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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2022
Mar. 31, 2021
Cash flows from operating activities:    
Net loss $ (8,300) $ (10,217)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 8 47
Amortization of right-of-use assets 33 57
Foreign currency loss 13 57
Amortization of debt issuance costs 153 140
Amortization on premium to short-term investments 267 161
Stock-based compensation 574 946
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets 1,638 879
Non-current assets (332) (863)
Accounts payable and accrued expenses and other current liabilities (2,479) (781)
Long-term liabilities (23)
Net cash used in operating activities (8,425) (9,597)
Cash flows from investing activities:    
Purchase of available-for-sale securities, net (16,004) (94,319)
Maturities of available-for-sale securities 58,393 16,580
Sale of available-for-sale securities, net 11,276  
Net cash provided by (used in) investing activities 53,665 (77,739)
Cash flows from financing activities:    
Repurchase of outstanding pre-funded warrants   (3,909)
Issuance of common stock and pre-funded warrants in public offering, net of offering costs   121,827
Proceeds from exercise of stock options   2
Issuance of common stock upon exercise of warrants, net   2,546
Repurchase of shares for minimum tax withholdings (1)  
Net cash (used in) provided by financing activities (1) 120,466
Effect of exchange rate changes on cash and cash equivalents (24) (28)
Increase in cash and cash equivalents 45,215 33,102
Cash and cash equivalents beginning of period 34,012 22,880
Cash and cash equivalents end of period 79,227 55,982
Supplemental disclosure of cash flow information:    
Cash paid for interest $ 484 $ 484