Exhibit 32.1

CERTIFICATION PURSUANT TO 18 U.S.C. SEC. 1350

    In connection with the filing by AlerisLife Inc. (the “Company”) of the Quarterly Report on Form 10-Q for the quarter ended September 30, 2022 (the “Report”), each of the undersigned hereby certifies, to the best of his or her knowledge:

1.The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

2.The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

	/s/ Jeffrey C. Leer
	Jeffrey C. Leer
	President and Chief Executive Officer
	/s/ Heather C. Pereira
	Heather C. Pereira
	Senior Vice President, Chief Financial Officer and Treasurer
Date: November 2, 2022