10QSB 1 kyto-10qsb.txt QUARTERLY RPT ENDED DEC 31 2004 UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-QSB (Mark One) [X] QUARTERLY REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended December 31, 2004 ----------------- [ ] TRANSITION REPORT UNDER SECTION 13 OR 15(d) OF THE EXCHANGE ACT For the transition period from _____________ to ____________ Commission file number _______________________________ KYTO BIOPHARMA, INC. -------------------- (Exact name of small business issuer as specified in its charter) FLORIDA 65-1086538 ------- ---------- (State or other jurisdiction of (IRS Employer Identification No.) Incorporation or organization) 41A Avenue Road, Toronto, Ontario, M5R 2G3, Canada -------------------------------------------------- (Address of principal executive offices) (416) 955-0349 -------------- (Issuer's telephone number) ------------------------------------------------------------------------------ (Former name, former address and former fiscal year, if changed since last report) Check whether the issuer (1) filed all reports required to be filed by section 13 or 15(d) of the Exchange Act during the past 12 months (or such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes [X] No [ ] APPLICABLE ONLY TO ISSUERS INVOLVED IN BANKRUPTCY PROCEEDINGS DURING THE PRECEDING FIVE YEARS Check whether the registrant filed all documents and reports required to be filed by Section 12, 13 or 15 (d) of the Exchange Act after the distribution of securities under a plan confirmed by a court. Yes [ ] No [ ] APPLICABLE ONLY TO CORPORATE ISSUERS State the number of shares outstanding of each of the issuer's classes of common equity, as of the latest practicable date: 11,986,149 Common Shares - $0.0001 Par Value - as of December 31, 2004. Transitional Small Business Disclosure Format (Check One) Yes [ ] No [X] KYTO BIOPHARMA, INC. AND SUBSIDIARY (A Development Stage Company) FORM 10-QSB INDEX
PART I. FINANCIAL INFORMATION PAGE NUMBER Item 1. Financial Statements (Unaudited) Unaudited Consolidated Balance Sheet as of December 31, 2004 3 Unaudited Consolidated Statements of Operations for the nine months ended December 31, 2004 and 2003 4 Unaudited Consolidated Statements of Cash Flows for the nine months ended December 31, 2004 and 2003 5 Notes to Unaudited Consolidated Financial Statements 6 Item 2. Management's Discussion and Analysis of Financial Condition and Results of Operations 8 Item 3. Controls and Procedures 9 PART II. OTHER INFORMATION Item 1. Legal Proceedings 10 Item 2. Changes in Securities 10 Item 3. Defaults Upon Senior Securities 10 Item 4. Submission of Matters to a Vote of Security Holders 10 Item 5. Other Information 10 Item 6. Exhibits and Reports on Form 8-K 10 SIGNATURES 12 CERTIFICATIONS 13
2 PART I- FINANCIAL INFORMATION ITEM 1. FINANCIAL STATEMENTS KYTO BIOPHARMA, INC. AND SUBSIDIARY (A Development Stage Company) UNAUDITED CONSOLIDATED BALANCE SHEET DECEMBER 31, 2004 ASSETS ------ CURRENT ASSETS Cash $ 9,504 Other receivables 8,411 ------------ TOTAL CURRENT ASSETS 17,915 ------------ EQUIPMENT, NET 868 ------------ TOTAL ASSETS $ 18,783 ============ LIABILITIES AND STOCKHOLDERS' DEFICIT ------------------------------------- CURRENT LIABILITIES Accounts payable $ 33,563 Accounts payable - officer 13,352 Accounts payable - related party 2,225 Accrued interest payable - related party 11,153 Loans payable - related parties 4,645 ------------ TOTAL CURRENT LIABILITIES 64,938 ------------ LONG TERM LIABILITIES Note Payable, related party 100,000 ------------ TOTAL LIABILITIES 164,938 ------------ REDEEMABLE COMMON STOCK PURSUANT TO PUT OPTION 173,058 shares issued and outstanding, (Redemption value, $173,058) 173,058 ------------ Commitments (Note 3) STOCKHOLDERS' DEFICIT Preferred stock, $1.00 par value, 1,000,000 shares authorized, none issued and outstanding -- Common stock, $0.0001 par value, 25,000,000 shares authorized, 7,268,922 issued and outstanding 1,181 Additional paid-in capital 14,759,735 Deficit accumulated during development stage (6,571,172) Accumulated other comprehensive loss (221,444) ------------ 7,968,300 Less: Subscription Receivable (100,013) Less: Deferred consulting fees (8,187,500) ------------ TOTAL STOCKHOLDERS' DEFICIT (319,213) ------------ TOTAL LIABILITIES AND STOCKHOLDERS' DEFICIT $ 18,783 ============ See Accompanying Notes to Unaudited Consolidated Financial Statements 3 KYTO BIOPHARMA, INC. AND SUBSIDIARY (A Development Stage Company) UNAUDITED CONSOLIDATED STATEMENTS OF OPERATIONS Kyto Biopharma, Inc. and Subsidiary (A Development Stage Company) Consolidated Statements of Operations (Unaudited)
