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Share-based Compensation (Tables)
 3 Months Ended
Mar. 31, 2022
Share-based Payment Arrangement, Noncash Expense [Abstract]  
Schedule of share-based compensation expense
Total share-based compensation expense related to share-based awards was comprised of the following (in thousands):
Three Months Ended
 March 31,
 20222021
Research and development$2,017 $1,648 
Selling, general and administrative2,725 3,275 
Share-based compensation expense$4,742 $4,923 
Schedule of share-based compensation expense by type
Share-based compensation expense by type of share-based award (in thousands):
Three Months Ended
 March 31,
 20222021
Stock options$2,620 $2,482 
RSAs, RSUs, PSUs and ESPP2,122 2,441 
$4,742 $4,923 
Schedule of assumptions used in Black-Scholes model The assumptions used in the Black-Scholes model were as follows:
Three Months Ended
 March 31,
 20222021
Expected volatility
41.14-41.23%
45.75-46.45%
Average expected term (in years)4.74.7
Risk-free interest rate
1.37-1.90%
0.36-0.71%
Expected dividend yield— — 
Schedule of unrecognized estimated compensation cost by type
Total unrecognized estimated compensation cost by type of award and the weighted-average remaining requisite service period over which such expense is expected to be recognized (in thousands, unless otherwise noted):
March 31, 2022
 Unrecognized
Expense		Remaining
Weighted-Average
Recognition Period
(years)
Stock options$31,638 2.91
RSUs$26,620 2.83
PSUs$6,092 2.66
ESPP$75 0.21