorado corporation (“*MWHC Holding”). (b)* The address of the principal business office of each of Mr. Fox and MWHC Holding is 3033 East 1st Avenue, Suite 400, Denver, Colorado 80206. (c) Prior to his resignation on January 26, 2010, Mr. Fox had served as a member of the board of directors of MarkWest Energy GP, L.L.C., the general partner of the Partnership (the “*General Partner”), since May 2002. Prior to his resignation, Mr. Fox was the Lead Director of the board of directors of the General Partner and previously served as the board’s chairman from May of 2002 through October of 2008. Mr. Fox had served as Chairman of MarkWest Hydrocarbon, Inc. (“Hydrocarbon”) from its inception in April 1988 until the merger of MWEP, L.L.C., a subsidiary of the Partnership with and into Hydrocarbon (the “Merger”) pursuant to the terms of that Agreement and Plan of Redemption and Merger, dated as of September 5, 2007 (the “Redemption and Merger Agreement”), which was effected on February 21, 2008. Mr. Fox also served as President and Chief Executive Officer of Hydrocarbon since April 1988 and of the General Partner since May 2002 until his retirement as President on November 1, 2003, and his resignation as Chief Executive Officer effective December 31, 2003. MWHC Holding is a Colorado corporation and the principal business of MWHC Holding prior to the Merger was to act as a holding company for 4,482,387 shares of Hydrocarbon common stock. Following the Merger, the principal business of MWHC Holding is to act as a holding company for the Common Units it received in the Merger. The board of directors of MWHC Holding consists of Mr. Fox and his spouse, Marcella F. Fox. Mr. Fox is the only executive officer of MWHC Holding. Mrs. Fox is not currently employed and has not been employed during the past five years. The address for Mrs. Fox is 3033 East 1st Avenue, Suite 400, Denver, Colorado 80206. (d)* During the past five years, neither Mr. Fox, MWHC Holding nor Mrs. Fox has been convicted in a criminal proceeding (excluding traffic violations or similar misdemeanors). (e) During the past five years, neither Mr. Fox, MWHC Holding nor Mrs. Fox was a party to a civil proceeding of a judicial or administrative body of competent jurisdiction as a result of which such person was or is subject to a judgment, decree or final order enjoining future violations of, or prohibiting or mandating activities subject to, federal or state securities laws or finding any violation with respect to such laws. (f) Mr. Fox and Mrs. Fox are citizens of the United States.

Item 4.	Purpose of Transaction
Item 4 of the Schedule 13D is hereby supplemented by adding the following paragraphs: Since the filing of the First Amendment, Mr. Fox and MWHC Holding have sold Common Units in multiple broker transactions, including those during the last 60 days as reflected herein. The sales effected by Mr. Fox and MWHC Holding during 2010 have been pursuant to trading plans adopted under Rule 10b5-1 under the Securities Exchange Act of 1934, as amended. Other than as set forth in this Item 4, neither Mr. Fox nor MWHC Holding has any current plans, proposals or negotiations that relate to or would result in any of the matters referred to in paragraphs (a) through (j) of Item 4 of Schedule 13D.