For the period from Three Months Ended Nine Months Ended March 5, 1999 December 31, December 31 (Inception) to 2004 2003 2004 2003 December 31, 2004 ---------- ------------ ---------- ---------- ----------------- Operating Expenses Compensation $ 562,500 $ - $ 562,500 $ - $ 2,151,353 Depreciation and amortization 270 251 765 968 813,313 Consulting 14,783 11,400 37,283 32,973 1,025,027 Bad Debt -- -- -- -- 12,819 Director fees -- -- -- -- 64,100 Financing fees -- -- -- -- 28,781 Professional fees 1,521 8,594 15,051 21,133 72,358 General and administrative 13,281 15,603 41,795 42,274 351,440 Research and development 12,207 5,962 18,729 21,127 1,036,043 Settlement loss 159,986 -- 159,986 -- 159,986 Impairment loss -- -- -- -- 1,191,846 ---------- ---------- ---------- ---------- ---------- Total Operating Expenses 764,548 41,810 836,109 118,475 6,907,066 ---------- ---------- ---------- ---------- ---------- Loss from Operations (764,548) (41,810) (836,109) (118,475) (6,907,066) ---------- ---------- ---------- ---------- ---------- Other Income (Expenses) Interest income -- -- 31 58 4,832 Interest expense (1,575) (1,301) (4,462) (3,352) (13,811) Gain on debt forgiveness -- -- 9,124 -- 68,778 Loss on settlement of accounts payable -- -- -- -- (16,296) Loss on disposal of equipment -- -- -- -- (567) Foreign currency transaction gain (loss) 50,819 41,774 90,801 127,752 292,958 ---------- ---------- ---------- ---------- ---------- Total Other Income (Expense), net 49,244 40,473 95,494 124,458 335,894 ---------- ---------- ---------- ---------- ---------- Net Income (Loss) $ (715,304) $ (1,337) $ (740,615) $ 5,983 $(6,571,172) ========== ========== ========== ========== ========== Comprehensive Income (Loss) Foreign currency translation gain (loss) (50,974) (41,742) (91,455) (127,479) (221,444) ---------- ---------- ---------- ---------- ---------- Total Comprehensive Loss $ (766,278) $ (43,079) $ (832,070) $ (121,496) $(6,792,616) ========== ========== ========== ========== ========== Net Loss Per Share - Basic and Diluted $ (0.08) $ (0.00) $ (0.10) $ 0.00 $ (1.42) ========== ========== ========== ========== ========== Weighted average number of shares outstanding during the year - basic and diluted 9,077,367 6,359,758 7,268,922 6,359,758 4,635,630 ========== ========== ========== ========== ==========
See Accompanying Notes to Unaudited Consolidated Financial Statements 4 KYTO BIOPHARMA, INC. AND SUBSIDIARY (A Development Stage Company) UNAUDITED CONSOLIDATED STATEMENT OF CASH FLOWS
For the period from March 5, 1999 Nine Months Ended December 31 (Inception) to 2004 2003 December 31, 2004 ------------- ------------ ------------------- CASH FLOWS FROM OPERATING ACTIVITIES: Net Income (loss) $ (740,615) $ 5,983 $ (6,571,172) Adjustment to reconcile net income (loss) to net cash used in operating activities: Depreciation and amortization 684 642 813,232 Stock based compensation 562,500 -- 2,040,393 Stock based consulting expense -- -- 854,345 Stock based director fees -- -- 64,100 Stock based rent and administrative fees 199,998 30,000 239,985 Common stock warrants issued as financing fee -- -- 3,786 Loss on disposal of equipment -- -- 567 Impairment loss -- -- 1,191,846 Gain on settlement of accounts payable (9,124) -- (68,778) Loss on settlement of accounts payable (14) -- 16,282 Amortization of stock based financing fee -- -- 24,997 Changes in operating assets and liabilities: (Increase) decrease in: Other receivables (2,755) 3,291 (8,411) Prepaids and other assets 1,325 -- -- Increase (decrease) in: Accounts payable and accrued expenses (100,673) 16,159 475,833 Accounts payable-Related Parties 2,225 10,385 ------------ ------------- ----------- NET CASH PROVIDED BY (USED IN) OPERATING ACTIVITIES (86,449) 56,075 (912,610) ------------ ------------- ----------- CASH FLOWS FROM INVESTING ACTIVITIES: Purchase of property and equipment -- -- (4,463) ------------ ------------- ----------- NET CASH USED IN INVESTING ACTIVITIES -- -- (4,463) ------------ ------------- ----------- CASH FLOWS FROM FINANCING ACTIVITIES: Proceeds from common stock issuance, net of offering cost 150,000 -- 858,235 Loan proceeds from related parties, net 35,000 75,000 318,708 Repayment of loan to related parties -- -- (26,792) ------------ ------------- ----------- NET CASH PROVIDED BY FINANCING ACTIVITIES 185,000 75,000 1,150,151 ------------ ------------- ----------- Effect of Exchange Rate on Cash (91,455) (127,479) (223,574) Net Increase in Cash and Cash