Exhibit 21

SUBSIDIARIES OF THE REGISTRANT

XPO Logistics, Inc. maintains approximately 145 subsidiaries. Set forth below are the names of certain wholly owned or at least 90% owned subsidiaries of XPO Logistics, Inc., as of December 31, 2021, that provide freight transportation services. The names of certain consolidated wholly or at least 90% owned subsidiaries that carry on the same line of business have been omitted.

Name	Country or State of Incorporation
XPO Logistics, Inc.	Delaware
XPO CNW, Inc.	Delaware
XPO Logistics Freight, Inc.	Delaware
XPO Logistics Managed Transportation, LLC	Delaware
XPO Intermodal, Inc.	Tennessee
XPO Global Forwarding, Inc.	Delaware
XPO Last Mile Holding, Inc.	Delaware
XPO Last Mile, Inc.	Georgia
XPO Logistics, LLC	Delaware
XPO Logistics Express, LLC	Delaware
XPO Holdings UK I Limited	United Kingdom
XPO Holdings UK III Limited	United Kingdom
XPO Global Forwarding International	France
XPO Holding Transport Solutions Europe	France