Item 5.	Interest in Securities of the Issuer
*Mr. Fox* (a) As of the close of business on April 23, 2010, Mr. Fox may be deemed the beneficial owner of 6,382,261 Common Units, representing approximately 9.6% of the outstanding Common Units as reported on the Partnership’s Annual Report on Form 10-K for the year ended December 31, 2009. The foregoing includes 861,042 Common Units held jointly by Mr. Fox and his spouse, 5,285,466 Common Units directly owned by MWHC Holding, 224,805 Common Units directly owned by the Fox Family Foundation, and 0 Common Units directly owned by Bode Blanco. Mr. Fox is the President, Treasurer and a director of the Fox Family Foundation and a member of Bode Blanco. Mr. Fox disclaims beneficial ownership of the Common Units reported herein, except to the extent of any pecuniary interest therein. The MaggieGeorge Foundation for which certain family members of Mr. Fox are directors, holds 155,529 Common Units in the aggregate which are not included in the units for which Mr. Fox may be deemed the beneficial owner. Mr. Fox disclaims beneficial ownership of the units held in the MaggieGeorge Foundation. (b) Mr. Fox has sole voting and investment power with respect to 10,948 Common Units. Mr. Fox has shared voting and investment power with respect to 6,371,313 Common Units, which includes 861,042 Common Units held jointly with his spouse, 5,285,466 Common Units directly owned by MWHC Holding, 224,805 Common Units directly owned by the Fox Family Foundation and 0 Common Units directly owned by Bode Blanco. The address of the principal business office of the Fox Family Foundation and each of its executive officers and directors is 3033 East 1st Avenue, Suite 400, Denver, Colorado 80206. The Fox Family Foundation is a Colorado corporation formed for the purpose of assisting underprivileged parents and their newborn children, the education of underprivileged children and the advancement of women in economic and social distress. Set forth in Schedule I to this Schedule 13D is the name and present principal occupation or employment of each of the Fox Family Foundation’s directors and executive officers. During the past five years, neither the Fox Family Foundation nor any person set forth on Schedule I to this Schedule 13D has been convicted in a criminal proceeding (excluding traffic violations or similar misdemeanors). During the past five years, neither the Fox Family Foundation nor any person set forth on Schedule I to this Schedule 13D was a party to a civil proceeding of a judicial or administrative body of competent jurisdiction as a result of which such person was or is subject to a judgment, decree or final order enjoining future violations of, or prohibiting or mandating activities subject to, federal or state securities laws or finding any violation with respect to such laws. Each of the persons set forth on Schedule I to this Schedule 13D is a United States citizen. The address of the principal business office of the Bode Blanco and Peter Mounsey, the manager of Bode Blanco is 3033 East 1st Avenue, Suite 400, Denver, Colorado 80206. Bode Blanco is a Colorado limited liability company formed for the purpose of holding certain assets of the Fox family. Peter Mounsey is the manager of Bode Blanco, L.L.C. Mr. Mounsey is the manager of Mak-J Energy, an oil and gas company. During the past five years, Mr. Mounsey has not been convicted in a criminal proceeding (excluding traffic violations or similar misdemeanors). During the past five years, Mr. Mounsey has not been a party to a civil proceeding of a judicial or administrative body of competent jurisdiction as a result of which he was or is subject to a judgment, decree or final order enjoining future violations of, or prohibiting or mandating activities subject to, federal or state securities laws or finding any violation with respect to such laws. Mr. Mounsey is a United States citizen.

(c) See Appendix 1 annexed hereto. Other than the broker transactions listed on Appendix 1, during the last 60 days, Mr. Fox has not, individually or through the entities through which Mr. Fox may be deemed the beneficial owner of Common Units, effected any transactions in the Partnership’s Common Units.

(d) Not applicable.

(e) Not applicable.

MWHC Holding

(a)-(b) As of the close of business on April 23, 2010, MWHC Holding is the beneficial owner of 5,285,466 Common Units, representing approximately 7.9% of the outstanding Common Units as reported on the Partnership’s Annual Report on Form 10-K for the year ended December 31, 2009. MWHC Holding has sole voting and investment power with respect to such Common Units.

(c) See Appendix 1 annexed hereto. Other than the broker transactions listed on Appendix 1, during the last 60 days, MWHC Holding has not effected any transactions in the Partnership’s Common Units.

(d) Not applicable.

(e) Not applicable.

Item 7.

Material to be Filed as Exhibits

Exhibit No.		Description

	1	Amended and Restated Class B Membership Interest Contribution Agreement, dated as of October 26, 2007, by and among the Partnership and the sellers named therein (incorporated by reference to Exhibit 10.1 to the Current Report on Form 8-K filed November 1, 2007 by the Partnership).

	2	Amendment No. 4 to Amended and Restated Class B Membership Interest Contribution Agreement, effective February 19, 2008, by and among the Partnership and the sellers named therein.*

	3	Registration Rights Agreement, dated as of February 21, 2008, by and among the Partnership, Mr. Fox and MWHC Holding (incorporated by reference to Exhibit 10.1 to the Current Report on Form 8-K filed February 21, 2008 by the Partnership).

	4	Underwriting Agreement dated as of August 13, 2009 among the Partnership, MarkWest Energy Operating Company, L.L.C., MWHC Holding, Morgan Stanley & Co. Incorporated and UBS Securities, LLC, as representatives of the underwriters (incorporated by reference to Exhibit 1.1 to the Current Report on Form 8-K filed August 14, 2009 by the Partnership).

	5	Form of Lockup Letter Agreement by John M. Fox in connection with the June 2009 Offering (incorporated by reference to Schedule II to the Underwriting Agreement dated as of June 5, 2009 among the Partnership, MarkWest Energy Operating Company, L.L.C. and Morgan Stanley & Co. Incorporated which is filed as Exhibit 1.1 to the Current Report on form 8-K filed June 10, 2009 by the Partnership).