Equivalents 7,096 3,596 9,504 Cash and Cash Equivalents at Beginning of Period 2,408 5,430 -- ------------ ------------- ----------- CASH AND CASH EQUIVALENTS AT END OF PERIOD $ 9,504 $ 9,026 $ 9,504 ============ ============= =========== Supplemental Disclosure of Cash Flow Information: Cash paid for: Interest $ -- $ -- $ -- ============ ============= =========== Taxes $ -- $ -- $ -- ============ ============= =========== Supplemental Disclosure of Non-Cash Investing and Financing Activities: Conversion of Debt to Equity $ 160,000 $ -- $ 160,000 ============ ============= =========== Stock issued for expenses $ 199,999 $ -- $ 199,999 ============ ============= =========== Stock issued for consulting $ 6,750,000 $ -- $ 6,750,000 ============ ============= ===========
See Accompanying Notes to Unaudited Consolidated Financial Statements 5 KYTO BIOPHARMA, INC. AND SUBSIDIARY (A Development Stage Company) NOTES TO UNAUDITED CONSOLIDATED FINANCIAL STATEMENTS DECEMBER 31, 2004 NOTE 1 BASIS OF PRESENTATION ------------------------------ The accompanying unaudited consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States of America and the rules and regulations of the United States Securities and Exchange Commission for interim consolidated financial information. Accordingly, they do not include all the information and footnotes necessary for a comprehensive presentation of consolidated financial position and results of operations. It is management's opinion, however, that all material adjustments (consisting of normal recurring adjustments) have been made, which are necessary for a fair consolidated financial statement presentation. The results for the interim period are not necessarily indicative of the results to be expected for the year. Activities during the development stage include acquisition of financing and intellectual properties and research and development activities conducted by others under contracts. For further information, refer to the audited consolidated financial statements and footnotes of the Company for the year ending March 31, 2004 included in the Company's Form 10-KSB. NOTE 2 ACCOUNTS PAYABLE AND LOANS PAYABLE, RELATED PARTIES ------------------------------------------------------------ The Company leases office space and administrative services from a principal stockholder related party. Expenses for the three and nine months ended December 31, 2004 were $10,000 and $30,000 and accrued liabilities at December 31, 2004 was $0.00. Accounts payable-related party of $13,352 and $2,225 are payables to an officer and a director, respectively for expense reimbursement due. In November 2002, the Company received working capital funds from a principal stockholder totaling $50,000 as part of a $100,000 agreement to provide debt financing. During the year ended March 31, 2004, the Company received the remaining $50,000 portion of the debt financing transaction plus an additional $25,000. All activity with this principal stockholder represents a 100% concentration of all debt financing for the nine months ended December 31, 2004. All loans are non-interest bearing, unsecured and due on demand. In the first quarter of fiscal 2004, an additional $35,000 loan was received from the same principal stockholder. The total loans payable to this principal stockholder related party was $160,000 at September 30, 2004. In October 2004, the $160,000 was exchanged for 320,000 common shares (see Note 6). NOTE 3 COMMITMENTS -------------------- In December 2004, the Company signed an Extension Modification of Research Collaboration Agreement with the Research Foundation of State University of New York (RFSUNNY) regarding the reseach and development of the use of monoclonal antibodies to block the vitamin B12 uptake by cancer cells for funding consideration of $35,000 to be appropriated for the initial 6 months of the conduct of the research plan from January 1, 2005 through June 30, 2005. The Company shall amend patent No. 5,688,504 to legally establish joint ownership with RFSUNY. The $35,000 was paid in January 2005. NOTE 4 STOCKHOLDERS' DEFICIENCY --------------------------------- (A) REDEEMABLE COMMON STOCK PURSUANT TO PUT OPTION In November 2002 and February 2003, the Company issued an aggregate 273,058 shares of its common stock having a fair value of $273,058 to settle certain accounts payable under a debt settlement agreement ("agreement") with three unrelated parties. Of the total stock issued in connection with the agreement, two of these parties received an aggregate 173,058 shares of common