UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549





                                    FORM 8-K
                                 Current Report


                       Pursuant to Section 13 or 15(d) of
                       The Securities Exchange Act of 1934



                Date of Report (date of earliest event reported):

                                 April 25, 2007



                     MEDICAL STAFFING NETWORK HOLDINGS, INC.
             (Exact name of registrant as specified in its charter)



          Delaware                   001-31299                 65-0865171
      ----------------        -------------------------      --------------
(State or other jurisdiction  (Commission File Number)        (IRS Employer
     of incorporation)                                      Identification No.)

                901 Yamato Road, Suite 110, Boca Raton, FL 33431
                ------------------------------------------------
                    (Address of principal executive offices)

        Registrant's telephone number, including area code: 561-322-1300
                                                            ------------

Check the appropriate box below if the Form 8-K filing is intended to
simultaneously satisfy the filing obligation of the registrant under any of the
following provisions:

     |_| Written communications pursuant to Rule 425 under the Securities Act
(17 CFR 230.425)

     |_| Soliciting material pursuant to Rule 14a-12 under the Exchange Act
(17 CFR 240.14a-12)

     |_| Pre-commencement communications pursuant to Rule 14d-2(b) under the
Exchange Act (17 CFR 240.14d-2(b))

     |_| Pre-commencement communications pursuant to Rule 13e-4(c) under the
Exchange Act (17 CFR 240.13e-4(c))




Item 7.01.  Regulation FD Disclosure

         The registrant is attaching a copy of a press release dated April 25,
2007, as Exhibit 99.1.

Item 9.01.  Financial Statements and Exhibits

            (d) Exhibits:

                99.1   Press Release of Medical Staffing Network Holdings, Inc.,
                       dated April 25, 2007.

Limitation on Incorporation by Reference

     In accordance with General Instruction B.2 of Form 8-K, the information in
this report (including the exhibit) is furnished pursuant to Item 7.01 and shall
not be deemed to be "filed" for the purposes of Section 18 of the Securities
Exchange Act of 1934, as amended, or otherwise subject to liabilities of that
Section, unless we specifically incorporate it by reference in a document filed
under the Securities Act of 1933 or the Securities Exchange Act of 1934. The
filing of this Current Report on Form 8-K is not an admission as to the
materiality of any information in this report that is required to be disclosed
solely by Regulation FD.




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                                    SIGNATURE

     Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.



Date:  April 25, 2007                 MEDICAL STAFFING NETWORK HOLDINGS, INC.



                                      By: /s/ Kevin S. Little
                                         --------------------------------
                                          Kevin S. Little
                                          President and Chief Financial Officer









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                                  EXHIBIT INDEX



Exhibit No.      Description

99.1             Press Release of Medical Staffing Network Holdings, Inc., dated
                 April 25, 2007.










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