	6	Form of Lockup Letter Agreement by John M. Fox and MWHC Holding in connection with the August 2009 Offering (incorporated by reference to

SCHEDULE I

DIRECTORS AND OFFICERS OF THE FOX FAMILY FOUNDATION

Name	Position with Fox Family Foundation	Principal Occupation or Employment
John M. Fox	Director, President and Treasurer	See Item 2(c)
Marcella F. Fox	Director, Vice President	See Item 2(c)
John M. Fox, Jr.	Director, Secretary	Student
Kelley P. Fox	Director, Assistant Secretary	Owner of Priscilla-Cornell Interior Design
Becca Selvidge Fox	Director, Officer	Not currently employed
Peter Mounsey	Director, Officer	Manager of Mak-J Energy

APPENDIX 1

TRANSACTIONS IN

MARKWEST ENERGY PARTNERS, L.P. COMMON UNITS — PAST 60 DAYS

Trade Date	Selling Party	Common Units Sold	Sales Price		Average Per Unit Price for Sales
03/09/10	Bode Blanco	1,865	$	58,547	$	31.39
04/01/10	Mr. Fox (jointly with spouse)	13,000	$	400,233	$	30.79
04/01/10	MWHC Holding	84,500	$	2,601,254	$	30.78
04/08/10	Mr. Fox (jointly with spouse)	3,000	$	93,302	$	31.10
04/08/10	MWHC Holding	19,500	$	606,625	$	31.11
04/12/10	Mr. Fox (jointly with spouse)	2,000	$	62,710	$	31.36
04/12/10	MWHC Holding	13,000	$	407,613	$	31.35
04/15/10	Mr. Fox (jointly with spouse)	3,000	$	93,855	$	31.29
04/15/10	MWHC Holding	19,500	$	609,994	$	31.28
04/19/10	Mr. Fox (jointly with spouse)	2,000	$	61,894	$	30.95
04/19/10	MWHC Holding	13,000	$	402,125	$	30.93
04/20/10	Mr. Fox (jointly with spouse)	2,000	$	63,022	$	31.51
04/20/10	MWHC Holding	13,000	$	409,807	$	31.52
04/22/10	Mr. Fox (jointly with spouse)	3,000	$	94,044	$	31.35
04/22/10	MWHC Holding	19,500	$	611,418	$	31.35

Exhibit Index

Exhibit No.		Description

	1	Amended and Restated Class B Membership Interest Contribution Agreement, dated as of October 26, 2007, by and among the Partnership and the sellers named therein (incorporated by reference to Exhibit 10.1 to the Current Report on Form 8-K filed November 1, 2007 by the Partnership).

	2	Amendment No. 4 to Amended and Restated Class B Membership Interest Contribution Agreement, effective February 19, 2008, by and among the Partnership and the sellers named therein (incorporated by reference to Exhibit 2 to the Original Statement filed on March 3, 2008).

	3	Registration Rights Agreement, dated as of February 21, 2008, by and among the Partnership, Mr. Fox and MWHC Holding (incorporated by reference to Exhibit 10.1 to the Current Report on Form 8-K filed February 21, 2008 by the Partnership).

	4	Underwriting Agreement dated as of August 13, 2009 among the Partnership, MarkWest Energy Operating Company, L.L.C., MWHC Holding, Morgan Stanley & Co. Incorporated and UBS Securities, LLC, as representatives of the underwriters (incorporated by reference to Exhibit 1.1 to the Current Report on Form 8-K filed August 14, 2009 by the Partnership).

	5	Form of Lockup Letter Agreement by John M. Fox in connection with the June 2009 Offering (incorporated by reference to Schedule II to the Underwriting Agreement dated as of June 5, 2009 among the Partnership, MarkWest Energy Operating Company, L.L.C. and Morgan Stanley & Co. Incorporated which is filed as Exhibit 1.1 to the Current Report on form 8-K filed June 10, 2009 by the Partnership).

	6	Form of Lockup Letter Agreement by John M. Fox and MWHC Holding in connection with the August 2009 Offering (incorporated by reference to Schedule III to the Underwriting Agreement dated as of August 13, 2009 among the Partnership, MarkWest Energy Operating Company, L.L.C., MWHC Holding, Morgan Stanley & Co. Incorporated and UBS Securities, LLC, as representatives of the underwriters which is filed as Exhibit 1.1 to the Current Report on form 8-K filed August 14, 2009 by the Partnership).

	7	Agreement of Joint Filing.


	* Previously filed.

	/s/ John M. Fox
	John M. Fox

	MWHC Holding, Inc.

	By:	/s/ John M. Fox
	Name: John M. Fox
	Title: President

	/s/ John M. Fox
	John Fox

	MWHC Holding, Inc.

	By:	/s/ John M. Fox
	Name: John M. Fox
	Title: President


			Schedule III to the Underwriting Agreement dated as of August 13, 2009 among the Partnership, MarkWest Energy Operating Company, L.L.C., MWHC Holding, Morgan Stanley & Co. Incorporated and UBS Securities, LLC, as representatives of the underwriters which is filed as Exhibit 1.1 to the Current Report on form 8-K filed August 14, 2009 by the Partnership).

	7		Agreement of Joint Filing.


	* Previously filed.