stock. In addition, these two creditors 6 received a written put option for the aggregate 173,058 shares of common stock previously issued. Specifically, three years from the date of the initial settlement, the put option holders have a thirty-day period in which to notify the Company of their intent to put the options back to the Company at a redemption price of $1.00 per share. The Company will then have 90 days from the notification date to make the required payment. The redemption value of these shares of common stock at September 30, 2004 is $173,058. In accordance with the provisions of EITF No.00-19, since the contract requires a net cash settlement (transfer of assets to settle obligation), the put options are classified preceding stockholders' deficiency as temporary equity. The provisions of SFAS No. 150 were not effective for these transactions since the effective date for SFAS No. 150 was May 31, 2003, with no retroactive accounting treatment allowed. (B) EXPIRED COMMON STOCK OPTION On June 1, 2003, 250,000 stock options having an exercise price of $1.00 per share expired without being exercised. (C) COMMON STOCK In October 2004, the Company entered into a non-brokered private placement of 500,000 shares at a price of $0.50 per share for proceeds of $250,000 with a finance company controlled by a director of the Company. In October 2004, the Company converted a related party loans payable of $160,000 into 320,000 shares of common stock at $0.50 per share. The debt was due to a finance company controlled by a director of the Company and was included in Loans Payable-related party in the accompanying balance sheet. There was no gain or loss on this transaction as it was a related party transaction. In November 2004, the Company entered into a services agreement for two years to generate and increase customer interest in the Company's products and technologies and explore merger/acquisition possibilities. The Company issued 4,500,000 shares of common stock. The stock was valued at the quoted trading price of $1.50 on the grant date resulting in a total value of $6,750,000 to be recognized over the service period of November 1, 2004 through October 31, 2006. A consulting expense of $562,500 was recorded as of December 31, 2004. In December 2004, the Company issued 133,333 shares valued at $1.50 per share based on the quoted trade price in payment of various expenses totaling $40,000 owed to a finance company controlled by a director of the Company. The Company recorded a settlement loss of $159,986. A subscription receivable of $13.00 was recorded as of December 31, 2004. NOTE 5 GAIN ON DEBT FORGIVENESS ------------------------------- The Company recorded a gain on debt forgiveness of $9,124 relating to a vendor invoice. NOTE 6 GOING CONCERN -------------------- As reflected in the accompanying consolidated financial statements, the Company has a working capital deficiency of $47,023, deficit accumulated during development stage of $6,571,172 and a stockholders' deficiency of $319,213 at December 31, 2004. The ability of the Company to continue as a going concern is dependent on the Company's ability to further implement its business plan, raise capital, and generate revenues. The consolidated financial statements do not include any adjustments that might be necessary if the Company is unable to continue as a going concern. The Company is currently a development stage company and its continued existence is dependent upon the Company's ability to resolve its liquidity problems, principally by obtaining additional debt financing and/or equity capital. During the three months ended June 30, 2004, the Company received $35,000 in related party debt financing (See notes 2 and 4). In October 2004, the Company closed on a non-brokered private placement of 500,000 shares at a price of $0.50 per share for proceeds of $250,000 of which $100,000 is due in January 2005 and has also converted a debt of $160,000 into 320,000 shares of common stock (See Note 7). The Company has yet to generate an internal cash flow, and until the sales of its product begins, the Company is very dependent upon debt and equity funding. The Company must successfully complete its research and development resulting in a saleable product. However, there is no assurance that once the development of the product is completed 7 and finally gains Federal Drug and Administration clearance, that the Company will achieve a profitable level of operations. NOTE 7 SUBSEQUENT EVENT ----------------------- In January 2005, the Company received the remaining $100,000 from a private placement announced in October 2005. In February 2005, the Company received the $13 subscription receivable from the issuance of 133,333 shares in December 2004. ITEM 2. MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS PLAN OF OPERATION The following discussion should be read in conjunction with the financial statements and related notes which are included in this quarterly report. Statements made below which are not historical facts are forward-looking statements. Forward-looking statements involve a number of risks and uncertainties including, but not limited to, general economic conditions and our ability to develop our products. For further information regarding our business, competition and risk factors, refer to the Company's Form 10-KSB filed with the U.S. Securities Exchange Commission for the year ending March 31, 2004. Kyto is in the development stage of its operations and was formed in March 1999 to acquire and develop early-stage compounds which may have potential use as therapeutic agents for the treatment of cancer and diseases of the immune system. The Company intends to build itself into a biopharmaceutical company that develops receptor-mediated technologies to control the uptake of vitamin B12 by non-controlled proliferative cells. Vitamin B12 regulates one of two major cellular pathways for the production of folates, the cell's primary source of carbon and the progenitor for the synthesis of DNA. Kyto is currently engaged in the development of a portfolio of potential targeted biologic treatments based on: i) the delivery of cytotoxic drugs to cancer cells using the vitamin B12 as a Trojan Horse, ii) the therapeutic effect of vitamin B12 depletion by receptor modulators, and iii) the use of monoclonal antibodies to block the vitamin B12 uptake by cancer cells. Kyto's portfolio consists of molecules at the research and development stage which may ultimately prove useful in the treatment of certain types of cancer and inflammatory diseases. Kyto believes that there are several human therapeutics applications for its drug candidates. Specifically, a number of properties of the Company's drug delivery and vitamin B12 depletion technologies suggest a potential role for its drug candidates in the therapy of solid tumors such as colorectal and breast cancer in addition to treatment of leukemias. The Company had not been profitable and had no revenues from operations since its inception in March 1999. As reflected in the accompanying unaudited consolidated financial statements, the Company has a working capital deficiency of $47,023, deficit accumulated during development stage of $6,571,172 and a stockholders' deficiency of $319,213 at December 31, 2004. The ability of the Company to continue as a going concern is dependent on the Company's ability to further implement its business plan, raise capital, and generate revenues. The consolidated financial statements do not include any adjustments that might be necessary if the Company is unable to continue as a going concern. The Company is currently a development stage company and its continued existence is dependent upon the Company's ability to resolve its liquidity problems, principally by obtaining additional debt financing and/or equity capital. The Company has yet to generate an internal cash flow, and until the sales of its product begins, the Company is very dependent upon debt and equity funding. The Company must successfully complete its research and development resulting in a saleable product. However, there is no assurance that once the development of the product is completed and finally gains Federal Drug and Administration clearance, that the Company will achieve a profitable level of operations. 8 The Company has, as of the end of December 31, 2004, $164,938 in total liabilities. We reduced our research activities and the Company estimates that it will require approximately $120,000 to meet its operating costs for this fiscal year, excluding research and development costs. The Company is seeking up to five million dollars ($5,000,000) in research and development funds. In October 2004, the Company closed on a non-brokered private placement of 500,000 shares of common stock at a price of $0.50 per share for proceeds of $250,000 with a related party controlled by a director of the Company. The Company has also converted a debt of $160,000 into 320,000 shares of common stock at the same price. The proceeds from the private placement from that same related party will be used by the Company to develop its portfolio of potential targeted biologic treatments and applied to its working capital. In December 2004, the Company signed an Extension Modification of Research Collaboration Agreement with the Research Foundation of State University of New York (RFSUNNY) regarding the reseach and development of the use of monoclonal antibodies to block the vitamin B12 uptake by cancer cells for funding consideration of $35,000 to be appropriated for the initial 6 months of the conduct of the research plan from January 1, 2005 through June 30, 2005. The Company shall amend patent No. 5,688,504 to legally establish joint ownership with RFSUNY. The $35,000 was paid in January 2005. To meet the projected cash requirements as stated above, the Company intends to obtain cash loans from one or more of its stockholders, several of whom have expressed a desire to provide operating loan funds for the Company. Additionally, the Company intends to seek alliances with other pharmaceutical and biotechnology companies for product co-development. Management is also looking to merger opportunities or to acquire companies and products to raise capital. The Company's plan of operation for the next twelve months is to continue to focus its efforts on finding new sources of capital. Management expects the Company to incur additional operating losses over the next several years as research and development efforts, preclinical and clinical testing activities and manufacturing scale-up efforts expand. To date, we have not had any material product sales and do not anticipate receiving any revenue from the sale of products in the upcoming year. Our sources of working capital have been equity financings and interest earned on investments. The Company operates in a rapidly changing environment that involves a number of factors, some of which are beyond management's control, such as financial market trends and investors' appetite for new financings. It should also be emphasized that, should the Company not be successful in completing its own financing (either by debt or by the issuance of securities from treasury), the Company may be unable to continue to operate as a going concern. ITEM 3. CONTROLS AND PROCEDURES (a) Evaluation of Disclosure Controls and Procedures: An evaluation of the registrant's disclosure controls and procedures (as defined in Section 13(a)-14(c) of the Securities Exchange Act of 1934 (the "Act")) was carried out under the supervision and with the participation of the Registrant's President and Chief Executive Officer within the 90-day period preceding the filing date of this quarterly report. The registrant's President and Chief Executive Officer concluded that the registrant's disclosure controls and procedures as currently in effect are effective in ensuring that the information required to be disclosed by the registrant in the reports it files or submits under the Act is (i) accumulated and communicated to the registrant's management in a timely manner, and (ii) recorded, processed, summarized and reported within the time periods specified in the SEC's rules and forms. (b) Changes in Internal Controls: In the Quarter ended December 31, 2004, the registrant did not make any significant changes in, nor take any corrective actions regarding, its internal controls or other factors that could significantly affect these controls. 9 PART II. OTHER INFORMATION ITEM 1. LEGAL PROCEEDINGS None ITEM 2. CHANGES IN SECURITIES None ITEM 3. DEFAULTS UPON SENIOR SECURITIES None ITEM 4. SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS None ITEM 5. OTHER INFORMATION None. ITEM 6. EXHIBITS AND REPORTS ON FORM 8-K Index to Exhibits on page 11. 10 INDEX TO EXHIBITS EXHIBIT NUMBER DESCRIPTION -------------- ----------- 3(i)(a) Articles of Incorporation of Kyto Biopharma, Inc.* 3(i)(b) Articles of Amendment changing name to Kyto Biopharma, Inc.* 3(ii) Bylaws of Kyto Biopharma, Inc.* 31.1 Section 302 Certification** 32.1 Certification pursuant to 18 U.S.C. Section 1350 as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 ** *Filed as Exhibit to Company's Form 10-SB on September 12th, 2003, with the Securities and Exchange Commission **Filed as Exhibit with this Form 10-QSB, page 12. 11 SIGNATURES In accordance with the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized. Kyto Biopharma, Inc. -------------------- (Registrant) Date February 15, 2005 /s/ Jean-Luc Berger, Director ----------------- ----------------------------- (Signature) Jean-Luc Berger President and Chief Executive Officer 12